Calcium ion diffusion from mineral trioxide aggregate through simulated root resorption defects

Özdemir, Hüseyin; Özçelik, Bahar; Karabucak, Bekir; Çehrelį, Zafer C.

doi:10.1111/j.1600-9657.2006.00512.x

Cited by 58 publications

(55 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies reported that the rate of calcium ion release of MTA was significantly compromised due to the presence of Bi 2 O 3 in its composition (6,7). However, various in vivo studies that assessed the biocompatibility of this cement (21,22) demonstrated that after 30 days, the material allowed adequate tissue repair, indicating that the alkaline pH produced by calcium ion release was maintained (22,23).…”

Section: Discussionmentioning

confidence: 98%

“…In spite of various studies demonstrating the biocompatibility (3) and bioactivity (4,5) of MTA, bismuth oxide (Bi 2 O 3 ), the inorganic compound that provides radiopacity to the cement, interferes in its hydration mechanism (6), compromising calcium ions release to the tissue (7). Therefore, the formation of hard reparative tissues on exposed pulps and the formation of a complete mineralized barrier may be a negative influence of Bi 2 O 3 in the MTA composition (8).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cytotoxicity of New Calcium Aluminate Cement (EndoBinder) Containing Different Radiopacifiers

et al. 2017

View full text Add to dashboard Cite

This study aimed to evaluate the cytotoxicity of a calcium aluminate cement (EndoBinder) containing different radiopacifiers, Bi 2 O 3 , ZnO or ZrO 2 , compared with Mineral Trioxide Aggregate (MTA). According to ISO 10993-12:2012 (E) recommendations, 0.2 g of each cement were applied in transwell inserts and placed in 24-well culture plates containing 1 mL of culture medium (DMEM). After 24 h of incubation, the extracts (DMEM containing components released from the cements) were applied to immortalized odontoblast-like MDPC-23 cells. Cell viability (MTT test), alkaline phosphatase activity (ALP), total protein production and cell morphology (Scanning Electron Microscopy -SEM) were evaluated. The volume of 50 µL of extract was used to determine the chemical elements released by the cements using Energy Dispersive Spectroscopy (EDS). The following groups were established (n=6): NC -negative control (without treatment); EB -EndoBinder without radiopacifier; EBBO -EndoBinder+Bi 2 O 3 ; EBZnO -EndoBinder+ZnO; EBZrOEndoBinder+ZrO 2 and WMTA -White MTA. Data were subjected to statistical analysis (Kruskal-Wallis test, level of significance=5%). Cells exposed to the different versions of EndoBinder presented small reduction in viability, total protein production and ALP activity, with values similar to the NC and WMTA groups (p>0.05). Different elements (C, O, Na, Al, P, Si, Cl, Bi, K) released by the cements were detected in the extracts. However, the cells had no significant changes in their morphology. EndoBinder and MTA did not affect negatively the metabolism of the odontoblastic-like cells, showing it to be cytocompatible, irrespective of the used radiopacifier.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of New Calcium Aluminate Cement (EndoBinder) Containing Different Radiopacifiers

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The calcium ion release is enhanced when calcium chloride is added as an accelerator to MTA [ 12 ]. Moreover, when MTA was placed into the root canals of teeth with simulated radicular resorption, a greater calcium ion release was detected in comparison to teeth not fi lled with MTA [ 131 ].…”

Section: Introductionmentioning

confidence: 95%

Properties of Hydrated Mineral Trioxide Aggregate

Tanomaru-Filho

Guerreiro-Tanomaru

2014

Mineral Trioxide Aggregate in Dentistry

View full text Add to dashboard Cite

MTA has been currently commercialized in two different forms, the gray (GMTA) and the white version (WMTA). In particular, the white MTA was developed due to the potential discoloration promoted by the gray version of the cement. The chemical composition of the MTAs is very similar to that of Portland cement despite the addition of components containing bismuth in the MTA's cements [ 91 , 128 ], which aims to confer radiopacity to the materials [ 34 ]. The mixture of the MTA powder with distilled water results in the formation of by-products, such as calcium hydroxide and calcium silicate hydrate gel [ 27 , 28 ] as discussed in Chap. 2 . The particular mechanism of hydration and the structure of the set material result in particular properties displayed by the set MTA.The initial pH of the MTA is approximately 10.2, but it increases to 12.5 after 3 h immersed in solution [ 177 ]. MTA has the ability to sustain high values of pH during long periods [ 75 ]. The high pH values exhibited by MTA are attributed to the constant release of calcium and the formation of calcium hydroxide.Several studies had reported release of calcium from MTA [ 12 , 74 , 131 ]. The calcium ion release is enhanced when calcium chloride is added as an accelerator to MTA [ 12 ]. Moreover, when MTA was placed into the root canals of teeth with simulated radicular resorption, a greater calcium ion release was detected in comparison to teeth not fi lled with MTA [ 131 ]. Setting TimeThe hydration of the MTA powder produces a colloidal gel, which solidifi es and results in a solid structure. MTA is prepared by mixing the powder with distilled water using a ratio of 3:1 (powder/distilled water) [ 184 ].

show abstract

“…MTA obturations in teeth with immature apices can induce apexo-genesis by stimulating the mesenchymal stem cells from the apical papilla to promote complete root maturation in the presence of periapical pathosis or abscesses [40] . Resorption : It has been shown that intracanal application of MTA can also cause release of calcium ions through dentinal tubules into External Resorption defect, which may halt the progress of resorption and favour repair potential of the surrounding tissues [41] . Recent research has demonstrated that root canal treated teeth obturated with MTA exhibit higher fracture resistance than their untreated counterparts [42] .…”

Section: Clinical Performance Studiesmentioning

confidence: 99%