Cambios estructurales y funcionales del hipocampo en pacientes con esclerosis múltiple y su relación con procesos de memoria

Cruz-Gómez, Álvaro Javier; Belenguer-Benavides, A; Martínez-Bronchal, Beatriz; Fittipaldi-Márquez, M Sol; Forn, Cristina

doi:10.33588/rn.6201.2015216

Cited by 5 publications

(1 citation statement)

References 28 publications

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“…This cognitive dysfunction is a manifestation of axonal injury 11,12 that is widely distributed throughout the brain and manifests as neuropsychological deficits, in attention, memory, learning, executive function, and processing speed. Using magnetic resonance imaging (MRI) measures, Filippi et al 13 noted that cognitive impairment in MS is related to atrophy in the gray matter damage and Cruz-Gómez et al 14 suggest that low performance in episodic and declarative memory tasks is associated with reduced functional connectivity of the left hippocampus. Several studies [15][16][17][18] show that cognitive deficits are present in the early stages of the MS, and the impairment include alterations in processes such as attention, memory, executive function, and processing speed.…”

Section: Introductionmentioning

confidence: 99%

Neuropsychological differences between types of multiple sclerosis: relapsing remitting versus primary progressive

Álvarez

Parra-Bolaños

Bernabéu-Brotóns

et al. 2020

RMN

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Background: Multiple sclerosis (MS) is a neurodegenerative disease whose clinical deterioration is observed at a physical, cognitive, and socio-emotional level, affecting the quality of life of the patient. Several scientific studies show early cognitive alterations in MS and profiles of different cognitive affectation according to the clinical form of the disease. Objective: The objective of the study was to analyze the existence of significant differences between relapsing remitting MS (RRMS) and primary progressive MS (PPMS) in neuropsychological processes such as attention, memory, language, visuoperception, executive function, and processing speed. Methods: The sample consisted of 20 patients with MS with chronological ages between 20 and 50 years of both sexes belonging to the Psique de Medellín Foundation, who were administered the paced auditory serial addition test and the digit-symbol test to assess attention, the complex figure of Rey to evaluate memory, the Boston test, and verbal fluency to assess language, complex figure of Rey copy for visuoperception, Wisconsin to assess executive function, and trail making test to measure processing speed. A descriptive, inferential, and transversal design was used. Results: There are no significant differences between the scores of patients with RRMS and PPMS in any assessed neuropsychological process. Conclusion: Knowing the neuropsychological profile of MS in early stages can be useful as an indicator of prognosis and to suggest therapeutic and follow-up strategies in patients with RRMS and PPMS.

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Section: Introductionmentioning

confidence: 99%

Neuropsychological differences between types of multiple sclerosis: relapsing remitting versus primary progressive

Álvarez

Parra-Bolaños

Bernabéu-Brotóns

et al. 2020

RMN

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Altered hippocampal GABA and glutamate levels and uncoupling from functional connectivity in multiple sclerosis

et al. 2018

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There is growing evidence for dysfunctional glutamatergic excitation and/or gamma-aminobutyric acid (GABA)ergic inhibition in patients with multiple sclerosis (MS). Cognitive impairment may occur during the early stages of MS and hippocampal abnormalities have been suggested as biomarkers. However, researchers have not clearly determined whether changes in hippocampal GABA and glutamate (Glu) levels are associated with cognitive impairment and aberrant neural activity in patients with MS. We used magnetic resonance spectroscopy to measure GABA+ and Glu levels in the left hippocampal region of 29 patients with relapsing-remitting MS and 29 healthy controls (HCs). Resting-state functional connectivity (FC) with the hippocampus was also examined. Compared to HCs, patients exhibited significantly lower GABA+ and Glu levels, which were associated with verbal and visuospatial memory deficits, respectively. Patients also showed decreased FC strengths between the hippocampus and several cortical regions, which are located within the default mode network. Moreover, hippocampal GABA+ levels and Glu/GABA+ ratios correlated with the FC strengths in HCs but not in patients with MS. This study describes a novel method for investigating the complex relationships among excitatory/inhibitory neurotransmitters, brain connectivity and cognition in health and disease. Strategies that modulate Glu and GABA neurotransmission may represent new therapeutic treatments for patients with MS.

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Microstructural Changes in Patients With Parkinson's Disease Comorbid With REM Sleep Behaviour Disorder and Depressive Symptoms

et al. 2018

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The diagnosis of Parkinson's disease (PD) is currently anchored on clinical motor symptoms, which appear more than 20 years after initiation of the neurotoxicity. Extra-nigral involvement in the onset of PD with probable nonmotor manifestations before the development of motor signs, lead us to the preclinical (asymptomatic) or prodromal stages of the disease (various nonmotor or subtle motor signs). REM sleep behavior disorder (RBD) and depression are established prodromal clinical markers of PD and predict worse motor and cognitive outcomes. Nevertheless, taken by themselves, these markers are not yet claimed to be practical in identifying high-risk individuals. Combining promising markers may be helpful in a reliable diagnosis of early PD. Therefore, we aimed to detect neural correlates of RBD and depression in 93 treatment-naïve and non-demented early PD by means of diffusion MRI connectometry. Comparing four groups of PD patients with or without comorbid RBD and/or depressive symptoms with each other and with 31 healthy controls, we found that these two non-motor symptoms are associated with lower connectivity in several white matter tracts including the cerebellar peduncles, corpus callosum and long association fibers such as cingulum, fornix, and inferior longitudinal fasciculus. For the first time, we were able to detect the involvement of short association fibers (U-fibers) in PD neurodegenerative process. Longitudinal studies on larger sample groups are needed to further investigate the reported associations.

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Cambios estructurales y funcionales del hipocampo en pacientes con esclerosis múltiple y su relación con procesos de memoria

Abstract: Cambios estructurales y funcionales del hipocampo en pacientes con esclerosis múltiple y su relación con procesos de memoria.

Cited by 5 publications

References 28 publications

Neuropsychological differences between types of multiple sclerosis: relapsing remitting versus primary progressive

Neuropsychological differences between types of multiple sclerosis: relapsing remitting versus primary progressive

Altered hippocampal GABA and glutamate levels and uncoupling from functional connectivity in multiple sclerosis

Microstructural Changes in Patients With Parkinson's Disease Comorbid With REM Sleep Behaviour Disorder and Depressive Symptoms

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