Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients

Abstract

BackgroundGenetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain-10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients.MethodsOverall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study. All the subjects were genotyped for SNP-43 and -63 of calpain-10 gene and G276T and T45G frequencies of the adiponectin gene. The clinical characteristics and measure of glucose metabolism were compared within these genotypes.ResultsAmong calpain-10 polymorphisms, SNP-63 T/T were more frequent in diabetes patients, and single SNP-63 increases the susceptibility to type 2 diabetes. However, SNP-43 in calpain-10 and T45G and intron G276T in adiponectin gene were not significantly associated with diabetes, insulin resistance, nor insulin secretion.ConclusionVariations in calpain-10, SNP-63 seems to increase the susceptibility to type 2 diabetes in Koreans while SNP-43 and adiponectin SNP-45, -276 are not associated with impaired glucose metabolism.

Meta-analysis of the association between adiponectin SNP 45, SNP 276, and type 2 diabetes mellitus

“…Also, other previous meta-analyses [ 7 , 64 ] showed that the polymorphism of this site was not associated with T2DM. Secondly, no correlation was established between the rs2241766 polymorphism of the ADIPOQ gene and T2DM in the East Asian population, which was consistent with the results of the study by Kaitsai et al [ 6 , 32 , 50 , 65 ]. Conversely, rs2241766 polymorphism is a potential factor of T2DM as demonstrated previously [ 66 – 68 ].…”

“…Some studies have shown that rs2241766 [ 23 , 27 , 30 , 39 , 43 ] and rs1501299 [ 9 , 28 – 30 ] polymorphisms are related to T2DM, while others have a contrasting viewpoint: rs2241766 [ 4 , 9 , 16 , 17 , 26 , 28 , 31 , 34 , 46 – 48 , 50 , 51 , 53 ] and rs1501299 [ 6 , 16 , 17 , 23 , 26 , 27 , 31 , 34 , 49 , 51 – 53 ]. These discrepancies in the results might be attributed to the small size of the population in a single study and the background or ethnic differences of the random samples.…”

Association of Candidate Gene Polymorphism with Metabolic Syndrome among Mongolian Subjects: A Case-Control Study

“…However, the mechanism of whether the + 45T > G polymorphism influences the hypertension susceptibility through the low levels of plasma adiponectin warrants further study. Another study, inversely, did not detect such effects or provided contradictory results concerning the polymorphic sites that are involved with an alteration in blood lipids [ 33 ] and glucose [ 34 ]. Nevertheless, it should be noted that several recent genome-wide association studies (GWAS) have been carried out on MetS components: obesity, dyslipidemia, high BP and T2D individually in several populations, most of which were conducted in people of European descent.…”

Silencing LncRNA PVT1 Reverses High Glucose-Induced Regulation of the High Expression of PVT1 in HRMECs by Targeting miR-128-3p

“…It can be divided into type 1 diabetes in which the human body cannot synthesize and secrete insulin; type 2 diabetes in which insulin resistance is the mainstay; and other types such as gestational diabetes [2][3][4]. Different types of diabetes have different causes, such as family inheritance, environmental influence, obesity, and excessive sugar intake [5,6]. Diabetic retinopathy (DR) is the most common microvascular complication of diabetes [7,8].…”