Cancer Cell Membrane-Biomimetic Nanoplatform for Enhanced Sonodynamic Therapy on Breast Cancer via Autophagy Regulation Strategy

Feng, Qianhua; Yang, Xuemei; Hao, Yanling; Wang, Ning; Feng, Xuebing; Hou, Lin; Zhang, Zhenzhong

doi:10.1021/acsami.9b10948

Cited by 121 publications

(90 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For breast cancer, a biomimetic nanoplatform exhibited capability in restoring cells' sensitivity to SDT via autophagy inhibition. This design "based on hollow mesoporous titanium dioxide nanoparticles by HCQ loading and cancer cell membrane coating" (Qianhua Feng et al, 2019). For the chemotherapy of glioma, blood brain barrier and autophagy-induced chemo-resistance are two limitation factors.…”

Section: The Challenge and Development Of Targeting Cytoprotective Aumentioning

confidence: 99%

Combination of an Autophagy Inducer and an Autophagy Inhibitor: A Smarter Strategy Emerging in Cancer Therapy

Liu

Zhang

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

Autophagy is considered a cytoprotective function in cancer therapy under certain conditions and is a drug resistance mechanism that represents a clinical obstacle to successful cancer treatment and leads to poor prognosis in cancer patients. Because certain clinical drugs and agents in development have cytoprotective autophagy effects, targeting autophagic pathways has emerged as a potential smarter strategy for cancer therapy. Multiple preclinical and clinical studies have demonstrated that autophagy inhibition augments the efficacy of anticancer agents in various cancers. Autophagy inhibitors, such as chloroquine and hydroxychloroquine, have already been clinically approved, promoting drug combination treatment by targeting autophagic pathways as a means of discovering and developing more novel and more effective cancer therapeutic approaches. We summarize current studies that focus on the antitumor efficiency of agents that induce cytoprotective autophagy combined with autophagy inhibitors. Furthermore, we discuss the challenge and development of targeting cytoprotective autophagy as a cancer therapeutic approach in clinical application. Thus, we need to facilitate the exploitation of appropriate autophagy inhibitors and coadministration delivery system to cooperate with anticancer drugs. This review aims to note optimal combination strategies by modulating autophagy for therapeutic advantage to overcome drug resistance and enhance the effect of antitumor therapies on cancer patients.

show abstract

Section: The Challenge and Development Of Targeting Cytoprotective Aumentioning

confidence: 99%

Combination of an Autophagy Inducer and an Autophagy Inhibitor: A Smarter Strategy Emerging in Cancer Therapy

Liu

Zhang

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…found that a low‐dose of SDT could induce autophagy and showed resistance to SDT‐mediated apoptosis. [ 130 ] Taken this into account, it might be an excellent scheme to improve the SDT effect through an autophagy regulation strategy. In their study, they reported a biomimetic nanoplatform based on hollow mesoporous TiO 2 nanoparticles loaded with autophagy inhibitors (hydroxychloroquine sulfate, HCQ) and coated with MCF‐7 cancer cell membrane (Figure 20D,E).…”

Section: Sonodynamic Therapy Combined With Other Treatmentsmentioning

confidence: 99%

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

et al. 2020

View full text Add to dashboard Cite

Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such as deeper penetration depth, absence of phototoxicity, and fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks to the facile engineering nature of nanotechnology, numerous novel nanoplatforms are being applied in this emerging field to tackle these intrinsic barriers and achieve continuous innovations. In particular, the combination of SDT with other treatment strategies has demonstrated a superior efficacy in improving anticancer activity relative to that of monotherapies alone. Therefore, it is necessary to summarize the nanomaterial-assisted combinational sonodynamic cancer therapy applications. Herein, the design principles in achieving synergistic therapeutic effects based on nanomaterial engineering methods are highlighted. The ultimate goals are to stimulate the design of better-quality combined sonodynamic treatment schemes and provide innovative ideas for the perspectives of SDT in promoting its future transformation to clinical application.

show abstract

“…As shown in Fig. 13, Feng et al reported a cancer cell membrane coated and autophagy inhibitor (hydroxychloroquine sulphate, HCQ) loaded nanoplatform (HMTNP) [119]. Due to the functionalization of biomimetic surface, CCM-HMTNPs/HCQ can escape from macrophage phagocytosis through homologous targeting ability, and actively identify and locate tumors.…”

Section: Tio2 Nanostructures-based Sonosensitizersmentioning

confidence: 99%

“…a) Formulation of CCM-HMTNPs/HCQ and (b) vessel normalization effect of HCQ for enhancing the oxygen-dependent SDT treatment (reproduced with permission from Ref [119],. © American Chemical Society 2019).…”

mentioning

confidence: 99%

Recent advances in nanomaterials for sonodynamic therapy

et al. 2020

View full text Add to dashboard Cite

Sonodynamic therapy (SDT), as a novel non-invasive strategy for eliminating tumor, has the advantages of deeper tissue penetration, fewer side effects, and better patient compliance, compared with photodynamic therapy (PDT). In SDT, ultrasound was used to activate sonosensitizer to produce cytotoxic reactive oxygen species (ROS), induce the collapse of vacuoles in solution, and bring about irreversible damage to cancer cells. In recent years, much effort has been devoted to developing highly efficient sonosensitizers which can efficiently generate ROS. However, the traditional organic sonosensitizers, such as porphyrins, hypericin, and curcumins, suffer from complex synthesis, poor water solubility, and low tumor targeting efficacy which limit the benefits of SDT. In contrast, inorganic sonosensitizers show good in vivo stability, controllable physicochemical properties, ease of achieving multifunctionality, and high tumor targeting, which greatly expanded their application in SDT. In this review, we systematically summarize the nanomaterials which act as the carrier of molecular sonosensitizers, and directly produce ROS under ultrasound. Moreover, the prospects of inorganic nanomaterials for SDT application are also discussed.

show abstract

Cancer Cell Membrane-Biomimetic Nanoplatform for Enhanced Sonodynamic Therapy on Breast Cancer via Autophagy Regulation Strategy

Cited by 121 publications

References 40 publications

Combination of an Autophagy Inducer and an Autophagy Inhibitor: A Smarter Strategy Emerging in Cancer Therapy

Combination of an Autophagy Inducer and an Autophagy Inhibitor: A Smarter Strategy Emerging in Cancer Therapy

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Recent advances in nanomaterials for sonodynamic therapy

Contact Info

Product

Resources

About