Can control of gut microbiota be a future therapeutic option for inflammatory bowel disease?

Nishida, Atsushi; Nishino, Kazumi; Sakai, Keitaro; Owaki, Yuji; Noda, Yoshika; Imaeda, Hirotsugu

doi:10.3748/wjg.v27.i23.3317

Cited by 34 publications

(20 citation statements)

References 64 publications

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“…A large clinical trial studied the efficacy of E. coli Nissle 1917 in maintaining the remission after clinical treatment in patients with UC ( n = 120) compared with mesalazine treatment (1,500 mg/day). It was shown that E. coli Nissle 1917 and mesalazine were equivalent in maintaining the remission of UC ( Nishida et al., 2021 ). IBD patients generally present symptoms of iron deficiency, and the iron-deficient intestinal microenvironment is more conducive to the intestinal colonization and curative effect of E. coli Nissle 1917.…”

Section: Microbiota-targeted Treatment In Ibdmentioning

confidence: 99%

The Gut Microbiota in Inflammatory Bowel Disease

Qiu

Ishimoto

et al. 2022

Front. Cell. Infect. Microbiol.

214

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Epidemiological surveys indicate that the incidence of inflammatory bowel disease (IBD) is increasing rapidly with the continuous growth of the economy. A large number of studies have investigated the relationship between the genetic factors related to the susceptibility to IBD and the gut microbiota of patients by using high-throughput sequencing. IBD is considered the outcome of the interaction between host and microorganisms, including intestinal microbial factors, abnormal immune response, and a damaged intestinal mucosal barrier. The imbalance of microbial homeostasis leads to the colonization and invasion of opportunistic pathogens in the gut, which increases the risk of the host immune response and promotes the development of IBD. It is critical to identify the specific pathogens related to the pathogenesis of IBD. An in-depth understanding of various pathogenic factors is of great significance for the early detection of IBD. This review highlights the role of gut microbiota in the pathogenesis of IBD and provides a theoretical basis for the personalized approaches that modulate the gut microbiota to treat IBD.

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Section: Microbiota-targeted Treatment In Ibdmentioning

confidence: 99%

The Gut Microbiota in Inflammatory Bowel Disease

Qiu

Ishimoto

et al. 2022

Front. Cell. Infect. Microbiol.

214

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“…Acetic acid produced by bacterial fermentation can be absorbed and utilized by the host and is an important source of host energy, providing about 10% of the total daily energy of the human body. After absorbed by blood, propionic acid catabolizes in the liver, participating in the process of pyruvate reversal into glucose, and may inhibit the synthesis of fat; Butyric acid is mainly used by epithelial cells and is the main energy source of epithelial cells[ 132 ].…”

Section: Tryptophan Metabolismmentioning

confidence: 99%

Role of metabolites derived from gut microbiota in inflammatory bowel disease

Wen¹,

Duan²

2022

WJCC

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Over the past two decades, it is improved gut microbiota plays an important role in the health and disease pathogenesis. Metabolites, small molecules produced as intermediate or end products of microbial metabolism, is considered as one of the major interaction way for gut microbiota with the host. Bacterial metabolisms of dietary substrates, modification of host molecules or bacteria are the major source of metabolites. Signals from microbial metabolites affect immune maturation and homeostasis, host energy metabolism as well as mucosal integrity maintenance. Based on many researches, the composition and function of the microbiota can be changed, which is also seen in the metabolite profiles of patients with inflammatory bowel disease (IBD). Additionally, some specific classes of metabolites also can trigger IBD. In this paper, definition of the key classes of microbial-derived metabolites which are changed in IBD, description of the pathophysiological basis of association and identification of the precision therapeutic modulation in the future are the major contents.

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“…While FMT treatment is mostly safe, a small number of patients have experienced infection and death after the treatment. Therefore, further studies are needed to prove the reliability of FMT treatment for IBD [ 105 ]. Interestingly, supplementary treatment with probiotics ensures the improvement of the intestinal flora, enhancement of intestinal barrier function, a reduction in intestinal inflammation, and a general relief of symptoms in IBD patients [ 106 ].…”

Section: Interaction Between Intestinal Flora and Bile Acidsmentioning

confidence: 99%

Interactive Relationships between Intestinal Flora and Bile Acids

Guo

Okpara

et al. 2022

IJMS

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The digestive tract is replete with complex and diverse microbial communities that are important for the regulation of multiple pathophysiological processes in humans and animals, particularly those involved in the maintenance of intestinal homeostasis, immunity, inflammation, and tumorigenesis. The diversity of bile acids is a result of the joint efforts of host and intestinal microflora. There is a bidirectional relationship between the microbial community of the intestinal tract and bile acids in that, while the microbial flora tightly modulates the metabolism and synthesis of bile acids, the bile acid pool and composition affect the diversity and the homeostasis of the intestinal flora. Homeostatic imbalances of bile acid and intestinal flora systems may lead to the development of a variety of diseases, such as inflammatory bowel disease (IBD), colorectal cancer (CRC), hepatocellular carcinoma (HCC), type 2 diabetes (T2DM), and polycystic ovary syndrome (PCOS). The interactions between bile acids and intestinal flora may be (in)directly involved in the pathogenesis of these diseases.

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Can control of gut microbiota be a future therapeutic option for inflammatory bowel disease?

Cited by 34 publications

References 64 publications

The Gut Microbiota in Inflammatory Bowel Disease

The Gut Microbiota in Inflammatory Bowel Disease

Role of metabolites derived from gut microbiota in inflammatory bowel disease

Interactive Relationships between Intestinal Flora and Bile Acids

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