Calcitonin from Ultimobranchial Glands of Dogfish and Chickens

Copp, D. Harold; Cockcroft, Donald W.; Kueh, Y K

doi:10.1126/science.158.3803.924

Cited by 154 publications

(35 citation statements)

References 7 publications

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“…Estimates of the relative contributions to thyroid weight from the lateral anlage range from less than 1 to 30% in humans [7]. In non-mammal vertebrates, the embryonic thyroid and UBB develop as separate structures, thus, C cells are confined to the ultimobranchial glands derived from the UBB, where they secrete calcitonin [8].…”

Section: Embryological Development Of the Thyroid Gland And Origin Ofmentioning

confidence: 99%

Paracrine Regulation of Thyroid-Hormone Synthesis by C Cells

Fernández-Santos¹,

García-Marín²,

Utrilla³

et al. 2012

Thyroid Hormone

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Section: Embryological Development Of the Thyroid Gland And Origin Ofmentioning

confidence: 99%

Paracrine Regulation of Thyroid-Hormone Synthesis by C Cells

Fernández-Santos¹,

García-Marín²,

Utrilla³

et al. 2012

Thyroid Hormone

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“…Nonidez reported the presence of argyrophilic cytoplasmic granules C-cells and also remarked on their para-follicular location; he also hypothesized that these cells may have endocrine function (1). The term "calcitonin" was first coined by Copp and Cheney in as a substance of parathyroid origin as it was responsible for lowering serum calcium levels (2). The thyroid origin of calcitonin was first confirmed by Hirsch in 1963 andFoster in 1964 (3,4).…”

Section: Historical Perspectivementioning

confidence: 98%

C-cells and their associated lesions and conditions: a pathologists perspective

Baloch¹,

LiVolsi²

2015

TJPATH

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This paper updates the histopathology and cytopathology of thyroid tumors and proliferations derived from the para-follicular or C cells. Beginning with an historical over view, including the recognition of medullary thyroid carcinoma as a distinct histologic entity, its relationship to the hormone, calcitonin, (which was discovered in the same decade) and to thyroid C cells, medullary carcinoma and its variants are reviewed. The molecular biology of the tumors and the associated mutations in the tumors (somatic mutations) are discussed. Additionally the genetic features (germline mutations) including familial clusters and associations with other endocrine and neuroendocrine lesions are reviewed. Screening for the tumor and its precursors is included with a review of the latest American Thyroid Association guidelines for treatment as well as timing and approach to surgery. Tabular data of specific germline mutations and their relationships to tumor virulence, and prognosis are illustrated. Precursor and early C cell lesions such as C-cell hyperplasia and micro-medullary carcinoma are discussed. Difficulties and controversies in the definition of C-cell proliferations which are neoplastic and those which are "reactive" are reviewed. The entity of medullary microcarcinoma or medullary microcarcinoma is illustrated and the distinction between C cell nodules and microcarcinoma is defined using the latest available criteria. Finally the latest approved chemotherapeutic agents and their results in metastatic medullary thyroid carcinoma are included.

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“…Concerning the secretory functions of the ultimobranchial body, WATZKA (1933) suggested the possibility of an endocrine function for this organ, and CoPP et al (1967) reported the secretion of calcitonin based on their experiment.…”

Section: Discussionmentioning

confidence: 99%

“…Unlike the ultimobranchial body of mammals, that of lower vertebrates-including birds-remains independent of the thyroid gland after birth, being involved in the secretion of calcitonin, similar to the parafollicular cells (DUDLEY, 1942;SEHE,1960;CoPP et al, 1967;CHAN et al, 1969). PEARSE (1966PEARSE ( , 1968PEARSE ( , 1969 has long been advocating the amine precursor uptake and decarboxylation (APUD) theory by noting the existence of serotonin (5-HT), an amine, in addition to calcitonin in the parafollicular cells and the ultimobranchial body.…”

Section: Discussionmentioning

confidence: 99%