Calcium carbonate hybrid coating promotes the formation of biomimetic hydroxyapatite on titanium surfaces

Different compact hybrid Langmuir–Blodgett‐film coatings modify biomineralization and the ability of osteoblasts to grow

“…Surfaces with high Ca 21 -content by the deposition of CaCO 3 thin films have been described to diminish the initial osteoblast proliferation. 38,57 Moreover, implantation of HAp in the body initially dissolves the top surface layer of HAp to deliver Ca 21 ions until the dissolution equilibrium is reached. [58][59][60] In fact, the surface dissolution of CaP to release Ca 21 and phosphate ions in the cell-material interface directly affects the osteoblast behavior, 61 evidencing the importance in studying the Ca 21 content on CaP coatings.…”

“…The advantages are mostly related to the requirement of a relatively low‐cost equipment and use of mild conditions to create highly homogeneous and reproducible coatings. Moreover, the LB‐based technique allows the incorporation of proteins in the coating, association with polymers, and mediation of the growth of different biominerals, such as CaCO 3 thin films . Additionally, phospholipid‐mediated HAp mineralization on Ti surfaces is an approach inspired on the process of bone formation, where HAp crystals first nucleates on the lipid‐membrane inside MV's .…”

“…Moreover, the LB-based technique allows the incorporation of proteins in the coating, 32 association with polymers, 37 and mediation of the growth of different biominerals, such as CaCO 3 thin films. 38 Additionally, phospholipid-mediated HAp mineralization on Ti surfaces is an approach inspired on the process of bone formation, where HAp crystals first nucleates on the lipid-membrane inside MV's. 18,19 Being so, Ti surfaces modified with LB-films may optimize osseointegration and increase the biocompatibility of Ti because the surface mimics the structure of the cell membrane.…”

Nanomaterials and their role in bone tissue regeneration

“…Используются титановые имплантаты с покрытием из гидроксиапатита и трехмерные матриксы из полимолочной кислоты совместно с гидроксиапатитами, полученными методом 3D печати для улучшения адгезии клеточных структур [23][24][25][26][27]. Ученые из Китая установили, что материалы, изготовленные из одного гидро ксиапатита, не обладают ни биологическими свойствами кости, ни функциями стимулирования васкуляризации и ингибирования иммунного отторжения.…”

Desenvolvimento de materiais bioinspirados contendo Sr²⁺ para modificação de superfícies de Ti

“…Dessa forma, é possível simular membranas biológicas 137 e estudar efeitos de íons 138,139 , proteínas 140 e fármacos 141 na estrutura e propriedades das monocamadas apropriadas, correlacionando-os com fenômenos biológicos. Em especial, monocamadas de Langmuir são uma importante ferramenta no estudo da influência da matriz orgânica na biomineralização 85,102,142,143 . A origem dessa aplicação está na ideia de que a nucleação da fase mineral em sistemas biológicos dá-se pela correspondência estrutural entre grupos funcionais da matriz orgânica e a estrutura cristalina dos núcleos minerais em formação 144 .…”