Calcium Pyrophosphate Dihydrate Crystal Deposition Disease

Abstract

Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease is characterized by the accumulation of pyrophosphate dihydrate crystals in articular and periarticular tissues. Various terms have been utilized to describe this arthropathy, which has led to some confusion. CPPD crystal deposition disease is among many conditions that may result in crystal deposition within cartilage. Chondrocalcinosis is a pathologic and radiographic term denoting calcification of cartilage within joints including both hyaline articular cartilage and fibrocartilage. Pseudogout is a clinical term applied to an acute inflammatory process in a joint(s) mimicking a gout attack. Pseudogout is just one of the multiple clinical presentations for CPPD crystal deposition disease. Pyrophosphate arthropathy is a term that has been used to describe the peculiar pattern of joint destruction associated with CPPD crystal deposition disease. This article reviews the protean manifestations of CPPD crystal deposition disease with emphasis on diagnostic imaging.

Radiological identification and analysis of soft tissue musculoskeletal calcifications

“…However, when there is chronic CPPD arthropathy, it resembles osteoarthritis but harbours distinctive features, such as small or absent osteophytes, well-defined subchondral sclerosis and large subchondral cysts. Its distribution is also different from osteoarthritis, with more frequent involvement of the patellofemoral joint; the radiocarpal joint associated with a scapholunate advance collapse (SLAC) appearance [ 24 , 25 ]; the second and third metacarpophalangeal joints; and the glenohumeral joint (Fig. 10 ).…”

Pseudogout After Total Knee Arthroplasty Meeting Minor Criteria for Infection Treated by Polyethylene Exchange

“…1 The acute manifestation of this condition is referred to as pseudogout due to a clinical presentation similar to that of an acute episode of urate arthropathy known as a gout attack. 2 Larger joints are frequently affected by CPPD with the knees, hips, and shoulders being the most common locations. 2 CPPD has an estimated prevalence of 4% to 7% of the population with a predisposition towards elderly patients.…”

“…2 Larger joints are frequently affected by CPPD with the knees, hips, and shoulders being the most common locations. 2 CPPD has an estimated prevalence of 4% to 7% of the population with a predisposition towards elderly patients. 3,4 The clinical presentation of periprosthetic crystalline arthropathy, which includes both gout and pseudogout, is similar to PJI with underlying symptoms consisting of erythema, swelling, and pain in the affected joint.…”

Pseudotumoural soft tissue lesions of the hand and wrist: a pictorial review

“…17). Clinical and radiographic findings of tophaceous gout or pseudogout are usually diagnostic [40–42]. Calcification is more frequently seen in pseudogout.…”