Calcium Sulfate– And Calcium Phosphate–based Bone Substitutes

Tay, Bobby; Patel, Vikas V.; Bradford, David S.

doi:10.1016/s0030-5898(05)70114-0

Cited by 202 publications

(121 citation statements)

References 26 publications

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“…First, ICPC binds with the bone tunnel after hardening and improves the pull-out force through new bone and hardened CPC. 22 Second, ICPC may prevent graft-tunnel interface micromotion 23 and prevent the synovial fluid with increased levels of cytokines from entering into the interface. Third, if the slow degradation of ICPC releases BMP slowly, it could induce more targeted cells to differentiate along the osteoblast linage and form more new bone.…”

Section: Comparative In Vivo Study Of Injectable Biomaterialsmentioning

confidence: 99%

Comparative in vivo study of injectable biomaterials combined with BMP for enhancing tendon graft osteointegration for anterior cruciate ligament reconstruction

Pan

Wei

Zhou

et al. 2011

Journal Orthopaedic Research

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This study was to compare effect of osteointegration of grafted tendon in bone tunnels between injected calcium phosphate cement (ICPC) and injected fibrin sealant (IFS) combined with bone morphogenetic protein (BMP) after anterior cruciate ligament (ACL) reconstruction. ACL reconstruction was performed bilaterally in 51 rabbits. ICPC-BMP composite was injected into one knee, with the contralateral knee IFS-BMP composite. The rabbits were killed at postoperative weeks 2, 6, and 12 for testing. Histological observations showed the ICPC composite gradually increased the new bone formation during the whole healing process, while the IFS composite had a burst effect on enhancing the healing of tendon-to-bone at 2 and 6 weeks. By 12 weeks, there was more new cartilage and new bone in the interface in the ICPC-bBMP group. Micro-CT showed that the values of BMD in the ICPC-bBMP group were lower than those in the IFSbBMP group at 6 weeks, while the values in the ICPC-bBMP group were higher than those in the IFS-bBMP group at 12 weeks (p > 0.05). Fluorescent labels showed that the rate of new bone formation of IFS-BMP composite was significantly higher than that of ICPC composite at 6 weeks (3.45 AE 0.62 mm/day vs. 2.93 AE 0.51 mm/day), but the rate was decreased compared with ICPC composite at 12 weeks (2.58 AE 0.72 mm/day vs. 3.05 AE 0.68 mm/day; p < 0.05). Biomechanically, the ultimate failure load in the ICPC-BMP group was always higher than that in the IFS-BMP group. It is evident that the ICPC composite achieved a more prolonged osteogenic effect than that by IFS composite. ß

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Section: Comparative In Vivo Study Of Injectable Biomaterialsmentioning

confidence: 99%

Comparative in vivo study of injectable biomaterials combined with BMP for enhancing tendon graft osteointegration for anterior cruciate ligament reconstruction

Pan

Wei

Zhou

et al. 2011

Journal Orthopaedic Research

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“…The product has been approved by the FDA and is CE marked. It can be used alone or in combination with other naturally occurring materials to ll bone voids or gaps (Pecora et al 1998, Debes et al 1999, Tay et al 1999, Wilkins et al 1999. The effectiveness of calcium sulfate as a vehicle for delivery of local antibiotic treatment has also been shown (Petersen et al 1999, Turner et al 2000.…”

mentioning

confidence: 99%

No effect of Osteoset ® , a bone graft substitute, on bone healing in humans: A prospective randomized double-blind study

Petruskevicius

Nielsen

Kaalund

et al. 2002

Acta Orthopaedica Scandinavica

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“…Calcium Sulfate is one of the synthetic biomaterials with a long history of clinical use as a graft substitute for bone regeneration (Peltier et al, 1957;Tay et al, 1999). The dihydrated form of calcium sulfate, also called "gypsum", presents a crystalline structure that is not very uniform, and is currently used as a raw material in a calcination process that results in hemi-hydrated calcium sulfate (CaSO4.½ H2O), also called "Plaster of Paris" (Peltier et al, 1957).…”

Section: Bioceramicsmentioning

confidence: 99%