cAMP Is a Promising Regulatory Molecule for Plant Adaptation to Heat Stress

Abstract

With gradual warming or increased frequency and magnitude of high temperature, heat stress adversely affects plant growth and eventually reduces plant productivity and quality. Plants have evolved complex mechanisms to sense and respond to heat stress which are crucial to avoiding cell damage and maintaining cellular homeostasis. Recently, 33″,55″-cyclic adenosine monophosphate (cAMP) has been proved to be an important signaling molecule participating in plant adaptation to heat stress by affecting multi-level regulatory networks. Significant progress has been made on many fronts of cAMP research, particularly in understanding the downstream signaling events that culminate in the activation of stress-responsive genes, mRNA translation initiation, vesicle trafficking, the ubiquitin-proteasome system, autophagy, HSPs-assisted protein processing, and cellular ion homeostasis to prevent heat-related damage and to preserve cellular and metabolic functions. In this present review, we summarize recent works on the genetic and molecular mechanisms of cAMP in plant response to heat stress which could be useful in finding thermotolerant key genes to develop heat stress-resistant varieties and that have the potential for utilizing cAMP as a chemical regulator to improve plant thermotolerance. New directions for future studies on cAMP are discussed.

Combined transcriptomic and metabolomic analyses of high temperature stress response of quinoa seedlings

“…APT activity in recycling nucleoside in the salvage pathway also enables it to regulate the flux of the nucleotide degradation pathway [ 40 ]. AMP plays an important role in mediating stress by altering plant hormone homeostasis and energy metabolites [ 41 ]. Additionally, alterations in adenine at the cellular level can trigger tolerance and promote growth [ 42 ], and purine recycling pathways can play the role of cellular signaling molecules in regulating plant responses to abiotic stresses [ 43 ].…”

Coupling thermotolerance and high production of recombinant protein by CYR1N1546K mutation via cAMP signaling cascades

“…Additionally, genes associated with Golgi vesicle transport and resistance to ROS were commonly upregulated in these conditions (Supplementary Data 4). Previous researches demonstrated that the addition of cAMP can enhance the expression of genes involved in vesicle transport at high temperatures 27 and boost cellular resistance to ROS 28 . Therefore, it is possible that YKL069W mediate the pulsatile increase in cAMP levels, leading to the upregulation of vesicle transport genes and anti-ROS genes.…”

The hot science in rice research: How rice plants cope with heat stress

“…NO bursting at the apex of shoots under heat stress conditions triggers whole‐plant cellular responses to high temperatures and S‐nitrosylates a trihelix transcription factor GT‐1, thus enhancing its binding to NO‐responsive elements in the HSFA2 promoter and downstream gene expression in Arabidopsis (He et al, 2022). As a signalling molecule, 3ʹ,5ʹ‐cyclic adenosine monophosphate (cAMP) affects multiple levels of regulatory networks in plants to combat heat stress (Liang et al, 2022). However, how these two signalling molecules function in rice is unknown.…”