Caffeic acid attenuates neuronal damage, astrogliosis and glial scar formation in mouse brain with cryoinjury

Zhang, Lei; Zhang, Weiping; Chen, Keda; Qian, Xiao-Dong; Fang, San‐Hua; Wei, Er-Qing

doi:10.1016/j.lfs.2006.09.039

Cited by 43 publications

(27 citation statements)

References 47 publications

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“…For example, CAPE/caffeic acid has been reported to protect the brain against induced diabetes, quinolinic acid-induced brain damage, aluminuminduced toxicity, neonatal hypoxia, and transient focal ischemia (Celik and Erdogan, 2008;Kalonia et al, 2009;Khan et al, 2007;Wei et al, 2004;Yang et al, 2008;Zhou et al, 2006). Caffeic acid has also been reported to reduce lesion area and glial scar formation following cryoinjury in mice (Zhang et al, 2007). Our finding that CAPE reduces cortical tissue loss is consistent with these studies.…”

Section: Discussionsupporting

confidence: 90%

Caffeic Acid Phenethyl Ester Protects Blood–Brain Barrier Integrity and Reduces Contusion Volume in Rodent Models of Traumatic Brain Injury

Zhao¹,

Pati

Redell³

et al. 2012

Journal of Neurotrauma

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A number of studies have established a deleterious role for inflammatory molecules and reactive oxygen species (ROS) in the pathology of traumatic brain injury (TBI). Caffeic acid phenethyl ester (CAPE) has been shown to exert both antioxidant and anti-inflammatory effects. The primary objective of the present study was to examine if CAPE could be used to reduce some of the pathological consequences of TBI using rodent models. Male Sprague-Dawley rats and C57BL/6 mice were subjected to controlled cortical impact (CCI) injury. Blood -brain barrier (BBB) integrity was assessed by examining claudin-5 expression and the extravasation of Evans blue dye. The effect of post-injury CAPE administration on neurobehavioral function was assessed using vestibulomotor, motor, and two hippocampus-dependent learning and memory tasks. We report that post-TBI administration of CAPE reduces Evans blue extravasation both in rats and mice. This improvement was associated with preservation of the levels of the tight junction protein claudin-5. CAPE treatment did not improve performance in either vestibulomotor/motor function (tested using beam balance and foot-fault tests), or in learning and memory function (tested using the Morris water maze and associative fear memory tasks). However, animals treated with CAPE were found to have significantly less cortical tissue loss than vehicle-treated controls. These findings suggest that CAPE may provide benefit in the treatment of vascular compromise following central nervous system injury.

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Section: Discussionsupporting

confidence: 90%

Caffeic Acid Phenethyl Ester Protects Blood–Brain Barrier Integrity and Reduces Contusion Volume in Rodent Models of Traumatic Brain Injury

Zhao¹,

Pati

Redell³

et al. 2012

Journal of Neurotrauma

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“…Phenolic compounds are well known to have antioxidant, anti-inflammatory, and anti-apoptotic effects, then they have been reported to inhibit neurotoxin-induced damages, resulting neuroprotection (Zhao, 2009; Joseph et al ., 2010). Chlorogenic acid and caffeic acid have a neuro-protective effect against methylglyoxal or cryo-injury via anti-apoptotic and antiinflammatory activities (Zhang et al ., 2007; Huang et al ., 2008). Also, chlorogenic acid has anti-amnesic effect via inhibition of AChE activity (Kwon et al ., 2010).…”

Section: Discussionmentioning

confidence: 99%

Houttuynia cordata Improves Cognitive Deficits in Cholinergic Dysfunction Alzheimer’s Disease-Like Models

Huh

Kim

Park

et al. 2014

Biomolecules & Therapeutics

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Cognitive impairment is a result of dementia of diverse causes, such as cholinergic dysfunction and Alzheimer’s disease (AD). Houttuynia cordata Thunb. (Saururaceae) has long been used as a traditional herbal medicine. It has biological activities including protective effects against amyloid beta (Aβ) toxicity, via regulation of calcium homeostasis, in rat hippocampal cells. To extend previous reports, we investigated the effects of water extracts of H. cordata herb (HCW) on tauopathies, also involving calcium influx. We then confirmed the effects of HCW in improving memory impairment and neuronal damage in mice with Aβ-induced neurotoxicity. We also investigated the effects of HCW against scopolamine-induced cholinergic dysfunction in mice. In primary neuronal cells, HCW inhibited the phosphorylation of tau by regulating p25/p35 expression in Aβ-induced neurotoxicity. In mice with Aβ-induced neurotoxicity, HCW improved cognitive impairment, as assessed with behavioral tasks, such as novel object recognition, Y-maze, and passive avoidance tasks. HCW also inhibited the degeneration of neurons in the CA3 region of the hippocampus in Aβ-induced neurotoxicity. Moreover, HCW, which had an IC50 value of 79.7 μg/ml for acetylcholinesterase inhibition, ameliorated scopolamine-induced cognitive impairment significantly in Y-maze and passive avoidance tasks. These results indicate that HCW improved cognitive impairment, due to cholinergic dysfunction, with inhibitory effects against tauopathies and cholinergic antagonists, suggesting that HCW may be an interesting candidate to investigate for the treatment of AD.

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“…It was reported that compound 3, caffeic acid has protective effects on chemical-induced hepatotoxicity in rodents, β-amyloid-induced neurotoxicity and neuronal damage in mouse brain (Janbaz et al, 2004;Zhang et al, 2007;Sul et al, 2009). Recently, Compound 7, quercetin-3-O-α-L-rhamnopyranoside was reported the protective effect against hydrogen peroxideinduced dysfunction in osteoblastic MC3T3-E1 cells (Choi, 2010), and lipid peroxidation (Wagner et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

Antioxidative Constituents of the Aerial Parts of Galium spurium

Yang¹,

Park²,

Ahn³

et al. 2011

Biomolecules and Therapeutics

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Reactive oxygen species (ROS), in the form of superoxide anion(O 2 − ), hydroxyl radical (·OH) and hydrogen peroxide (H 2 O 2 ), are generated in living organisms through many pathways (Chung et al., 2005). An imbalance between production of ROS and their elimination in the organisms cause oxidative stress (Monika et al., 2010). Oxidative stress has been implicated as a possible factor in the etiology of several human diseases, including cancer, cardiovascular disease, Alzheimer's disease and aging (Suganya et al., 2007). Antioxidants are the important defense factors against oxidative stress caused by ROS. However, the use of synthetic antioxidant components, such as butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT), has been limited because of their possible toxic and carcinogenic effects (Branen, 1975). Thus, there is a growing interest in fi nding natural herbal plants with low in toxicity and high in radical scavenging activity (Branen, 1975). In the course of screening for antioxidant from Korean natural plants by measuring the radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH), a total extract of the Galium spurium L. (Rubiaceae) was found to show a potent antioxidant activity. G. spurium is annual or biannual plant. Phytochemical studies on the genus have shown it to be chemically diverse, yielding among others, triterpenoid saponins, iridoidAs part of an ongoing search for natural plants with antioxidant compounds by measuring the radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH), a total extract of the twigs of Galium spurium L. (Rubiaceae) was found to show potent antioxidant activity. Subsequent activity-guided fractionation of the methanolic extract led to the isolation of nine compounds, asperulosidic acid methyl ester (1), asperuloside (2), caffeic acid ( (8), and quercetin (9). Their structures were elucidated by spectroscopic studies. Compounds 1, 3-8 were isolated for the fi rst time from this plant. Among them, compounds 3 and 9 showed the signifi cant radical scavenging effects on DPPH, and compounds 3 and 7 showed the potent ribofl avin originated superoxide quenching activities. et al., 2000). Some iridoids (Deliorman et al., 2001), anthraquinones (Koyama et al., 1993) and fl avonoids (Cai et al., 2009) were analyzed from G. spurium. Its aerial parts have been used for the treatment of the bones and sinews pain and hematuria. Crude extract of G. spurium was also used as a anticancer agent in folk medicine. It has been reported to have immunostimulant and anti-tumor activity (Yoon et al., 2005). However, information concerning the antioxidant activity of G. spurium is unavailable. This paper deals with the isolation and structural characterization of these compounds and their scavenging activity of the stable DPPH free radical and superoxide quenching activities.

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Caffeic acid attenuates neuronal damage, astrogliosis and glial scar formation in mouse brain with cryoinjury

Cited by 43 publications

References 47 publications

Caffeic Acid Phenethyl Ester Protects Blood–Brain Barrier Integrity and Reduces Contusion Volume in Rodent Models of Traumatic Brain Injury

Caffeic Acid Phenethyl Ester Protects Blood–Brain Barrier Integrity and Reduces Contusion Volume in Rodent Models of Traumatic Brain Injury

Houttuynia cordata Improves Cognitive Deficits in Cholinergic Dysfunction Alzheimer’s Disease-Like Models

Antioxidative Constituents of the Aerial Parts of Galium spurium

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