Canadian Home Parenteral Nutrition (HPN) Registry

Fernandes, Gail; Kaila, Brinderjit; Jeejeebhoy, K. N.; Gramlich, Leah; Armstrong, David; Allard, Johane P.

doi:10.1177/0148607111434599

Cited by 26 publications

(29 citation statements)

References 41 publications

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“…Canada established a registry in 2006 to gather HPN patient outcome information and determined that the registry was a valid tool to assess clinical parameters 11 . The initial report from the Registry included 150 patients from 5 HPN programs in Canada 12 .…”

Section: Introductionmentioning

confidence: 99%

Characteristics of a Cohort of Home Parenteral Nutrition Patients at the Time of Enrollment in the Sustain Registry

Winkler

DiMaria‐Ghalili

Guenter

et al. 2015

J Parenter Enteral Nutr

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Section: Introductionmentioning

confidence: 99%

Characteristics of a Cohort of Home Parenteral Nutrition Patients at the Time of Enrollment in the Sustain Registry

Winkler

DiMaria‐Ghalili

Guenter

et al. 2015

J Parenter Enteral Nutr

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“…Figure 1). 9 Data from other European and Canadian centres would seem to suggest similar aetiologies, 10,11 whereas a diagnosis of cancer forms a principle indication for HPN in the USA (42%) and Japan (40%).…”

Section: Introductionmentioning

confidence: 99%

Review article: the management of long‐term parenteral nutrition

Dibb

Teubner

Theis

et al. 2013

Aliment Pharmacol Ther

140

108

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SummaryBackgroundHome parenteral nutrition (HPN) is currently the management of choice for patients with chronic intestinal failure.AimTo summarise the major issues in delivering long‐term parenteral nutrition (>3 months) and assess outcome as per complications, mortality and quality of life. To assess the evidence for the therapeutic use of trophic factors such as teduglutide and to review evolving therapeutic options in the treatment of chronic intestinal failure.MethodsA literature search using PubMed and MEDLINE databases was performed.ResultsSafe delivery of HPN relies upon individualised formulations of parenteral nutrition administered via carefully maintained central venous catheters by trained patients or carers, supported by a skilled multidisciplinary team. Early diagnosis and treatment of complications including catheter‐associated blood stream infection (reported incidence 0.14–0.83 episodes/patient‐year on HPN) and central venous thrombosis (reported incidence 0.03 episodes/patient‐year) is important to minimise mortality and morbidity. There is a significant variation in the reported incidence of both hepatobiliary complications (19–75%) and advanced liver disease (0–50%). Five‐year survival rates in large centres are reported between 60% and 78% with survival primarily related to underlying diagnosis. Long‐term survival remains higher on HPN than with intestinal transplantation. The role of intestinal lengthening procedures is yet to be validated in adults.ConclusionsHome parenteral nutrition delivered by skilled nutrition teams has low incidences of catheter‐related complications. Most deaths relate to the underlying disease. Therapies such as teduglutide and small bowel transplantation appear promising, but home parenteral nutrition appears likely to remain the bedrock of management in the near term.

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“…Patients with SBS had severe malabsorption associated with high‐output fistulas, ostomy, or significant diarrhea. SBS included causes such as Crohn's disease, ischemic bowel, and necrotizing enterocolitis 7 . Non‐SBS included patients who had poor oral intake that may or may not be associated with malabsorption but no significant diarrhea or high‐output fistula or ostomy.…”

Section: Resultsmentioning

confidence: 99%

“…Also, in most provinces, such specialized serum testing is not covered by the provincial government, and patients may not be able to afford or are unwilling to assume the laboratory costs. A complete description of the Canadian HPN Registry has been previously published 6 , 7 …”

Section: Methodsmentioning

confidence: 99%