Can brain-derived neurotrophic factor (BDNF) be an indicator of effective rehabilitation interventions in schizophrenia?

Markiewicz, Renata; Kozioł, Małgorzata; Olajossy, Marcin; Masiak, Jolanta

doi:10.12740/pp/onlinefirst/76040

Cited by 21 publications

(23 citation statements)

References 79 publications

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“…On the other hand, another tACS study did not find any differences between the magnitude of responsiveness to tACS and BDNF different alleles (Guerra et al, 2020 ). In the same vein, BDNF has been theorized to be linked with greater magnitudes of EEG responses to NFB (Markiewicz et al, 2017 ), which was later experimentally tested by measuring the level of concentration of BDNF before and after multi-session NFB intervention (Lee et al, 2019 ; Markiewicz and Dobrowolska, 2020 ). While one study found a remarkable upregulation of BDNF in the post-NFB period compared to the pre-NFB period (Markiewicz and Dobrowolska, 2020 ), the second study did not find any significant differences between the pre-NFB period and the post-NFB period (Lee et al, 2019 ).…”

Section: Mechanisms Of Tacs and Nfbmentioning

confidence: 99%

Effects of Transcranial Alternating Current Stimulation and Neurofeedback on Alpha (EEG) Dynamics: A Review

Orendáčová

Kvašňák

2021

Front. Hum. Neurosci.

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Transcranial alternating current stimulation (tACS) and neurofeedback (NFB) are two different types of non-invasive neuromodulation techniques, which can modulate brain activity and improve brain functioning. In this review, we compared the current state of knowledge related to the mechanisms of tACS and NFB and their effects on electroencephalogram (EEG) activity (online period/stimulation period) and on aftereffects (offline period/post/stimulation period), including the duration of their persistence and potential behavioral benefits. Since alpha bandwidth has been broadly studied in NFB and in tACS research, the studies of NFB and tACS in modulating alpha bandwidth were selected for comparing the online and offline effects of these two neuromodulation techniques. The factors responsible for variability in the responsiveness of the modulated EEG activity by tACS and NFB were analyzed and compared too. Based on the current literature related to tACS and NFB, it can be concluded that tACS and NFB differ a lot in the mechanisms responsible for their effects on an online EEG activity but they possibly share the common universal mechanisms responsible for the induction of aftereffects in the targeted stimulated EEG band, namely Hebbian and homeostatic plasticity. Many studies of both neuromodulation techniques report the aftereffects connected to the behavioral benefits. The duration of persistence of aftereffects for NFB and tACS is comparable. In relation to the factors influencing responsiveness to tACS and NFB, significantly more types of factors were analyzed in the NFB studies compared to the tACS studies. Several common factors for both tACS and NFB have been already investigated. Based on these outcomes, we propose several new research directions regarding tACS and NFB.

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Section: Mechanisms Of Tacs and Nfbmentioning

confidence: 99%

Effects of Transcranial Alternating Current Stimulation and Neurofeedback on Alpha (EEG) Dynamics: A Review

Orendáčová

Kvašňák

2021

Front. Hum. Neurosci.

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“…BDNF deficiency is observed in neurons that are rich in neurofibrillary tangles (NFTs) in AD, while disorders in its synthesis are associated with mutations of α-synuclein protein (ASN) in the hereditary form of early onset PD [86,87,88]. A decrease in BDNF concentration is also observed in schizophrenia, which suggests the involvement of this factor in the disease etiology [89]. It was found that synapse degeneration is the main manifestation of pathology observed in various forms of dementia, especially in AD [90].…”

Section: Neuronal Communicationmentioning

confidence: 99%

Perineuronal Nets and Their Role in Synaptic Homeostasis

Bosiacki

Gąssowska-Dobrowolska

Kojder

et al. 2019

IJMS

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Extracellular matrix (ECM) molecules that are released by neurons and glial cells form perineuronal nets (PNNs) and modulate many neuronal and glial functions. PNNs, whose structure is still not known in detail, surround cell bodies and dendrites, which leaves free space for synapses to come into contact. A reduction in the expression of many neuronal ECM components adversely affects processes that are associated with synaptic plasticity, learning, and memory. At the same time, increased ECM activity, e.g., as a result of astrogliosis following brain damage or in neuroinflammation, can also have harmful consequences. The therapeutic use of enzymes to attenuate elevated neuronal ECM expression after injury or in Alzheimer’s disease has proven to be beneficial by promoting axon growth and increasing synaptic plasticity. Yet, severe impairment of ECM function can also lead to neurodegeneration. Thus, it appears that to ensure healthy neuronal function a delicate balance of ECM components must be maintained. In this paper we review the structure of PNNs and their components, such as hyaluronan, proteoglycans, core proteins, chondroitin sulphate proteoglycans, tenascins, and Hapln proteins. We also characterize the role of ECM in the functioning of the blood-brain barrier, neuronal communication, as well as the participation of PNNs in synaptic plasticity and some clinical aspects of perineuronal net impairment. Furthermore, we discuss the participation of PNNs in brain signaling. Understanding the molecular foundations of the ways that PNNs participate in brain signaling and synaptic plasticity, as well as how they change in physiological and pathological conditions, may help in the development of new therapies for many degenerative and inflammatory diseases of the brain.

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“…Under the influence of these processes, neurotransmitters are produced, which enable the remodeling of the synaptic network and the formation of new connections. Synaptic reorganization occurs when changes in action potential are induced by effective stimulation [29][30][31][32], such as GSR BF training.…”

Section: Introductionmentioning

confidence: 99%

Reinforcement of Self-Regulated Brain Activity in Schizophrenia Patients Undergoing Rehabilitation

Markiewicz

Dobrowolska

2021

BioMed Research International

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The experiment was aimed to compare the effects of different forms of rehabilitation applied in patients with schizophrenia. Verification of the obtained results was based on the analysis of the level of cognitive and social functioning of the subjects. For this purpose, the following clinical tools were used: Positive and Negative Syndrome Scale (PANSS), Beck Cognitive Insight Scale (BCIS), Color Trial Test (CTT-1, CTT-2), d2 psychological tests, Acceptance of Illness Scale (AIS), Self-efficacy Scale (GSES), Quantitative Electroencephalogram Biofeedback (QEEG-BF), auditory event-related potentials (ERPs), and serum levels of brain-derived neurotrophic factor (BDNF). The subjects were mentally stable male schizophrenia patients who had been in remission. They were divided into two groups which received different types of rehabilitation for three months. Group 1 patients followed a standard rehabilitation and Group 2 patients received GSR Biofeedback (galvanic skin response Biofeedback, GSR-BF) training. Pretherapy and posttherapy measurements were made for each group. Experimental rehabilitation based on GSR-BF training resulted in regulatory control of neurophysiological mechanisms, and the parameters obtained demonstrated improvement in the subjects’ cognitive and social function. The following therapy outcomes were observed: (1) reduce psychopathological symptoms (2) improving cognitive (concentration, attention) and social functions (3) increase in the neurotrophic factor BDNF. GSR-BF can be used as an alternative to conventional rehabilitation in schizophrenia patients.

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Can brain-derived neurotrophic factor (BDNF) be an indicator of effective rehabilitation interventions in schizophrenia?

Cited by 21 publications

References 79 publications

Effects of Transcranial Alternating Current Stimulation and Neurofeedback on Alpha (EEG) Dynamics: A Review

Effects of Transcranial Alternating Current Stimulation and Neurofeedback on Alpha (EEG) Dynamics: A Review

Perineuronal Nets and Their Role in Synaptic Homeostasis

Reinforcement of Self-Regulated Brain Activity in Schizophrenia Patients Undergoing Rehabilitation

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