Cadmium-Induced Oxidative Stress in the Bivalve Mollusk Modiolus modiolus

Abstract

Cadmium-induced oxidative stress in the bivalve Modiolus modiolus is studied from the standpoint of the universality of the mechanism of free-radical oxidation. The kinetics of cadmium accumulation by the bivalve was revealed in a laboratory experiment. The gills accumulated higher Cd levels than the digestive gland. In the process of cadmium accumulation, there was an increase in lipid peroxidation products (malondialdehyde and lipofuscin) and a reduction in the total oxiradical scavenging capacity (TOSC). Cadmium induces oxidative stress in molluscan tissues through damage to the antioxidation system. Thus, TOSC can provide a useful biochemical indicator of early pathological changes in the cell or the organism, as well as of the environmental effects of heavy metal pollution.

Manila clam Venerupis philippinarum as a biomonitor to metal pollution

“…Metal contaminants can be effi ciently accumulated by marine organisms, especially bivalves (e.g. mussels, oysters and clams), resulting in many adverse effects to either marine organisms or ecosystems (Regoli et al, 1998;Dovzhenko et al, 2005;Sokolova et al, 2005;Felten et al, 2008;Leung et al, 2011;Thompson et al, 2011). Furthermore, the accumulated metals in organisms can be transferred into human bodies through consumption of contaminated seafood.…”

“…Cadmium can enter cells through calcium (Ca) channels and can inactivate many important enzymes by competing for the catalytic sites of other metals (Bouilly et al, 2006;Chang et al, 2009). Furthermore, Cd induces oxidative stresses by producing reactive oxygen species (ROS), which cause damage to biological molecules such as lipids, proteins and DNA (Chappie et al, 1997;Dovzhenko et al, 2005). Although zinc (Zn) is an essential element for organisms, excessive Zn can induce potential toxicities such as genotoxicity and immunotoxicity resulting in deleterious effects on fertilization, sexual maturity, and growth of the organisms (Münzinger et al, 1988;Ballatori et al, 2002;Murphy et al, 2011).…”

Effects of heavy metals on the expression of a zinc-inducible metallothionein-III gene and antioxidant enzyme activities in Crassostrea gigas

“…Among these contaminants, heavy metals can be accumulated by the aquatic organisms and cause many adverse effects on their physiological reactions (Dovzhenko et al 2005;Li et al 1967;Felten et al 2008;Viselina and Luk'anova 2000;Sokolova et al 2005). For example, cadmium (Cd) is a nonessential heavy metal contaminant that accompanies zinc mineral, and is released into the environment by mining, refining and plating processes (Choi et al 2007).…”

“…For example, cadmium (Cd) is a nonessential heavy metal contaminant that accompanies zinc mineral, and is released into the environment by mining, refining and plating processes (Choi et al 2007). Cadmium can inactivate many important enzymes by competing the catalytic sites of other metals (Chang et al 2009;Bouilly et al 2006;Dhavale et al 1988;Bandyopadhyay et al 1997), and induce oxidative stresses which cause damages to many important biological molecules including lipid, protein, DNA in aquatic organisms (Dovzhenko et al 2005;Chappie 1997). In addition, some trace essential metal, such as zinc, when the concentration surpasses the quantity demanded, could displace other trace metals and interfere with the normal metabolism pathways, which would result in deleterious effects on fertilization, sexual maturity and growth of the organisms (Münzinger and Guarducci 1988;Murphy et al 2011;Ballatori 2002).…”

Responses of thioredoxin 1 and thioredoxin-related protein 14 mRNAs to cadmium and copper stresses in Venerupis philippinarum

“…Cadmium (Cd) and copper (Cu) are two severe heavy metal contaminants along the Bohai coast (Mao et al, 2009;Peng et al, 2009). Both Cd and Cu have been demonstrated to be toxic to marine bivalves and can strongly affect their physiological status by causing oxidative stress (Isani et al, 2003;Dovzhenko et al, 2005). It has been well acknowledged that the antioxidant enzymes such as SOD, Se-GPx and catalase worked cooperatively against oxidative stress, and their activities have been detected in many mollusks (Isani et al, 2003;Abele and Puntarulo, 2004;Franco et al, 2006).…”