Calcitonin, estradiol, and hydroxyproline as parameters in the early diagnosis of involutional osteoporosis

Abstract

Bone metabolism was studied in a group of 92 subjects. A greater age-related decrease in calcitonin and estradiol concentrations exists in women than in men, though this difference was not significant; it was significant, however, when the values of the three different groups of women were compared. We present what we have called the second calcitonin phenomenon, that is, a highly significant difference in women between a second basal calcitonin level and the primary admission value. In the calcium infusion test, men considered to be osteoporotic showed a deceleration in the rapid loss of reserve calcitonin deposits.

Metabolomic Profiles Delineate Signature Metabolic Shifts during Estrogen Deficiency-Induced Bone Loss in Rat by GC-TOF/MS

“…Some research suggested that increased serum and urine levels of hydroxyproline had been demonstrated in Paget’s disease bone [52], [53]. Meanwhile, mean plasma levels of branched-chain amino acids (BCAA, leucine, isoleucine, and valine) raised rapidly in the first three week after OVX and remained significantly elevated (p<0.05 versus sham-operated controls) for the entire 24 week.…”