Calcium Supplementation and Bone Mineral Density in Adolescent Girls

Lloyd, Tom; Andon, M B; Rollings, Nan; Martel, Julie; Landis, J. Richard; Demers, Laurence M.; Eggli, Douglas F.; Kieselhorst, Kessey; Kulin, Howard E.

doi:10.1001/jama.1993.03510070063037

Cited by 384 publications

(95 citation statements)

References 33 publications

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“…The supplemented group had an average daily calcium intake of 1,612 mg/d (1,000 mg/d calcium citrate) compared with 908 mg/d in the placebo group after a 3-year-supplementation period. A shorter trial of 18 months also found significant changes in lumbar spine aBMD in supplemented peripubertal girls with an average daily calcium intake of 1,300 mg/d compared with 960 mg/d in the control group [27]. In the present study, the supplemented group achieved positive skeletal responses with an average calcium intake of 1,563 mg/d compared with the placebo group of 786 mg/d.…”

Section: Discussionsupporting

confidence: 64%

Calcium and vitamin-D supplementation on bone structural properties in peripubertal female identical twins: a randomised controlled trial

Greene

Naughton

2010

Osteoporos Int

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Section: Discussionsupporting

confidence: 64%

Calcium and vitamin-D supplementation on bone structural properties in peripubertal female identical twins: a randomised controlled trial

Greene

Naughton

2010

Osteoporos Int

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“…The result in boys may be a parallel to what has been found in intervention studies. In general, calcium intervention studies where the calcium intake was increased by a supplement have shown an increase in BMC or BMD during the intervention [18][19][20][21], but this effect disappeared after the calcium supplementation was stopped [22,23]. Another characteristic is that the increase in bone mineral appears early during the intervention with little further effect later on [18,20].…”

Section: Discussionmentioning

confidence: 99%

“…In two of them an association was found: one with prepubertal children [16] and one with young children below 18 months of age [17]. Calcium intervention studies where calcium intake was increased by a supplement have generally shown a positive effect on bone mineralization during the intervention [18][19][20][21], but this effect disappeared after the calcium supplementation was stopped [22,23]. To our knowledge no studies have examined the relation between change in dietary calcium intake during the study period and bone growth.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Calcium Intake and Physical Activity on Bone Mineral Content and Bone Size in Healthy Children and Adolescents

Mølgaard¹,

Thomsen

Michaelsen³

2001

Osteoporosis International

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Studies of determinants of bone mineralization during growth are relevant to the attempt to increase peak bone mass. The aim of this study was to examine how calcium intake and physical activity influence bone size (bone area, BA), accretion in BA, whole body bone mineral content (BMC) and accretion in BMC. BA and BMC were examined by dual-energy X-ray absorptiometry (Hologic 1000/W) in healthy girls (n = 192) and boys (n = 140) aged 5-19 years at baseline and 1 year later. Calcium intake was assessed three times by a food frequency questionnaire and physical activity three times by a 24 h recall questionnaire. The influence of calcium intake and physical activity was examined by multiple regression. BA was size-adjusted by including height and weight in all analyses, and BMC was size-adjusted by including BA, height and weight in all analyses. Size-adjusted average BA was associated neither with average calcium intake nor with average physical activity. Size-adjusted accretion in BA was borderline associated with the average calcium intake in boys only (p = 0.07). Size-adjusted average BMC was positively associated with average calcium intake (p) = 0.03 girls; p = 0.07 boys) and borderline associated with average physical activity level in boys (p = 0.07) but not girls (p = 0.7). Size-adjusted accretion in BMC was significantly associated neither with average calcium intake nor with average physical activity level, but was associated with change in calcium intake over the 1 year observation period in boys (p = 0.03) but not girls (p = 0.9). In conclusion, we found that size-adjusted BMC in school-aged children was positively associated with average calcium intake. Size-adjusted accretion in BMC was positively associated with change in dietary calcium intake in boys only. To what degree this is caused by a reduction in remodeling space is unknown.

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“…During growth chronic calcium deficiency causes rickets [6,7]. Calcium supplementation in both pre-and post-pubertal healthy children leads to increased bone mass [44][45][46][47]. In adolescents the higher the calcium intake, the greater the calcium retention, with the highest retention occurring just after menarche [48,49].…”

Section: Skeletal Pathophysiologymentioning

confidence: 99%

Effects of Calcium and Vitamin D Insufficiency on the Skeleton

Peacock

1998

Osteoporos Int

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Calcium Supplementation and Bone Mineral Density in Adolescent Girls

Cited by 384 publications

References 33 publications

Calcium and vitamin-D supplementation on bone structural properties in peripubertal female identical twins: a randomised controlled trial

Calcium and vitamin-D supplementation on bone structural properties in peripubertal female identical twins: a randomised controlled trial

The Influence of Calcium Intake and Physical Activity on Bone Mineral Content and Bone Size in Healthy Children and Adolescents

Effects of Calcium and Vitamin D Insufficiency on the Skeleton

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