Can garlic oil ameliorate diabetes-induced oxidative stress in a rat liver model? A correlated histological and biochemical study

Abdultawab, Hanem Saad; Ayuob, Nasra Naeim

doi:10.1016/j.fct.2013.07.009

Cited by 15 publications

(4 citation statements)

References 41 publications

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“…Several studies have indicated the development of oxidative stress in diabetic rats via increase in TBARS or lipid peroxide levels (1,4,5) and decrease in antioxidant enzymes such as CAT, GPx activities (29) and SOD activity (9). In this study, it was found that the kidney and liver TBARS levels were significantly enhanced, while the kidney and liver SOD and CAT activities were significantly reduced in the DC rats compared to the control rats.…”

Section: Discussionmentioning

confidence: 48%

Effects of Allium tuncelianum on hyperglycemia and oxidative stress in the kidney and liver tissues in rats with diabetes mellitus induced by streptozotocin

Atila

Bilgili

Uslu

et al. 2019

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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In this study, it was aimed to investigate the effects of Allium tuncelianum extract on hyperglycemia and oxidative stress in the kidney and liver tissues in rats with diabetes mellitus induced by streptozotocin. The rats were randomly divided into 4 groups with 10 animals in each group: Control group (C) was intraperitoneally (i.p.) treated with physiological saline solution, diabetic control (DC) group i.p. with a single dose of 50 mg/kg streptozotocin (STZ), diabetic + insulin (D+I) group i.p. with a single dose of 50 mg/kg STZ and subcutaneously (s.c.) with 2 IU insulin for 28 days (Levemir Flexpen), diabetic + Allium tuncelianum extract (D+AT) group i.p. with a single dose of 50 mg/kg STZ and orally with 250 mg/kg Allium tuncelianum extract for 28 days. The serum glycated hemoglobin (HbA1c), insulin levels and the kidney and liver thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), and catalase (CAT) activities were determined by using ELISA kits. Increased blood glucose levels (p<0.001), increased TBARS levels (p<0.001, p<0.01 respectively), and decreased SOD and CAT activities (p<0.001) in the kidney and liver tissue homogenates were determined in diabetic control group compared to control group. Allium tuncelianum extract had potent antioxidant activities in the diabetic rats, and demonstrated improvement effects by increasing insulin levels, decreasing glycated hemoglobin levels, and attenuating oxidative stress in the diabetic rats. This study suggests that Allium tuncelianum extract may have therapeutic potential for patients with diabetes.

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Section: Discussionmentioning

confidence: 48%

Effects of Allium tuncelianum on hyperglycemia and oxidative stress in the kidney and liver tissues in rats with diabetes mellitus induced by streptozotocin

Atila

Bilgili

Uslu

et al. 2019

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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“…Garlic essential oil can also improve Fe‐NTA‐mediated renal injury by inhibiting the activities of antioxidant enzymes such as CAT, glutathione peroxidase, glutathione reductase, glucose‐6‐phosphate dehydrogenase, and glutathione S‐transferase. In addition, gallic essential oil can ameliorate diabetes‐induced oxidative stress in the rat liver model and normalize oxidative stress in alloxan‐induced diabetic rates (Iqbal & Athar, 1998 ; Saad Abdultawab & Ayuob, 2013 ).…”

Section: Bioactivities Of Garlic Essential Oilmentioning

confidence: 99%

Bioactivity and health effects of garlic essential oil: A review

Huang

Liu

Wang

et al. 2023

Food Science & Nutrition

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Garlic (Allium sativum L.), the underground bulb of the Allium plant in the family Liliaceae, is a common and popular spice that has historically been used to prevent and treat many different diseases such as pain, deafness, diarrhea, tumors, and other healthy problems. Garlic essential oil contains a variety of organosulfur compounds, such as the most representative diallyl disulfides (DADS) and diallyl trisulfides (DATS), which have attracted great interest in medicine, food, and agriculture because of their rich biological activities. This paper reviews the research progress on the composition and bioactivities of garlic essential oil mixtures and the bioactivity of some typical monomeric sulfides in garlic essential oil. The active mechanisms of representative sulfides in garlic essential oil were analyzed, and the applications of garlic essential oil in functional food, food additives, and clinical treatment were discussed. Combined with the current research status, the limitations and development direction of garlic essential oil in the study of molecular mechanism were discussed, which is of great significance to the development of garlic essential oil as a natural and safe alternative medicine for treatment.

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“…This causes the activity of the antioxidant defense system to deplete, which promotes the generation of de novo free radicals [5,6,11]. Nowadays, antidiabetic drugs such as biguanide and sulfonylurea are more available for reducing hyperglycemia in diabetes mellitus, but unfortunately, available drugs have many side effects on diabetic cases [12]. Therefore, several patients in many cases use a combination of herbal remedies and oral hypoglycemic agents [4].…”

Section: Introductionmentioning

confidence: 99%

Radical Scavenging and Antioxidant Effects of Garlic Oil and Vitamin E in Streptozotocin-Induced Diabetic Rats

Balkhair¹,

Al‐Seeni²,

EL-Sherif³

2021

Int j pharm phytopharm res

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The antioxidant, antidiabetic, radical scavenging activity of garlic oil, Vit E, and their combination were investigated in male albino Wistar rats. Forty rats were divided into five groups (n=8). One group was considered as the negative control (G1), and the rest were injected with streptozotocin for inducing diabetes and divided into 4 groups as follows. group (G2): as the positive control, (G3): treated with garlic oil, (G4): treated with Vit E, and (G5): treated with a mixture of both garlic oil and Vit E. The streptozotocin positive control group (G2) showed decreased antioxidants, high-density lipoprotein, blood glucose, lipid peroxidation, cholesterol, and triglycerides, as well as decreased lipoprotein-cholesterol densities. The treatment of diabetes in G3, G4, and G5 by garlic oil, Vit E, and their mixture, respectively enhanced the antioxidant and decreased the blood glucose, lipid profile, and lipid peroxidation. In G5, the garlic oil and Vit E combination showed better protection against streptozotocin-induced diabetes than either garlic oil or Vit E, separately.

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Can garlic oil ameliorate diabetes-induced oxidative stress in a rat liver model? A correlated histological and biochemical study

Cited by 15 publications

References 41 publications

Effects of Allium tuncelianum on hyperglycemia and oxidative stress in the kidney and liver tissues in rats with diabetes mellitus induced by streptozotocin

Effects of Allium tuncelianum on hyperglycemia and oxidative stress in the kidney and liver tissues in rats with diabetes mellitus induced by streptozotocin

Bioactivity and health effects of garlic essential oil: A review

Radical Scavenging and Antioxidant Effects of Garlic Oil and Vitamin E in Streptozotocin-Induced Diabetic Rats

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