Can Preterm Labour Be Predicted in Low Risk Pregnancies? Role of Clinical, Sonographic, and Biochemical Markers

Tripathi, Reva; Tyagi, Shantanu; Singh, Nilanchali; Mala, YM; Singh, Chanchal

doi:10.1155/2014/623269

Cited by 12 publications

(12 citation statements)

References 25 publications

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“…Our results are concurrent with Singh B, et al [16], Tripathi R, et al [17], Meyer RE, et al [18], Moawad AH, et al [19], Huras H, et al [20] and Goldenberg RL, et al [21], Singh B, et al [16] reported an increase in serum ALP during PTD.…”

Section: Discussionsupporting

confidence: 87%

Ceruloplasmin and Alkaline Phosphatase Levels in Preterm Delivery

Kondhalkar

Kumar

2019

IJBcRR

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Introduction: Preterm birth (PTB) is a major determinant of neonatal mortality and morbidity. Preterm babies are prone to serious illness or death during the neonatal period. PTB is one of the unresolved problems in clinical obstetrics and one of the greatest threats to the developing fetus, there is need to determine predictive biomarker for preterm delivery. Therefore present study aimed to assess serum levels of ceruloplasmin and Alkaline phosphatase in preterm and full-term delivery. Materials and Methods: The present study includes total 80 subjects that comprise forty women presenting with preterm onset of labor followed by delivery and forty women who delivered at term served as controls. Blood Samples from the subjects were obtained for ceruloplasmin and Alkaline phosphatase estimation, when patient was in labor. Serum ceruloplasmin and alkaline phosphatase measured spectrophotometrically. Serum ceruloplasmin was estimated by Herbert A Ravin and Henry et al. method. Serum alkaline phosphatase was estimated by Kinetic p-NPP method. Results: Serum ceruloplasmin levels were significantly increased (P<0.001) in preterm delivery as compared to full term delivery. Alkaline phosphatase levels are significantly increased in preterm delivery (p<0.001) as compared to full term delivery. Conclusion: Our study showed that elevated levels of ceruloplasmin and alkaline phosphatase may be associated with preterm delivery in asymptomatic pregnant women. The elevated ALP may be due to mild chronic subclinical infection which may be responsible for preterm delivery. Ceruloplasmin is acute phase reactant, increased due to an antioxidant defence mechanism against oxidative stress.

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Section: Discussionsupporting

confidence: 87%

Ceruloplasmin and Alkaline Phosphatase Levels in Preterm Delivery

Kondhalkar

Kumar

2019

IJBcRR

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“…17 Despite decades of research, we are no closer to finding answers in terms of prediction and hence prevention of preterm labour. 18 Documented risk factors like multiple pregnancy, placenta praevia and precious pregnancy/bad obstetric history are usually associated with indicated preterm births and hence, these were excluded from the present study as the study primarily aimed to identify non-traditional risk factors for spontaneous preterm births.…”

Section: Discussionmentioning

confidence: 99%

Assessment of risk factors and predictors for spontaneous pre-term birth in a South Indian antenatal cohort

Rao

Bhat

Vandana

et al. 2018

Clinical Epidemiology and Global Health

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To assess incidence of spontaneous preterm births and determine biochemical and obstetric risk factors for spontaneous pre-term births in a cohort of antenatal women visiting a secondary care hospital. Methods: A prospective cohort study was designed to include 1420 pregnant women coming for antenatal care at a secondary care hospital. The cohort was followed throughout pregnancy and relevant history, obstetric and ultrasonographic examination and biochemical investigations was carried out in 2nd (20-24 weeks period of gestation) and 3rd trimester (28-32 weeks period of gestation). Outcome of delivery was noted for all the subjects. Results: A total of 1133 women were recruited. Among the 1071 respondents, 11 had abortions, 93.1% delivered at term while 5.9% had preterm deliveries. Preterm deliveries were noted among 6.5% women with short stature, 13.3% with cervical length <2.5 cms and 5.2% among women with anaemia. Statistically significant association was noted between Oligohydramnios, IUGR and preterm births. Salivary estriol was lower in women who had preterm births as compared to term births. Conclusions: The incidence of preterm births (5.9%) was low in the present cohort. Oligohydramnios and Intrauterine Growth Retardation (IUGR) were identified as significant risk factors for preterm births. Conventional risk factors like short cervix, short stature and biochemical inflammatory markers were not identified as predictors of prematurity. Lower levels of salivary estriol identified among women at risk of preterm births demonstrates the utility of the test as a non-invasive investigation for early identification of preterm births.

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“…These studies have shown that moderate to severe anemia (9 to 10gm/dl) has been associated with a 2-3 fold increased risk of preterm labor. 9 In another work performed in Germany by Goepel et al, it was seen that preterm labor was recorded in 48% pregnant women with serum ferritin levels below 10 micrograms/liter. In our study about 58% patients had serum ferritin below 10 micrograms/liter.…”

Section: Discussionmentioning

confidence: 93%

Anemic Patients

Majeed

Adnan

Mahmood

et al. 2015

TPMJ

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Pregnant women are particularly considered to be the most vulnerable groupbecause of the additional demands that are made on maternal stores during pregnancy. Theiron deficiency anemia is the most common nutritional deficiency problems in females and isresponsible of high maternal death rate in our society. Objectives: To determine the relationshipof frequency and severity of iron deficiency anemia to preterm labor and eventual perinatalout come in anemic patients. Study Design: It was a case control study. Study Setting: InObstetrics and Gynecology Unit-III, Sir Ganga Ram hospital, Lahore from July 2012 to June2013. Methodology: The study was conducted on 200 patients (100 cases and 100 controls)were studied. Cases were patients admitted in labor room with preterm labor and Controlswere females in labor at term at. Convenience sampling was done. On admission relevanthistory taking examination and investigation were done. The data was collected on a Performa.Results: There were 50 patients with anemia amongst the patients with preterm labor. In thecontrol group, 40 patients were suffering from anemia. In the patients with preterm labor themean hemoglobin was 9.83 grams/deciliter. In the control group the mean hemoglobin was10.3gm/dl. (Pregnant women having hemoglobin <10gm/dl are considered to be anemic). Theodds ratio was calculated to be 3.4 and P value was <0.05. Conclusions: Iron deficiencyanemia was associated with increased risk for low birth weight, preterm delivery, and perinatalmortality. The frequency of iron-deficiency anemia was seen in both groups of pregnant women.

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Can Preterm Labour Be Predicted in Low Risk Pregnancies? Role of Clinical, Sonographic, and Biochemical Markers

Cited by 12 publications

References 25 publications

Ceruloplasmin and Alkaline Phosphatase Levels in Preterm Delivery

Ceruloplasmin and Alkaline Phosphatase Levels in Preterm Delivery

Assessment of risk factors and predictors for spontaneous pre-term birth in a South Indian antenatal cohort

Anemic Patients

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