Can Long-lasting Insecticide-treated Bednets with Holes Protect Children from Malaria?

Nonaka, Daisuke; Maazou, Abani; Yamagata, Shigeo; Oumarou, Issofou; Uchida, Takako; Yacouba, Honoré Jg; Toma, Nami; Takeuchi, Rie; Kobayashi, Jun; Mizoue, Tetsuya

doi:10.2149/tmh.2013-21

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…Effective, long-lasting insecticides [ 21 – 23 ] are essential to the future of vector control, but these efforts are likely to be seriously undermined if the physical integrity of LLINs does not markedly improve [ 24 – 26 ]. In this study, the primary causes of holes and thereby loss of physical integrity in LLINs were identified, so as to understand why these important vector control products are prone to rapid deterioration after only a few years of use.…”

Section: Discussionmentioning

confidence: 99%

The causes of holes and loss of physical integrity in long‐lasting insecticidal nets

Wheldrake

Guillemois

Arouni

et al. 2021

Malar J

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Background Long-lasting insecticidal nets (LLINs) are expected to last for at least 3 years, but whilst this may be achieved from an insecticidal perspective, physical protection is frequently compromised much earlier because of the rapid accumulation of holes during use. To understand why LLINs are so susceptible to loss of physical integrity, thousands of hole damage sites in LLINs retrieved from the field in Africa and Asia were forensically studied to identify the persistent underlying causes. Methods A total of 525 LLINs consisting of six different brands from five different countries across Africa and Asia were collected from the field after 1 to 3 years in use. More than 42,000 individual sites of hole damage were analysed based on the morphology and size of each individual hole, aided by optical microscopy (OM) and scanning electron microscopy (SEM). The fracture morphology enabled positive identification of the underlying mechanisms of the damage. Results Across all LLINs and geographical settings, mechanical damage is the primary cause of holes and loss of physical integrity in LLINs (63.14% by frequency and 81.52% by area). Snagging is the single most frequent mechanical damage mechanism, whilst the largest sized holes in LLINs result from seam failure and tearing. Abrasion and hole enlargement are also responsible for a progressive loss in the physical integrity of nets. Collectively, these five modes of mechanical damage can be expected to result from normal use of LLINs by households. Evidence of deliberate cutting, burn holes and rodent damage was observed to a lesser degree, which LLINs are not designed to withstand. Conclusions Loss of physical integrity in LLINs is an inevitable consequence of using a vector control product that has an inherently low resistance to mechanical damage during normal use. To improve performance, new specifications based on laboratory textile testing is needed, to assess the resistance of LLIN products to the primary causes of mechanical damage when in use, which are snagging, tearing, abrasion and hole enlargement. Seam construction also needs to meet a revised minimum standard to reduce the risk of a rapid loss of physical integrity during use.

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Section: Discussionmentioning

confidence: 99%

The causes of holes and loss of physical integrity in long‐lasting insecticidal nets

Wheldrake

Guillemois

Arouni

et al. 2021

Malar J

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The protective effectiveness of control interventions for malaria prevention: a systematic review of the literature

2017

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Background: Thanks to a considerable increase in funding, malaria control interventions (MCI) whose efficacy had been demonstrated by controlled trials have been largely scaled up during the last decade. Nevertheless, it was not systematically investigated whether this efficacy had been preserved once deployed on the field. Therefore, we sought the literature to assess the disparities between efficacy and effectiveness and the effort to measure the protective effectiveness (PE) of MCI. Methods: The PubMed database was searched for references with keywords related to malaria, to control interventions for prevention and to study designs that allow for the measure of the PE against parasitemia or against clinical outcomes. Results: Our search retrieved 1423 references, and 162 articles were included in the review. Publications were scarce before the year 2000 but dramatically increased afterwards. Bed nets was the MCI most studied (82.1%). The study design most used was a cross-sectional study (65.4%). Two thirds (67.3%) were conducted at the district level or below, and the majority (56.8%) included only children even if the MCI didn’t target only children. Not all studies demonstrated a significant PE from exposure to MCI: 60.6% of studies evaluating bed nets, 50.0% of those evaluating indoor residual spraying, and 4/8 showed an added PE of using both interventions as compared with one only; this proportion was 62.5% for intermittent preventive treatment of pregnant women, and 20.0% for domestic use of insecticides. Conclusions: This review identified numerous local findings of low, non-significant PE –or even the absence of a protective effect provided by these MCIs. The identification of such failures in the effectiveness of MCIs advocates for the investigation of the causes of the problem found. Ideal evaluations of the PE of MCIs should incorporate both a large representativeness and an evaluation of the PE stratified by subpopulations.

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Can Long-lasting Insecticide-treated Bednets with Holes Protect Children from Malaria?

Cited by 2 publications

References 16 publications

The causes of holes and loss of physical integrity in long‐lasting insecticidal nets

The causes of holes and loss of physical integrity in long‐lasting insecticidal nets

The protective effectiveness of control interventions for malaria prevention: a systematic review of the literature

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