Calibration of blood flow measurement with spectral domain optical coherence tomography

Wehbe, Hassan; Ruggeri, Marco; Jiao, Shuliang; Gregori, Giovanni; Puliafito, Carmen A.; Zhao, Weizhao

doi:10.1364/biomed.2008.bmd75

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…Measurement of flow in branch retinal vessels in vivo has recently been accomplished using Doppler Fourier domain OCT (FD-OCT) 20,21. Phantom flow measurements showed22 that the difference between the measured flow and actual flow is less than 10%. However, sequentially imaging each retinal blood vessel is time-consuming and not a practical way of measuring the total retinal perfusion in a clinical setting.…”

Section: Introductionmentioning

confidence: 99%

Retinal blood flow measurement by circumpapillary Fourier domain Doppler optical coherence tomography

et al. 2008

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We present in vivo human total retinal blood flow measurements using Doppler Fourier domain optical coherence tomography (OCT). The scan pattern consisted of two concentric circles around the optic nerve head, transecting all retinal branch arteries and veins. The relative positions of each blood vessel in the two OCT conic cross sections were measured and used to determine the angle between the OCT beam and the vessel. The measured angle and the Doppler shift profile were used to compute blood flow in the blood vessel. The flows in the branch veins was summed to give the total retinal blood flow at one time point. Each measurement of total retinal blood flow was completed within 2 s and averaged. The total retinal venous flow was measured in one eye each of two volunteers. The results were 52.90±2.75 and 45.23±3.18 μl/min, respectively. Volumetric flow rate positively correlated with vessel diameter. This new technique may be useful in the diagnosis and treatment of optic nerve and retinal diseases that are associated with poor blood flow, such as glaucoma and diabetic retinopathy.

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Section: Introductionmentioning

confidence: 99%

Retinal blood flow measurement by circumpapillary Fourier domain Doppler optical coherence tomography

et al. 2008

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“…Recently, in vivo measurements of volume retinal blood flow were reported by sequentially scanning each of retinal branch vessels that surrounded the optic nerve head utilizing Doppler Fourier Domain OCT (FD-OCT) [21-23]. Phantom flow measurement [24] showed the flow difference was less than 10% between the measured flow and flow setting. Through 3D circular scanning, Wehbe and co-workers showed blood flow measurement in two retinal vessels [25].…”

Section: Introductionmentioning

confidence: 99%

Retinal blood flow detection in diabetic patients by Doppler Fourier domain optical coherence tomography

Wang¹,

Fawzi²,

Tan³

et al. 2009

Opt. Express

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We present human retinal blood flow investigation for diabetic patients using Doppler Fourier domain optical coherence tomography (FD-OCT). The scanning pattern consisted of two concentric circles around the optic nerve head. The blood flow in one patient with diabetes and no retinpathy and another patient with treated proliferative diabetic retinopathy were measured. The patient without retinopathy showed a total blood flow value at the lower level of the normal range. The flow distribution between superior and inferior retina was balanced. The patient with diabetic retinopathy had a flow value lower than the normal people. Our study shows that Doppler FD-OCT can be used to evaluate the total retinal blood flow in patients with retinal diseases.

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“…24,25 Phantom flow measurements identified the difference between measured flow and actual flow as less than 10%. 26 A pilot study using Doppler OCT identified a significant correlation between reduced retinal blood flow and visual field loss in glaucoma. 27 While there is general consensus that ocular blood flow is reduced in glaucoma, the precise relationship among visual field loss, blood flow, and structural damage remains controversial.…”

mentioning

confidence: 99%

Relationship among Visual Field, Blood Flow, and Neural Structure Measurements in Glaucoma

Hwang

Konduru

Zhang

et al. 2012

Invest. Ophthalmol. Vis. Sci.

106

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Calibration of blood flow measurement with spectral domain optical coherence tomography

Cited by 4 publications

References 4 publications

Retinal blood flow measurement by circumpapillary Fourier domain Doppler optical coherence tomography

Retinal blood flow measurement by circumpapillary Fourier domain Doppler optical coherence tomography

Retinal blood flow detection in diabetic patients by Doppler Fourier domain optical coherence tomography

Relationship among Visual Field, Blood Flow, and Neural Structure Measurements in Glaucoma

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