Caffeine vehiculation into alpha-zirconium phosphate: a multifunctional intercalation product and its application for modified topical release

Bastianini, Maria; Sisani, Michele; Petracci, Annarita; Guida, Irene Di; Faffa, Caterina; Cardellini, Fabio

doi:10.1039/d0ma00729c

Cited by 4 publications

(1 citation statement)

References 39 publications

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“…Caffeine has been proven to be an efficient therapeutic and cosmetic agent. [1] For instance, caffeine can be used for apnea treatment in premature infants or as a coadjutant for pain management. [2] Recently, literature works demonstrated the efficacy of caffeine as an antiapoptotic, anti-inflammatory, DOI: 10.1002/mame.202300352 and antioxidant and its crucial activities in the treatment of neurodegenerative disorders, such as Parkinson's and Alzheimer's disease.…”

Section: Introductionmentioning

confidence: 99%

PBAT/PLA Films and Supercritical Impregnation of Caffeine for Potential Application in Anticellulite Tools

Liparoti,

Mottola,

De Marco

et al. 2023

Macro Materials & Eng

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Topical administration is the preferred route for the controlled release of active compounds since it reduces side effects typical of other administration methods. The use of polymer blends is a way to modulate drug release from a topical device. The blends ensure modulation of a wide range of properties, such as mechanical properties, water sorption, and degradation. This paper proposes blends of poly(lactide acid) (PLA), and Poly(butylene adipate‐co‐terephthalate) (PBAT), for the topical release of caffeine, a molecule with anti‐inflammatory, antioxidant, and anticellulite activities. PBAT/PLA blends are optimized for compatibility between the two polymers, mechanical properties, and drug release rate. Blends with a higher amount of PBAT show the best performance regarding polymer compatibility. The blends undergo supercritical CO2‐assisted caffeine impregnation. This process assures homogeneous dispersion of caffeine into the polymer matrix. The ratios 45/55 and 55/45 PBAT/PLA show the best performance in terms of caffeine release (complete caffeine release within 25 h). Caffeine is released into three steps: a burst effect due to the caffeine dispersed over the film surface, a slower release due to the caffeine dispersed in the polymer matrix, and a fast release due to the increase of polymer degradation rate induced by caffeine presence.

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Section: Introductionmentioning

confidence: 99%

PBAT/PLA Films and Supercritical Impregnation of Caffeine for Potential Application in Anticellulite Tools

Liparoti,

Mottola,

De Marco

et al. 2023

Macro Materials & Eng

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Dual-effects of caffeinated hyalurosomes as a nano-cosmeceutical gel counteracting UV-induced skin ageing

Elsheikh

Gaafar

Khattab

et al. 2023

International Journal of Pharmaceutics: X

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Recent advances and perspectives for intercalation layered compounds. Part 2: applications in the field of catalysis, environment and health

Bisio,

Brendlé,

Cahen

et al. 2024

Dalton Trans.

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Caffeine vehiculation into alpha-zirconium phosphate: a multifunctional intercalation product and its application for modified topical release

Abstract: Zirconium phosphate is able to intercalate basic molecules and it is an effective drug carrier that can be used to project slow release for topical applications.

Cited by 4 publications

References 39 publications

PBAT/PLA Films and Supercritical Impregnation of Caffeine for Potential Application in Anticellulite Tools

PBAT/PLA Films and Supercritical Impregnation of Caffeine for Potential Application in Anticellulite Tools

Dual-effects of caffeinated hyalurosomes as a nano-cosmeceutical gel counteracting UV-induced skin ageing

Recent advances and perspectives for intercalation layered compounds. Part 2: applications in the field of catalysis, environment and health

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