2020
DOI: 10.1016/j.jsps.2020.02.005
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Caffeine induces neurobehavioral effects through modulating neurotransmitters

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Cited by 76 publications
(42 citation statements)
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“…Thus, both in animal and human studies, changes in dopaminergic systems have been observed after caffeine exposure [ 201 ]. Different studies suggest that caffeine increases extracellular dopamine concentrations [ 202 ], as well as the expression of dopaminergic receptors [ 203 ] and transporters, which leads to an improvement of cognitive dysfunction and attention [ 204 ].…”
Section: Coffee and The Brain–gut Axismentioning
confidence: 99%
“…Thus, both in animal and human studies, changes in dopaminergic systems have been observed after caffeine exposure [ 201 ]. Different studies suggest that caffeine increases extracellular dopamine concentrations [ 202 ], as well as the expression of dopaminergic receptors [ 203 ] and transporters, which leads to an improvement of cognitive dysfunction and attention [ 204 ].…”
Section: Coffee and The Brain–gut Axismentioning
confidence: 99%
“…Caffeine maintains a higher dopamine concentration especially in those brain areas linked with “attention.” Depending on the neurotransmitter system, caffeine can affect different brain areas with different functions (Meeusen et al, 2013 ). Usually, caffeine has delayed effect about 3–4 h of half-life (Knutti et al, 1981 , 1982 ; Nehlig, 2016 ), caffeine’s behavioral effects and the significant increase in psychomotor performance it causes have been documented in a large body of literature, in addition to improvements in attention- (Temido-Ferreira et al, 2019 ; Alasmari, 2020 ; Franceschini et al, 2020 ; Irwin et al, 2020 ; Jahrami et al, 2020 ), mood-, and vigor-based tasks (Dietz and Dekker, 2017 ; Shabir et al, 2018 ; Alasmari, 2020 ). Moreover, Beaumont et al ( 2005 ) found that the action of caffeine both shortened response times and reduced the number of errors on psychomotor tests, which indicates that caffeine has a global action on information processing and divided attention management (Beaumont et al, 2005 ; Wilhelmus et al, 2017 ).…”
Section: Introductionmentioning
confidence: 99%
“…Caffeine's main action mechanism is the antagonism of the A1, A2, and A3 adenosine receptors present in different areas of the CNS, including the nucleus accumbens, striatum, hypothalamus, cerebral cortex, hippocampus, olfactory bulb and tubercle (Salamone and Correa, 2012;Simoes et al 2016). This antagonism participates in inhibiting or exciting the G protein (pG) by altering phosphorylation of cyclic AMP and, as a result, modifying the flow of intracellular calcium (Kolahdouzan and Hamadeh, 2016) and the systems that modulate dopamine and glutamate release (Solinas et al 2002;Villanueva-García 2007;Villegas and Villanueva-García 2016;Lopes et al 2019;Alasmari et al 2020). The physiological effects of caffeine depend on the density of the receptors and the region of the CNS where they are found ( Figure 1).…”
Section: Pharmacodynamic Effects Of Caffeinementioning
confidence: 99%
“…This has been explained by the possible interaction of this receptor with memory and behavioral disorders. Caffeine may perform a neuroprotector function due to the increase in extracellular glutamate (Alasmari, 2020). Instilling caffeine at concentrations of 50 µM can facilitate synaptic transmission by 40% and reduce the amplitude of long-term J Anim Behav Biometeorol (2020) 8:298-307 potentializing by 35%, in association with phenomena of enhanced neuronal plasticity and the blocking of adenosine receptors (Lopes et al 2019).…”
Section: Effects In Neurodegenerative Diseasesmentioning
confidence: 99%
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