Calcium‐binding protein expression in peritoneal endometriosis‐associated nerve fibres

Arellano, Maria Luisa Barcena de; Münch, Sandra; Arnold, Julia; Helbig, Sina; Schneider, Achim; Mechsner, Sylvia

doi:10.1002/j.1532-2149.2013.00323.x

Cited by 7 publications

(3 citation statements)

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“…Recently, Mechsner’s group demonstrated the presence of calcium-binding proteins (calbindin, parvalbumin and calretinin), involved in calcium homeostasis, an important modulator of neuronal activity, and sensitization in neurons in peritoneal endometriosis-associated nerve fibres (Barcena de Arellano et al ., 2013b). The amount of calbindin, calretinin and parvalbumin associated-nerve fibres was significantly increased in proximal and distal areas of peritoneal endometriotic lesions compared to the healthy peritoneum.…”

Section: Nerve Fibres In Endometriosis: Human Studiesmentioning

confidence: 99%

Peripheral changes in endometriosis-associated pain

Morotti

Vincent

Brawn

et al. 2014

Human Reproduction Update

156

113

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Section: Nerve Fibres In Endometriosis: Human Studiesmentioning

confidence: 99%

Peripheral changes in endometriosis-associated pain

Morotti

Vincent

Brawn

et al. 2014

Human Reproduction Update

156

113

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“…2 However, regardless of ethnicity, the prevalence and symptoms of endometriosis are related to personal traits and other factors such as age and economic status. [3][4][5] Increased inflammatory mediators such as interleukin (IL) 1b and 6, tumor necrosis factor a, and prostaglandins 6,7 are considered to sensitize sensory neurons by stimulating the sensory nerve fibers within the ectopic lesions 8,9 and thus trigger the pain signal cascade in women with endometriosis. 10 Endometriosis pain may be considered as a kind of inflammatory and neuropathic pain.…”

Section: Introductionmentioning

confidence: 99%

Role of Brain-Derived Neurotrophic Factor in Endometriosis Pain

et al. 2018

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Brain-derived neurotrophic factor (BDNF) is a regulator for the formation and maintenance of chronic pain in various chronic disorders and has been shown to increase in the serum of women with endometriosis. However, BDNF expression in the peritoneal fluid (PF) and ectopic lesions and its role in endometriosis pain remain unclear. Thus, this study aims to determine the BDNF concentrations in serum and PFs and BDNF expression levels in ectopic lesions and endometriotic stromal cells (ESCs) of women with endometriosis (n = 60). The obtained results were then compared with those of women without endometriosis (n = 38). Brain-derived neurotrophic factor concentrations in serum and PF, as well as the BDNF expression levels in ectopic lesions and endometriotic cells, were evaluated through enzyme-linked immunosorbent assay, immunohistochemical staining, quantitative real-time polymerase chain reaction, and Western blot analysis. As a result, BDNF concentrations in serum and PF were significantly higher in women with endometriosis with pain (2284.3 ± 51.5 pg/mL, n = 23; 58.8 ± 6.4 pg/mL, n = 16) than in women with endometriosis without pain (1999.8 ± 61.1 pg/mL, n = 37; 31.7 ± 2.9 pg/mL, n = 25; P < .01). Moreover, BDNF messenger RNA (mRNA) expression levels in ectopic lesions (8.97 ± 1.44, n = 29) were significantly higher than eutopic (0.97 ± 0.14, n = 16; P < .01) and control endometrium (1.23 ± 0.19, n = 18; P < .01) and were correlated with endometriosis pain ( P < .05). Furthermore, increased BDNF mRNA and protein expression levels in ESCs induced by estradiol or interleukin 1β were removed using a phosphorylated extracellular-regulated protein kinase 1/2 inhibitor. These results suggest that BDNF may play an important role in the pathogenesis of endometriosis pain.

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“…A major source for visceral pain is associated with endometriosis, defined as the presence of functional endometrium outside the uterine cavity which can result in dysmenorrhea, dyspareunia, infertility, and severe pelvic pain [148,149]. Although the mechanism behind the pain is not clear, biopsies from patients suffering from endometriosis-related pain (ERP) show an increase in the density of sensory nerve fibers innervating the endometriotic lesions [150][151][152], including those expressing the nociceptive marker CGRP [153]. In endometriotic biopsies, the expression level of P2X3 was greater in patients compared to age-matched controls and positively correlated with pain severity [76].…”

Section: Clinical Programs Investigating P2x3-containing Receptor Antagonists In Chronic Painmentioning

confidence: 99%

P2X3-Containing Receptors as Targets for the Treatment of Chronic Pain

Krajewski

2020

Neurotherapeutics

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Current therapies for the treatment of chronic pain provide inadequate relief for millions of suffering patients, demonstrating the need for better therapies that will treat pain effectively and improve the quality of patient's lives. Better understanding of the mechanisms that mediate chronic pain is critical for developing drugs with improved clinical outcomes. Adenosine triphosphate (ATP) is a key modulator in nociceptive pathways. Release of ATP from injured tissue or sympathetic efferents has sensitizing effects on sensory neurons in the periphery, and presynaptic vesicular release of ATP from the central terminals can increase glutamate release thereby potentiating downstream central sensitization mechanisms, a condition thought to underlie many chronic pain conditions. The purinergic receptors on sensory nerves primarily responsible for ATP signaling are P2X3 and P2X2/3. Selective knockdown experiments, or inhibition with small molecules, demonstrate P2X3-containing receptors are key targets to modulate nociceptive signals. Preclinical studies have identified that P2X3-containing receptors are critical for sensory transduction for bladder function, and clinical studies have shown promise in treatment for bladder pain and pain associated with osteoarthritis. Further clinical characterization of antagonists to P2X3-containing receptors may lead to improved therapies in the treatment of chronic pain.

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Calcium‐binding protein expression in peritoneal endometriosis‐associated nerve fibres

Abstract: Calcium-binding proteins seem to be increased in endometriosis-associated nerve fibres and might play an important role in the chronic inflammatory condition and the pain pathogenesis of endometriosis.

Cited by 7 publications

References 58 publications

Peripheral changes in endometriosis-associated pain

Peripheral changes in endometriosis-associated pain

Role of Brain-Derived Neurotrophic Factor in Endometriosis Pain

P2X3-Containing Receptors as Targets for the Treatment of Chronic Pain

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