Calcitonin and vitamin D3 have high therapeutic potential for improving diabetic mandibular growth

Abbassy, Mona Aly; Watari, Ippei; Bakry, Ahmed; Ono, Takashi; Hassan, Ali

doi:10.1038/ijos.2015.47

Cited by 9 publications

(6 citation statements)

References 32 publications

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“…Periodontitis results when AGEs react with receptors of advanced glycosylation end products (RAGEs), in the periodontal tissues. Furthermore, animal studies suggest that DM not only induces higher alveolar bone resorption but also alters orthodontic tooth movement [ 14 , 15 ]. In addition, studies suggest that DM inhibits bone remodeling around the teeth undergoing orthodontic tooth movement [ 16 , 17 ].…”

Section: Reviewmentioning

confidence: 99%

Influence of uncontrolled diabetes mellitus on periodontal tissues during orthodontic tooth movement: a systematic review of animal studies

et al. 2017

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Diabetes mellitus (DM) may adversely affect periodontal tissues during orthodontic tooth movement (OTM). The aim of this review is to systematically analyze and review animal studies investigating the effect of DM on periodontal tissues during OTM. An electronic search was conducted via PubMed/Medline, Google Scholar, Embase, ISI Web of Knowledge, and Cochrane Central Register of Controlled Trials (CONTROL) using the keywords “diabetes,” “orthodontics,” and “tooth movement” for studies published between January 2000 and August 2016. After elimination of duplicate items, the primary search resulted in 89 articles. After exclusion of irrelevant articles on the basis of abstract and title, full texts of 25 articles were read to exclude additional irrelevant studies. Seven animal studies were included in this review for qualitative analysis. When compared to healthy animals, more bone resorption and diminished bone remodeling were observed in diabetic animals in all studies. Furthermore, DM decreased the rate of OTM in one study, but in another study, DM accelerated OTM. DM may adversely affect bone remodeling and tooth movement during application of orthodontic forces. However, a number of potential sources of bias and deficiencies in methodology are present in studies investigating the association between OTM and DM. Hence, more long-term and well-designed studies are required before the exact mechanism and impact of DM on outcomes of orthodontic treatment is understood.

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Section: Reviewmentioning

confidence: 99%

Influence of uncontrolled diabetes mellitus on periodontal tissues during orthodontic tooth movement: a systematic review of animal studies

et al. 2017

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“…The availability of more effective osteoporosis drugs, such as bisphosphonates, has led to CT therapy primarily being used for the short‐term mediation of acute pain from osteoporosis, although combination treatments involving CT have shown efficacy in mediating both hypercalcemia and bone quality under circumstances in which other treatments were ineffective . In particular, CT has seen significant use as a therapeutic for the treatment of postmenopausal osteoporosis ,,,.…”

Section: Current Calcitonin Therapymentioning

confidence: 99%

Structural Biology of Calcitonin: From Aqueous Therapeutic Properties to Amyloid Aggregation

Kamgar-Parsi

Tolchard

Habenstein

et al. 2016

Israel Journal of Chemistry

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Under appropriate conditions, peptides and proteins can assemble from their native state into prefibrillar oligomers and then mature into fibrillar aggregates. This transition forms the molecular basis of several pathologies, often related to the deposition of these amyloid fibrils. Several hormone peptides involved in fundamental biological processes have the tendency to self‐assemble into amyloid fibrils, resulting in a loss of their native functions, and more importantly, entailing devastating consequences, such as the formation of amyloid depositions. Calcitonin is a 32 amino‐acid hormone peptide that can be considered a molecular paradigm for the central events associated with hormone misfolding. Calcitonin in its native form is involved in various physiological functions, including mediating calcium homeostasis and maintaining bone structure. It is the latter function that has motivated the use of calcitonin as an aqueous therapeutic agent for the treatment of bone‐related pathologies such as osteoporosis and Paget's disease. Despite some success as a therapeutic, calcitonin's ability to control these diseases is limited by its aggregation along the canonical amyloid aggregation pathway, compromising its long‐term stability as a therapeutic agent. A better understanding of the misfolding process would not only provide the structural basis to improve calcitonin's long‐term stability and activity as a therapeutic, but also provide valuable insights into pathological aggregation of other amyloids. In this work, we review the physiological roles of calcitonin, its structure, and aggregation process, and consider the effects of calcitonin's structure on its role as a therapeutic.

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“…Relatively of "the stomatognathic system", Mona et al suggested that supplementation of vitamin D combined with an antiresorptive agent (calcitonin) may enhance mandibular growth and potentially produce a beneficial effect on orthodontic treatment for stunted mandibular bone growth problems [70].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Vitamin D (25OHD), Bone Alkaline Phosphatase (BALP), Serum Calcium, Serum Phosphorus, Ionized Calcium in Patients with Mandibular Third Molar Impaction. An Observational Study

et al. 2021

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The aim of this study was to evaluate the levels of vitamin D (25OHD) and other bone biomarkers in patients with third molar impaction (TMI). Thirty males and 30 females with unilateral or bilateral impacted mandibular third molar, and 15 males and 15 females as a control group (CG) were recruited. Rx-OPT was used to evaluate dental position and Pederson index to measure the difficulty of the intervention. Bone biomarkers were measured through blood venous sample in TMI group and CG. Mann-Whitney test, Pearson’s correlation coefficient, linear regression model were used to compare the different parameters in the two groups. 25OHD showed lower values in TMI group than in CG (p < 0.05) with values significantly lower in bilateral impaction (p < 0.05). Pearson’s coefficient for 25OHD presented a negative correlation with the Pederson index (ρ = −0.75). Bone alkaline phosphatase (BALP) showed significantly lower dosage in TMI group than CG (p = 0.02), Pearson’s coefficient for BALP presented a negative correlation with the Pederson index. Serum calcium, serum phosphorus, ionized calcium levels in TMI and CG groups were similar and Mann-Whitney test did not significantly differ between TMI and CG. TMI could be a sign of vitamin D deficiency and of low BALP levels that should be investigated.

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Calcitonin and vitamin D3 have high therapeutic potential for improving diabetic mandibular growth

Cited by 9 publications

References 32 publications

Influence of uncontrolled diabetes mellitus on periodontal tissues during orthodontic tooth movement: a systematic review of animal studies

Influence of uncontrolled diabetes mellitus on periodontal tissues during orthodontic tooth movement: a systematic review of animal studies

Structural Biology of Calcitonin: From Aqueous Therapeutic Properties to Amyloid Aggregation

Evaluation of Vitamin D (25OHD), Bone Alkaline Phosphatase (BALP), Serum Calcium, Serum Phosphorus, Ionized Calcium in Patients with Mandibular Third Molar Impaction. An Observational Study

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