Cadmium induces Interleukin-8 production via NF-κB activation in the human intestinal epithelial cell, Caco-2

Hyun, Ja Shil; Satsu, Hideo; Shimizu, Makoto

doi:10.1016/j.cyto.2007.02.011

Cited by 51 publications

(30 citation statements)

References 33 publications

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“…MTs, glutathione-S-transferase or heme oxygenase-1) [232,251,252], anti-apoptotic and/or survival genes (e.g. the ATP-binding cassette xenobiotic transporter ABCB1 and caspase inhibitory protein-2) [253,254], intercellular adhesion molecule 1 (ICAM-1) [255] and the inflammatory cytokine IL-8 [256]. Interestingly, NF-B activation was also demonstrated by EMSA of lung tissues following in vivo intranasal instillation of Cd 2+ [257].…”

Section: Evasion Of Apoptosismentioning

confidence: 72%

The Role of Wnt/Beta-Catenin Signaling in Renal Carcinogenesis: Lessons from Cadmium Toxicity Studies

Thévenod¹,

Chakraborty

2010

CMM

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Wnt/beta-catenin signaling plays a crucial role during embryogenesis. However, this signaling pathway also plays a role in normal adult tissues and in carcinogenesis, including cadmium (Cd2+) induced nephrocarcinogenesis, which is the topic of this review. Wnt/beta-catenin signaling is tightly regulated in mature epithelia to balance cell proliferation, differentiation and death. This is accomplished by modulating phosphorylation of the multifunctional protein beta-catenin which in turn determines its preference for a particular fate, i.e. cell-cell adhesion by binding to E-cadherin, proteasomal degradation, or co-activation of the transcription factor Tcf/Lef. The pivotal role of beta-catenin is not limited to Wnt signaling, but can be challenged by other transcription factors under stress conditions (e.g. FOXO, HIF-1alpha, NF-kappaB, c-jun), where beta-catenin acts as a molecular switch in response to the cellular redox status. Aberrant Wnt/beta-catenin signaling can contribute to carcinogenesis of intestinal, lung or kidney epithelia, either by mutations of its signaling components and/or disruption of linked signaling networks. The nephrotoxic metal Cd2+ causes renal cancer in humans. Because it is not genotoxic Cd2+ is thought to induce mutations and carcinomas indirectly: Possible mechanisms include oxidative stress, inhibition of DNA repair, aberrant gene expression, deregulation of cell proliferation, resistance to apoptosis, and/or disruption of cell adhesion. Wnt signaling may contribute to Cd2+ carcinogenesis because Cd2+ disrupts the junctional E-cadherin/beta-catenin complex, resulting in excessive nuclear translocation of beta-catenin and activation of Tcf4. Up-regulation of target genes of the beta-catenin/Tcf4 complex, such as c-myc, cyclin D1 and the multidrug transporter P-glycoprotein (MDR1/ABCB1), leads to increased proliferation, evasion of apoptosis, adaptation to Cd2+ toxicity and thereby promotes the selection of mutated and pre-neoplastic cells.

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Section: Evasion Of Apoptosismentioning

confidence: 72%

The Role of Wnt/Beta-Catenin Signaling in Renal Carcinogenesis: Lessons from Cadmium Toxicity Studies

Thévenod¹,

Chakraborty

2010

CMM

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“…It has been reported that oxidative stress induced by xenobiotics, including Cd, can cause necrosis or apoptosis of the entero- cytes, trigger an inflammatory response, and disrupt the tight junctions in the intestines (22,(43)(44)(45), and these adverse effects could be reversed by antioxidants (46)(47)(48). On the other hand, other studies have demonstrated that probiotics can protect against intestinal barrier disruption and decrease intestinal permeability by alleviating oxidative stress in animals (49,50).…”

Section: Discussionmentioning

confidence: 99%

“…The dose of Cd exposure was 50 M CdCl 2 , selected on the basis of data from our preliminary experiment (see Fig. S1 in the supplemental material) and from the literature (22,23) to correspond to a moderate toxic effect of Cd on intestinal epithelial cells.…”

Section: Methodsmentioning

confidence: 99%

Oral Administration of Probiotics Inhibits Absorption of the Heavy Metal Cadmium by Protecting the Intestinal Barrier

Zhai

Tian

Zhang

et al. 2016

Appl Environ Microbiol

170

105

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The heavy metal cadmium (Cd) is an environmental pollutant that causes adverse health effects in humans and animals. Our previous work demonstrated that oral administration of probiotics can significantly inhibit Cd absorption in the intestines of mice, but further evidence is needed to gain insights into the related protection mode. The goal of this study was to evaluate whether probiotics can inhibit Cd absorption through routes other than the Cd binding, with a focus on gut barrier protection. In the in vitro assay, both the intervention and therapy treatments of

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“…We have found that cadmium, a heavy metal known as a contaminant in many agricultural products, induces inflammatory reactions in IECs. 77,78) These stress factors induce stimulation of immune cells in the intestinal epithelium. The mild activation of immune cells is thought to be an adaptive response to risk factors, and is called controlled inflammation.…”

Section: Inflammatory Bowel Diseasesmentioning

confidence: 99%

Interaction between Food Substances and the Intestinal Epithelium

Shimizu

2010

Bioscience, Biotechnology, and Biochemistry

Self Cite

130

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The small intestine is an organ responsible for nutrient absorption, barrier functions, signal recognition/transduction, and the production of bioactive compounds. These functions are known to be regulated by such factors as hormones and cytokines, but substances contained in the daily diet are also thought to play roles as major modulators of intestinal functions. Intestinal epithelial cells (IECs), which form a monolayer covering the inside surface of the intestinal tract, are particularly important in this modulation, because they directly interact with intestinal contents, including food substances, their digests, and gut microbial components. Using cell-based in vitro assays, we investigated the food-IEC interactions at the cellular and molecular levels, and found that a variety of food substances affected the transporter activity, tight junction permeability, metabolic enzyme expression, immune functions, and so on. Modulation of the intestinal functions by dietary substances is therefore essential to promote health.

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Cadmium induces Interleukin-8 production via NF-κB activation in the human intestinal epithelial cell, Caco-2

Cited by 51 publications

References 33 publications

The Role of Wnt/Beta-Catenin Signaling in Renal Carcinogenesis: Lessons from Cadmium Toxicity Studies

The Role of Wnt/Beta-Catenin Signaling in Renal Carcinogenesis: Lessons from Cadmium Toxicity Studies

Oral Administration of Probiotics Inhibits Absorption of the Heavy Metal Cadmium by Protecting the Intestinal Barrier

Interaction between Food Substances and the Intestinal Epithelium

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