Can fractional lasers enhance transdermal absorption of topical lidocaine in an in vivo animal model?

Abstract

This study demonstrates that laser pretreatment significantly increases absorption of topical lidocaine so that it is detectable in the blood and that manipulating laser settings can affect drug absorption. Future work will look at translating this effect into clinical benefit.

In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

“…FLMA can promote penetration of the particles and drugs into dermis to the depth defined by parameters of laser system [7][8][9][10][11][21][22][23]. Thus, in Ref [21] authors used the laser fluence 125 J/cm 2 to induce areas with ablative depth up to 500 μm within the area of ablation of 1cm 2 .…”

“…Thus, in Ref [21] authors used the laser fluence 125 J/cm 2 to induce areas with ablative depth up to 500 μm within the area of ablation of 1cm 2 . The developed FLMA-protocol has allowed us to provide a comparable ablative depth (~400 μm) with the significantly smaller (~0.1 cm 2 ) area in rat skin in vivo at the approximately similar laser fluence ~100 J/cm 2 that promotes much better skin healing.…”

The impact of treatment density and molecular weight for fractional laser-assisted drug delivery

“…In recent years it has been demonstrated in several in vitro and in vivo experimental studies that pretreatment of the skin with ablative fractional lasers (AFXL) enhances the uptake of topically applied drugs into the skin, facilitates intracutaneous biodistribution and also enhances transcutaneous delivery [6][7][8][9][10][11][12][13][14][15][16][17]. Ablative fractional procedures are available with carbon dioxide (CO 2 ; 10,600 nm), erbium: yttrium aluminum garnet (Er:YAG; 2940 nm) and yttrium scandium gallium garnet (YSGG; 2790 nm) lasers [18][19][20].…”

Non-ablative fractional laser assists cutaneous delivery of small- and macro-molecules with minimal bacterial infection risk

“…The lasers can precisely control the ablation degree by adjustment of the energy and etched depth (Haedersdal et al, 2010;Yu et al, 2011;Oni et al, 2012;. The skin is exposed by the laser in a non-contact manner without the A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 5 contamination risk (Chen et al, 2012).…”