Cancer‐Cell‐Biomimetic Nanoparticles for Targeted Therapy of Homotypic Tumors

Sun, Hongwei; Su, Jinghan; Meng, Qingshu; Yin, Qi; Chen, Lingli; Gu, Wanyi; Zhang, Pengcheng; Zhang, Zhiwen; Wang, Siling

doi:10.1002/adma.201602173

Cited by 527 publications

(403 citation statements)

References 37 publications

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“…[18,19] Sometimes,alarge number of nanoparticles adheres around the blood vessels,w hich causes blood clots. [21][22][23][24][25][26][27][28][29] Recent studies report that cell membranes can be extracted and reconstructed on the surface of nanocarriers for biomedical applications. [21][22][23][24][25][26][27][28][29] Recent studies report that cell membranes can be extracted and reconstructed on the surface of nanocarriers for biomedical applications.…”

mentioning

confidence: 99%

Magnetic Mesoporous Silica Nanoparticles Cloaked by Red Blood Cell Membranes: Applications in Cancer Therapy

et al. 2018

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Targeted drug delivery is an emerging technological strategy that enables nanoparticle systems to be responsive for tumor therapy. Magnetic mesoporous silica nanoparticles (MMSNs) were cloaked with red blood cell membrane (RBC). This integrates long circulation, photosensitizer delivery, and magnetic targeting for cancer therapy. In vivo experiments demonstrate that RBC@MMSNs can avoid immune clearance and achieve magnetic field (MF)-induced high accumulation in a tumor. When light irradiation is applied, singlet oxygen rapidly generates from hypocrellin B (HB)-loaded RBC@MMSN and leads to the necrosis of tumor tissue. Such a RBC-cloaked magnetic nanocarrier effectively integrates immunological adjuvant, photosensitizer delivery, MF-assisted targeting photodynamic therapy, which provides an innovative strategy for cancer therapy.

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confidence: 99%

Magnetic Mesoporous Silica Nanoparticles Cloaked by Red Blood Cell Membranes: Applications in Cancer Therapy

et al. 2018

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“…Leukocyte and cancer-cell membranes have also been investigated to enhance the blood circulation and tumour accumulation. 125, 126 …”

Section: Tumour Vascular Abnormalitiesmentioning

confidence: 99%

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

et al. 2017

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Nanovehicles can efficiently carry and deliver anticancer agents to tumour sites. Compared with normal tissue, the tumour microenvironment has some unique properties, such as vascular abnormalities, hypoxia and acidic pH. There are many types of cells including tumour cells, macrophages, immune and fibroblasts cells, fed by defective blood vessels in the solid tumour. Exploiting the tumour microenvironment can benefit the design of nanoparticles for enhanced therapeutic effectiveness. In this review article, we summarized the recent progress in various nanoformulations for cancer therapy, with special emphasis on tumour microenvironment stimuli-responsive ones. Numerous tumour microenvironment modulation strategies with promising cancer therapeutic efficacy have also been highlighted. Future challenges and opportunities of design consideration are also discussed in details. We believe that these tumour microenvironment modulation strategies offer a good chance for the practical translation of nanoparticle formulas into clinic.

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“…In addition to RBCs, many other cell types have been used to source the membrane for coating, and each carries with it unique benefits. Cancer cell membrane is lowly immunogenic and can take advantage of the homotypic targeting effect in which the particles have high affinity towards the same cells from which the membrane was derived [219,223,224]. White blood cell membrane can bestow cancer targeting properties and additionally has been shown to help particles traverse endothelium [225–227].…”

Section: Cell Membrane-based Nanostructuresmentioning

confidence: 99%

Cell membrane-derived nanomaterials for biomedical applications

et al. 2017

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The continued evolution of biomedical nanotechnology has enabled clinicians to better detect, prevent, manage, and treat human disease. In order to further push the limits of nanoparticle performance and functionality, there has recently been a paradigm shift towards biomimetic design strategies. By taking inspiration from nature, the goal is to create next-generation nanoparticle platforms that can more effectively navigate and interact with the incredibly complex biological systems that exist within the body. Of great interest are cellular membranes, which play essential roles in biointerfacing, self-identification, signal transduction, and compartmentalization. In this review, we explore the major ways in which researchers have directly leveraged cell membrane-derived biomaterials for the fabrication of novel nanotherapeutics and nanodiagnostics. Such emerging technologies have the potential to significantly advance the field of nanomedicine, helping to improve upon traditional modalities while also enabling novel applications.

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Cancer‐Cell‐Biomimetic Nanoparticles for Targeted Therapy of Homotypic Tumors

Cited by 527 publications

References 37 publications

Magnetic Mesoporous Silica Nanoparticles Cloaked by Red Blood Cell Membranes: Applications in Cancer Therapy

Magnetic Mesoporous Silica Nanoparticles Cloaked by Red Blood Cell Membranes: Applications in Cancer Therapy

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

Cell membrane-derived nanomaterials for biomedical applications

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