Cajanus indicus leaf protein: Beneficial role in experimental organ pathophysiology. A review

Sarkar, Kamalesh; Sil, Parames C.

doi:10.1016/j.pathophys.2011.05.001

Cited by 8 publications

(2 citation statements)

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“…The most important bioactive ingredients of plants are: flavonoids, tannins, alkaloids and phenolic compounds [16]. A number of medicinal plants and herbs such as Silybum marianum [17], Terminalia arjuna [18]–[21], Cajanus indicus [22]–[29], Phyllanthus niruri [30]–[39], Pithecellobium dulce [40], [41], etc. in India and other parts of the World are natural sources of antioxidants that act as the first line of defense against free radical damage and are considered to be important in maintaining optimum health and happiness.…”

Section: Introductionmentioning

confidence: 99%

Mangiferin, a Natural Xanthone, Protects Murine Liver in Pb(II) Induced Hepatic Damage and Cell Death via MAP Kinase, NF-κB and Mitochondria Dependent Pathways

2013

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One of the most well-known naturally occurring environmental heavy metals, lead (Pb) has been reported to cause liver injury and cellular apoptosis by disturbing the prooxidant-antioxidant balance via oxidative stress. Several studies, on the other hand, reported that mangiferin, a naturally occurring xanthone, has been used for a broad range of therapeutic purposes. In the present study, we, therefore, investigated the molecular mechanisms of the protective action of mangiferin against lead-induced hepatic pathophysiology. Lead [Pb(II)] in the form of Pb(NO3)2 (at a dose of 5 mg/kg body weight, 6 days, orally) induced oxidative stress, hepatic dysfunction and cell death in murine liver. Post treatment of mangiferin at a dose of 100 mg/kg body weight (6 days, orally), on the other hand, diminished the formation of reactive oxygen species (ROS) and reduced the levels of serum marker enzymes [alanine aminotranferase (ALT) and alkaline phosphatase (ALP)]. Mangiferin also reduced Pb(II) induced alterations in antioxidant machineries, restored the mitochondrial membrane potential as well as mutual regulation of Bcl-2/Bax. Furthermore, mangiferin inhibited Pb(II)-induced activation of mitogen-activated protein kinases (MAPKs) (phospho-ERK 1/2, phosphor-JNK phospho- p38), nuclear translocation of NF-κB and apoptotic cell death as was evidenced by DNA fragmentation, FACS analysis and histological assessment. In vitro studies using hepatocytes as the working model also showed the protective effect of mangiferin in Pb(II) induced cytotoxicity. All these beneficial effects of mangiferin contributes to the considerable reduction of apoptotic hepatic cell death induced by Pb(II). Overall results demonstrate that mangiferin exhibit both antioxidative and antiapoptotic properties and protects the organ in Pb(II) induced hepatic dysfunction.

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Section: Introductionmentioning

confidence: 99%

Mangiferin, a Natural Xanthone, Protects Murine Liver in Pb(II) Induced Hepatic Damage and Cell Death via MAP Kinase, NF-κB and Mitochondria Dependent Pathways

2013

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“…In 1962, researchers first used EALP for human consumption tests and the results showed that EALP has a similar biological value to that of milk and after taking it, children's height, weight and blood characteristics improved . Each 100 g of EALP could provide 1667.4 kJ heat, 60 g protein, 0.8 mg calcium, 50 mg iron, 1.4 µg of β‐carotene . Devadas et al .…”

Section: Alfalfa Leaf Proteinmentioning

confidence: 99%

A short review on the research progress in alfalfa leaf protein separation technology

Zhang

Grimi

Jaffrin

et al. 2017

J. Chem. Technol. Biotechnol

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Alfalfa leaf protein constitutes an important food ingredient and is widely used in food technology. Due to high nutritive value and high proteins content, alfalfa is widely used in animal and human food. Conventionally, industrial leaf protein production from alfalfa requires complex processing and high separation temperature (90 °C), which causes high energy cost, release of sensitive elements and protein denaturation. To overcome these issues, developing novel separation technologies with low energy consumption and high yield and purity is of paramount importance to meet the requirements of green separation. In this review, some separation methods including acid heating method, pH method, salting method, organic solvent method, fermentation method and membrane separation are described. Among them, membrane separation has the best performance. The feasibility of adopting conventional and new promising technology (membrane) to recover leaf protein from plant food materials is discussed from an environmental and economical point of view. © 2017 Society of Chemical Industry

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Natural Bioactive Molecules

Ghosh

Sil

2015

Studies in Natural Products Chemistry

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Cajanus indicus leaf protein: Beneficial role in experimental organ pathophysiology. A review

Cited by 8 publications

References 73 publications

Mangiferin, a Natural Xanthone, Protects Murine Liver in Pb(II) Induced Hepatic Damage and Cell Death via MAP Kinase, NF-κB and Mitochondria Dependent Pathways

Mangiferin, a Natural Xanthone, Protects Murine Liver in Pb(II) Induced Hepatic Damage and Cell Death via MAP Kinase, NF-κB and Mitochondria Dependent Pathways

A short review on the research progress in alfalfa leaf protein separation technology

Natural Bioactive Molecules

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