Calcium phosphate glasses and glass-ceramics for medical applications

Mestral, F. de; Drew, R. A. L.

doi:10.1016/0955-2219(89)90008-3

Cited by 20 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, there is a great need to fabricate composites with controlled biodegradation, especially for bone grafting, filling or substitution [5][6][7][8]. Various attempts have been made to associate the advantageous properties of hydroxyapatite and bioactive glasses [9][10][11][12]. While pure crystalline hydroxyapatite is a fairly inert material in aqueous solutions, bioactive glasses exhibit controlled ion release depending on their chemical composition [-13-15].…”

Section: Introductionmentioning

confidence: 99%

In vitro calcium phosphate formation on SiO2-Na2O-CaO-P2O5 glass reinforced hydroxyapatite composite: a study by XPS analysis

Santos

Jha²,

Monteiro

1996

J Mater Sci: Mater Med

View full text Add to dashboard Cite

In-vitro apatite layer formation on the surface of a newly developed glass reinforced hydroxyapatite composite was characterized using X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) equipped with energy dispersive X-ray analysis (EDXA). After I week soaking in an acellular simulated body fluid the composite surface was entirely covered by a Ca, P-layer, suggesting a bioactive behaviour. XPS binding energy results revealed that this surface layer was a carbonated and non-stoichiometric apatite with Ca/P ratio of 1.3. This apatite layer was composed of very fine needle-like crystallites. Comparative studies on a commercially available hydroxyapatite showed that a similar apatite layer was also formed on its surface.

show abstract

Section: Introductionmentioning

confidence: 99%

In vitro calcium phosphate formation on SiO2-Na2O-CaO-P2O5 glass reinforced hydroxyapatite composite: a study by XPS analysis

Santos

Jha²,

Monteiro

1996

J Mater Sci: Mater Med

View full text Add to dashboard Cite

show abstract

“…As phosphorous is one of the main impurities in molten steel, the tight control of P content is critical to produce high quality steels including line pipe steel . P 2 O 5 is also an essential constituent of calcium phosphate glasses which have been widely used thanks to their high thermal expansion coefficient, low viscosity, UV transmission, electrical conductivity, and biocompatibility . Unfortunately, in spite of their importance, thermodynamic data on solid and liquid P 2 O 5 are very scarce in the literature.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 P 2 O 5 is also an essential constituent of calcium phosphate glasses which have been widely used thanks to their high thermal expansion coefficient, low viscosity, UV transmission, electrical conductivity, and biocompatibility. [3][4][5][6][7] Unfortunately, in spite of their importance, thermodynamic data on solid and liquid P 2 O 5 are very scarce in the literature.…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic Assessment of P₂O₅

Jung

Hudon

2012

J. Am. Ceram. Soc.

View full text Add to dashboard Cite

All the thermodynamic property data and phase diagrams related to solid and liquid P2O5 were critically evaluated and optimized to obtain the best set of Gibbs energies for all phases. Confusion in literature data due to the very sluggish nature of the reactions involving P2O5 was resolved. The Gibbs energies of O‐ and O′‐P2O5 were evaluated for the first time based on the phase stability against gas. The Gibbs energy of liquid H‐P2O5, liquid O‐P2O5, and liquid O′‐P2O5 were also properly evaluated for the first time based on the metastable and stable vapor pressures. The calculated triple points of H‐P2O5, O‐P2O5, and O′‐P2O5 are 420°C and 4.600 bar, 575°C and 0.805 bar, and 580°C and 0.774 bar, respectively. The calculated polymorphic transition point between O‐P2O5 and O′‐P2O5 is located at 65°C and 0.001 bar.

show abstract

“…Hydroxyapatite (HA) has been often designated as an osteoconductive material [1]. However, one common problem of ceramics, intended for load-bearing clinical applica-tions, is their poor mechanical properties, such as low bending strength and brittle nature combined with low values of fracture toughness [2,3]. On the basis of these findings, adaptative interface functionalities were set as a target, keeping in mind that they should not compromise either chemical or physical bulk properties, and must simultaneously improve the tissue integration.…”

Section: Introductionmentioning

confidence: 99%

Incorporation of proteins and enzymes at different stages of the preparation of calcium phosphate coatings on a degradable substrate by a biomimetic methodology

Azevedo

Leonor

Alves

et al. 2005

Materials Science and Engineering: C

View full text Add to dashboard Cite

In this work, the possibility of incorporating proteins into calcium phosphate (Ca-P) coatings, prepared on the surface of starch polymeric biomaterials by means of a biomimetic route, was investigated. The morphology, chemical composition and crystallinity of CaP coatings was assessed and related to the incorporation of the studied biomolecules. For that, bovine serum albumin (BSA) and aamylase were added in concentrations of 1 mg/ml to simulated body fluid (SBF) solutions, being both added at the nucleation or growth stages of the biomimetic coating process. A biodegradable blend of corn starch/ethylene vinyl alcohol (SEVA-C) was used as substrate and bioactive glass (45S5 BioglassR) was used as the nucleating agent. The obtained CaP coatings were characterised by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy using an attenuated reflectance device (FTIR-ATR) and thin-film X-ray diffraction (TF-XRD). Additionally, to evaluate the activity of the incorporated enzyme and the stability of the CaP films, coated samples were immersed in an SBF solution for different periods of time. The enzyme activity was measured and the morphology of the coating examined by SEM. The results obtained showed that the presence of protein molecules, at the nucleation or growth stages, lead to the formation of a dense CaP film presenting different morphologies that were different of the selected coating conditions. FTIR-ATR analysis detected the presence of carbonate and phosphate groups on the CaP layer, indicating the formation of a coating similar to the mineral component of vertebrates bone tissue. When proteins were added, amide I and amide II bands, characteristic groups of protein molecules, were also detected, revealing the efficient incorporation of these biomolecules into the CaP coatings. CaP coatings, with a-amylase incorporated at the nucleation stage, showed no degradation of the film after incubation in SBF for 28 days. The release of increasing concentration of reducing sugars with degradation time revealed that a-amylase was efficiently incorporated in the coating remaining active throughout the coating preparation. This can be a strategy that will allow, in addition of conferring osteoconductive properties to biodegradable polymers, also simultaneously tailoring their degradation kinetics.

show abstract

Calcium phosphate glasses and glass-ceramics for medical applications

Cited by 20 publications

References 7 publications

In vitro calcium phosphate formation on SiO2-Na2O-CaO-P2O5 glass reinforced hydroxyapatite composite: a study by XPS analysis

In vitro calcium phosphate formation on SiO2-Na2O-CaO-P2O5 glass reinforced hydroxyapatite composite: a study by XPS analysis

Thermodynamic Assessment of P₂O₅

Incorporation of proteins and enzymes at different stages of the preparation of calcium phosphate coatings on a degradable substrate by a biomimetic methodology

Contact Info

Product

Resources

About

Calcium phosphate glasses and glass-ceramics for medical applications

Cited by 20 publications

References 7 publications

In vitro calcium phosphate formation on SiO2-Na2O-CaO-P2O5 glass reinforced hydroxyapatite composite: a study by XPS analysis

In vitro calcium phosphate formation on SiO2-Na2O-CaO-P2O5 glass reinforced hydroxyapatite composite: a study by XPS analysis

Thermodynamic Assessment of P2O5

Incorporation of proteins and enzymes at different stages of the preparation of calcium phosphate coatings on a degradable substrate by a biomimetic methodology

Contact Info

Product

Resources

About

Thermodynamic Assessment of P₂O₅