Can Saliva Proteins Be Used to Predict the Onset of Acute Myocardial Infarction among High-Risk Patients?

Rahim, Mohd Aizat Abdul; Rahim, Zubaidah Haji Abdul; Ahmad, Wan Azman Wan; Hashim, Onn Haji

doi:10.7150/ijms.11280

Cited by 42 publications

(45 citation statements)

References 52 publications

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“…Proteomics is a large-scale comprehensive study of proteins including information on protein abundances and modification along with their interacting networks 11. Proteomic analysis is defined as the powerful tool in studying the changes in protein expression and the identification of biomarkers for pathogenic processes 12-14. To our knowledge, no precise mechanism has been identified to explain the relationship between gut-microbiota-lacking and host.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the serum and liver proteomes in gut-microbiota-lacking mice

et al. 2017

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Current nutrition research is focusing on health promotion, disease prevention, and performance improvement for individuals and communities around the world. The humans with required nutritional ingredients depend on both how well the individual is provided with balanced foods and what state of gut microbiota the host has. Studying the mutually beneficial relationships between gut microbiome and host is an increasing attention in biomedical science. The purpose of this study is to understand the role of gut microbiota and to study interactions between gut microbiota and host. In this study, we used a shotgun proteomic approach to reveal the serum and liver proteomes in gut-microbiota-lacking mice. For serum, 15 and 8 proteins were uniquely detected in specific-pathogen-free (SPF) and germ-free (GF) mice, respectively, as well as the 3 and 20 proteins were significantly increased and decreased, respectively, in GF mice compared to SPF mice. Among the proteins of the serum, major urinary protein 1 (MUP-1) of GF mice was significantly decreased compared to SPF mice. In addition, MUP-1 expression is primarily regulated by testosterone. Lacking in gut flora has been implicated in many adverse effects, and now we have found its pathogenic root maybe gut bacteria can regulate the sex-hormone testosterone levels. In the liver, 8 and 22 proteins were uniquely detected in GF mice and SPF mice, respectively, as well as the 14 and 30 proteins were significantly increased and decreased, respectively, in GF mice compared to SPF mice. Furthermore, ingenuity pathway analysis (IPA) indicated that gut microbiota influence the host in cancer, organismal injury and abnormalities, respiratory disease; cell cycle, cellular movement and tissue development; cardiovascular disease, reproductive system disease; and lipid metabolism, molecular transport and small molecule biochemistry. Our findings provide more detailed information of the role of gut microbiota and will be useful to help study gut bacteria and disease prevention.

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Section: Introductionmentioning

confidence: 99%

Characterization of the serum and liver proteomes in gut-microbiota-lacking mice

et al. 2017

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“…Sampling of human saliva is an attractive means to diagnose and monitor diseases since the saliva may be collected easily and noninvasively. Analysis of the saliva may also be beneficial to predict the progression of future diseases (14,21,22). As a clinical tool, saliva has many advantages over serum, including ease of collection, storing, and shipping.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of salivary oxidative parameters in overweight and obese young adults

Chielle

Casarin

2017

Arch. Endocrinol. Metab.

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Background: Obesity is characterized by a deposition of abnormal or excessive fat in adipose tissue, and is linked with a risk of damage to several metabolic and pathological processes associated with oxidative stress. To date, salivary oxidative biomarkers have been minimally explored in obese individuals. Thus, the aim of this study was to assess the concentrations of salivary oxidative biomarkers (ferric-reducing antioxidant power, uric acid, sulfhydryl groups) and lipid peroxidation in obese and overweight young subjects. Materials and methods: Levels of lipid peroxidation, ferricreducing antioxidant power, uric acid, and SH groups were determined in the saliva and serum of 149 young adults, including 54 normal weight, 27 overweight, and 68 obese individuals. Anthropometric measurements were also evaluated. Results: Salivary levels of ferric-reducing antioxidant power, sulfhydryl groups, and lipid peroxidation, as well as serum levels of ferric-reducing antioxidant power, uric acid, and lipid peroxidation were higher in obese patients when compared with individuals with normal weight. There were correlations between salivary and serum ferric-reducing antioxidant power and salivary and serum uric acid in the obese and normal-weight groups. Conclusions: Our results indicate that the increase in salivary levels of ferric-reducing antioxidant power, sulfhydryl groups, and lipid peroxidation, and serum levels of ferric-reducing antioxidant power, uric acid, and lipid peroxidation could be related to the regulation of various processes in the adipose tissue. These findings may hold promise in identifying new oxidative markers to assist in diagnosing and monitoring overweight and obese patients. Arch Endocrinol Metab. 2017;61(2):152-9.

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“…Moreover, studies have investigated the role of salivary proteomic analyses to predict myocardial infarction, diabetes mellitus types 1 and 2, and pulmonary diseases (67–69). While the pediatric patient population is ripe for similar diagnostic advances, here too, an investigator must pay specific attention to unique circumstances, including ongoing and rapid development as well as hormonal changes associated with puberty, which may impact proteomic analyses in newborns, infants, and children.…”

Section: Salivary “Omics”mentioning

confidence: 99%

Salivary Diagnostics in Pediatrics: Applicability, Translatability, and Limitations

Hassaneen

Maron

2017

Front. Public Health

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In the last decade, technological advances, combined with an improved appreciation of the ability of saliva to inform caregivers about both oral health and systemic disease, have led to the emergence of salivary diagnostic platforms. However, the majority of these assays have targeted diseases that more commonly affect the adult population, largely neglecting infants and children who arguably could benefit the most from non-invasive assessment tools for health monitoring. Gaining access into development, infection, and disease through comprehensive “omic” analyses of saliva could significantly improve care and enhance health access. In this review, we will highlight novel applications of salivary diagnostics in pediatrics across the “omic” spectrum, including at the genomic, transcriptomic, proteomic, microbiomic, and metabolomic level. The challenges to implementing salivary platforms into care, including the effects of age, diet, and developmental stage on salivary components, will be reviewed. Ultimately, large-scale, multicenter trials must be performed to establish normative biomarker values across the age spectrum to accurately discriminate between health and disease. Only then can salivary diagnostics truly translate into pediatric care.

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Can Saliva Proteins Be Used to Predict the Onset of Acute Myocardial Infarction among High-Risk Patients?

Cited by 42 publications

References 52 publications

Characterization of the serum and liver proteomes in gut-microbiota-lacking mice

Characterization of the serum and liver proteomes in gut-microbiota-lacking mice

Evaluation of salivary oxidative parameters in overweight and obese young adults

Salivary Diagnostics in Pediatrics: Applicability, Translatability, and Limitations

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