Cadmium induced cardiac toxicology in developing Japanese quail (Coturnix japonica): Histopathological damages, oxidative stress and myocardial muscle fiber formation disorder

Li, Xuan; Zheng, Ying; Zhang, Gaixia; Wang, Rui; Jiang, Jun; Zhao, Hongfeng

doi:10.1016/j.cbpc.2021.109168

Cited by 10 publications

(2 citation statements)

References 55 publications

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“…Cd-induced nephrotoxicity is closely related to oxidative stress, resulting in the peroxidation of biological macromolecules, such as proteins, lipids and DNA [ 14 ]. Many trace elements are involved in regulating the balance of the oxidative-antioxidant system as key cofactors of antioxidant enzymes or as natural antioxidants; however, Cd can replace or reduce the absorption of trace elements involved in antioxidants [ 42 , 43 ]. Our study showed that Cd caused an increase in MDA content, but a decrease in GSH content, and a decrease in T-AOC, T-SOD and CAT activities in quail kidneys compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Honokiol Antagonizes Cadmium-Induced Nephrotoxicity in Quail by Alleviating Autophagy Dysfunction, Apoptosis and Mitochondrial UPR Inhibition with Its Antioxidant Properties

Zhang

Dong

et al. 2022

Life

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Japanese quail is a highly economically valuable bird due to its commercial production for meat and eggs. Although studies have reported Cadmium (Cd) is a ubiquitous heavy metal that can cause injury to various organs, the molecular mechanisms of Cd on quail kidney injury remain largely unknown. It has been reported that Honokiol (HKL), a highly functional antioxidant, can protect cells against oxidative stress effectively. This study was conducted to investigate the effects of Cd on quail kidneys injury and the protective effect of HKL on Cd-induced nephrotoxicity. A total of 40 Japanese quails were randomly divided into four groups: the control group, Cd treatment group, Co-treatment group and HKL treatment group. The results showed that Cd resulted in significant changes in growth performance, kidney histopathology and kidney biochemical status, antioxidant enzymes and oxidative stress parameters, and ultrastructure of renal tubular epithelial cells, compared with controls. Cd increased the expression of autophagy-related and apoptosis-related genes, but decreased expression of lysosomal function-related and UPRmt-related genes. The co-treatment group ameliorated Cd-induced nephrotoxicity by alleviating oxidative stress, inhibiting apoptosis, repairing autophagy dysfunction and UPRmt disorder. In conclusion, dietary supplementation of HKL showed beneficial effects on Japanese quail kidney injury caused by Cd.

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Section: Discussionmentioning

confidence: 99%

Honokiol Antagonizes Cadmium-Induced Nephrotoxicity in Quail by Alleviating Autophagy Dysfunction, Apoptosis and Mitochondrial UPR Inhibition with Its Antioxidant Properties

Zhang

Dong

et al. 2022

Life

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“…Previously published reports indicate that Cd intoxication can lead to cardiac injury as well as adverse effects on hypertension. The accumulation and toxicity levels of Cd are determined by the dose and time of exposure [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective Effect of Eugenol Against Cd-Induced Inflammation, Oxidative Stress, and Dyslipidemia in Male Rats: An In Vivo and Molecular Docking Study

Kumar,

Sharma

2024

Biol Trace Elem Res

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BackgroundCadmium, a highly toxic heavy metal, can cause severe damage to several vital organs including the kidney, liver and brain. Many of the natural compounds found in aromatic plants have bene cial pharmacological properties, Eugenol, is one such compound reported to have anti-in ammatory and antioxidant properties. This study aimed to examine the potential of eugenol in alleviating cardiac in ammation, oxidative stress and dyslipidemia caused by cadmium exposure. MethodsMale albino rats were randomized into four groups with six animals in each group, to examine the role of eugenol in reversing cadmium toxicity. All groups received oral gavage treatment for 21 days. Afterwards, heart tissues were collected from the rats. Assessment of the cardiac antioxidant status was performed by analyzing the enzymatic activities of Catalase, SOD, GST and GPx. Levels of lipid peroxidation, reduced glutathione, protein carbonyl oxidation, and thiol levels were determined in heart tissue. To evaluate cardiac damage, marker enzymes such as LDH and CK-MB were measured. Cadmium-induced cardiac in ammation was assessed by measuring NO, TNF-α and IL-6 levels. Docking and molecular dynamics studies were conducted using autodock and GLIDE. ResultsCadmium administration markedly enhanced the activities of LDH and CK-MB, prominent cardiac markers. Furthermore, cadmium treatment also demonstrated a signi cant decrease in the reduced glutathione levels and antioxidant enzyme activities. Signi cant elevation of the in ammatory markers was also observed in the cadmium-treated group. Eugenol treatment effectively ameliorates cadmiuminduced biochemical changes. ConclusionThis study highlights eugenol's strong anti-in ammatory and antioxidant properties. Co-supplementation of eugenol with cadmium demonstrated its protective potential against cadmium-induced cardiotoxicity.Eugenol was able to restore the cellular redox system of cadmium-treated rats to normal control levels.

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The Effects of Chronic Lead Exposure on Testicular Development of Japanese Quail (Coturnix japonica): Histopathological Damages, Oxidative Stress, Steroidogenesis Disturbance, and Hypothalamus-Pituitary-Testis Axis Disruption

Zheng

Jing²,

Fei³

et al. 2022

Biol Trace Elem Res

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Cadmium induced cardiac toxicology in developing Japanese quail (Coturnix japonica): Histopathological damages, oxidative stress and myocardial muscle fiber formation disorder

Cited by 10 publications

References 55 publications

Honokiol Antagonizes Cadmium-Induced Nephrotoxicity in Quail by Alleviating Autophagy Dysfunction, Apoptosis and Mitochondrial UPR Inhibition with Its Antioxidant Properties

Honokiol Antagonizes Cadmium-Induced Nephrotoxicity in Quail by Alleviating Autophagy Dysfunction, Apoptosis and Mitochondrial UPR Inhibition with Its Antioxidant Properties

Cardioprotective Effect of Eugenol Against Cd-Induced Inflammation, Oxidative Stress, and Dyslipidemia in Male Rats: An In Vivo and Molecular Docking Study

The Effects of Chronic Lead Exposure on Testicular Development of Japanese Quail (Coturnix japonica): Histopathological Damages, Oxidative Stress, Steroidogenesis Disturbance, and Hypothalamus-Pituitary-Testis Axis Disruption

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