Cancer cell membrane-coated C-TiO2 hollow nanoshells for combined sonodynamic and hypoxia-activated chemotherapy

Ning, Shipeng; Tang, Weiwei; Guo, Qinglong; Lyu, Meng; Huang, Chunyu; Zhang, Wei; Qian, Haisheng; Yao, Xiaxi; Wang, Xianwen

doi:10.1016/j.actbio.2022.08.067

Cited by 67 publications

(39 citation statements)

References 64 publications

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“…And these keywords with an ongoing burst until now deserve special attention because they may have great potential to continue to be hot topics in the near future ( Wu et al, 2021a ). Taken together with keywords co-occurrence and burst analysis, with the exception of nanomaterials-related studies including nanoparticles, mesoporous silica nanoparticles, nanosheets, liposomes, microbubble and TiO 2 nanoparticle, the following research directions such as immunogenic cell death ( Zheng et al, 2021 ; Zheng et al, 2022 ), metal-organic framework ( Pan et al, 2018b ), photothermal therapy ( Liang et al, 2019 ), hypoxia ( Chen et al, 2017 ; Zhu et al, 2018 ), tumor microenvironment ( An et al, 2020 ), chemodynamic therapy ( Bai et al, 2020 ), combination therapy ( Ning et al, 2022 ), tumor resistance ( Guan et al, 2022 ), intensity focused ultrasound ( Ohmura et al, 2011 ; Roberts et al, 2022 ), drug delivery ( Ren et al, 2022 ), and Staphylococcus aureus ( Yu et al, 2021 ) also deserve further attention and may continue to explode in the future. Given space limitations, we only discussed several directions such as immunogenic cell death (ICD), hypoxia and Staphylococcus aureus as follows.…”

Section: Discussionmentioning

confidence: 99%

Mapping knowledge landscapes and emerging trends of sonodynamic therapy: A bibliometric and visualized study

Cheng

Shen

et al. 2023

Front. Pharmacol.

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Background: Ultrasound-triggered sonodynamic therapy (SDT), as a non-invasive approach, has attracted considerable attention in a wide variety of malignant tumors and other diseases. Over the past 2 decades, the number of scientific publications on SDT has increased rapidly. However, there is still a lack of one comprehensive report that summarizes the global research trends and knowledge landscapes in the field of SDT in detail. Thus, we performed a bibliometric analysis on SDT from 2000 to 2021 to track the current hotspots and highlight future directions.Methods: We collected publications on SDT research from the Web of Science Core Collection database. The annual number of publications and citations, major contributors, popular journals, international collaborations, co-cited references and co-occurrence keywords were analyzed and visualized with CiteSpace, VOSviewer, and R-bibliometrix.Results: A total of 701 publications were included. The annual publication output increased from 5 in 2000 to 175 in 2021, and the average growth rate was 18.4%. China was the most productive country with 463 documents (66.05%), and Harbin Medical University was the most prolific institution (N = 73). Ultrasound in Medicine and Biology published the most papers related to SDT. Materials Science, and Chemistry were the research areas receiving the most interest. All the keywords were divided into four different clusters including studies on mechanisms, studies on drug delivery and nanoparticles, studies on cancer therapy, as well as studies on ultrasound and sonosensitizers. In addition to nanomaterials-related studies including nanoparticles, mesoporous silica nanoparticles, nanosheets, liposomes, microbubble and TiO2 nanoparticle, the following research directions such as immunogenic cell death, metal-organic framework, photothermal therapy, hypoxia, tumor microenvironment, chemodynamic therapy, combination therapy, tumor resistance, intensity focused ultrasound, drug delivery, and Staphylococcus aureus also deserve further attention and may continue to explode in the future.Conclusion: SDT has a bright future in the field of cancer treatment, and nanomaterials have increasingly influenced the SDT field with the development of nano-technology. Overall, this comprehensive bibliometric study was the first attempt to analyze the field of SDT, which could provide valuable references for later researchers to better understand the global research trends, hotspots and frontiers in this domain.

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Section: Discussionmentioning

confidence: 99%

Mapping knowledge landscapes and emerging trends of sonodynamic therapy: A bibliometric and visualized study

Cheng

Shen

et al. 2023

Front. Pharmacol.

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“…This could be achieved through rationally designing and combining several functional moieties within a single nanocarrier to formulate a multistimuli-responsive carrier . This carrier could target and release drugs on-demand to the desired tumor site in the body . The design of the multistimuli-response with targeting and on-demand release ability takes place via the shrinking or expansion in the sizes of nanocarriers, altering of surface charges, and regulation of other physiochemical properties …”

Section: Introductionmentioning

confidence: 99%

Dual pH-/Thermoresponsive Shell-Cross-Linked Magnetic Mesoporous Nanospheres for Doxorubicin Delivery and In Vitro/In Vivo Cancer Treatment

Mdlovu

Juang

Lin

et al. 2023

ACS Appl. Nano Mater.

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Engineered nanomaterials have been explored for chemotherapeutic drug delivery systems toward improved therapeutic effects. In this study, magnetic nanospheres consisting of MCM-41 formed onto iron oxide nanoparticles (MIO NPs) to form MMCM with cross-linked shells of Pluronic F127 (PF) and polyethylenimine (PEI) to form (MMFPEI NSs) nanospheres were synthesized. These nanospheres were loaded with doxorubicin (DOX) anticancer drug for drug-controlled release and therapeutic efficacy evaluations in mice. Nanoscale/core–shell MMFPEI NSs were successfully formed as indicated by the TEM analysis. The microstructural analysis revealed the presence of three peaks corresponding to indexed reflections (100), (110), and (200) of MCM-41. The MMFPEI NSs displayed a pH-/thermoresponsive drug release of 84.76% under a simulated tumor microenvironment. Principally, the Peppas-Sahlin, Weibull, and Korsmeyer-Peppas models, respectively, provided the best fitting for our drug delivery system with the highest correlation degree of coefficient (R 2) and the lowest AIC. The kinetics studies for diffusion exponent indicated that the MMFPEI NSs possessed predominantly Fickian diffusion behavior. The growth retardation results of HepG2 cells showed that when compared with free DOX, the MMFPEI-DOX NSs exhibited statistically significant stronger cell inhibition efficacy at the dosages of 2, 5, and 10 μg/mL after 24 and 48 h of incubation. According to the in vivo therapeutic assessments, the tumor sizes upon inoculation with PBS, MMFPEI NSs, PBS-DOX, and MMFPEI-DOX NSs were 1302.7, 1165.6, 830.9, and 382.6 mm3, respectively. Therefore, the formulated nanospheres have great probable for drug delivery in cancer therapy to overcome the limits of traditional chemotherapy.

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Section: Introductionmentioning

confidence: 99%

“…[24] Additionally, the constructed system of NPs coated with the TCL could target tumors specifically and further enhance the personalized immunotherapy via the whole tumor antigen-mediated-activation of cytotoxic T cells. [21,25,26] Based on the whole tumor cells, cancer vaccines played as a promising avenue for tumor personalized immunotherapy. [27,28] The TCLs from autologous tumor cell source, contained patientspecific tumor antigens, which achieved personalized immunotherapy, and do not need to get extra bio sample acquisition for comparative sequencing to redesign and reproduce targeted tumor prioritization.…”

Section: Introductionmentioning

confidence: 99%

Personalized Bacteria Loaded with Autoantigens for the Enhancement of Tumor Immunotherapy

Wang

Chen

et al. 2023

Adv Healthcare Materials

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Currently, tumor immunotherapy is becoming a new revolution in tumor treatment. Generated from tumor cell lysate (TCL) or irradiated tumor cells, the whole tumor antigen‐based vaccines have the possibility to enhance antitumor immune response without survival from immune surveillance in personalized immunotherapy. Here, polydopamine nanoparticles (PDA NPs) after self‐polymerization are covalently coated with TCL to form PDA@CL. Engineered Salmonella (EnS) wrapped with PDA@CL (EnS@PDA@CL) is targeted the localization of the tumor site by intravenous administration. EnS@PDA@CL delivered autologous antigen‐containing nanoparticles to tumor hypoxia regions through blood circulation. The PDA@CL particles promote the maturation of dendritic cells (DCs), thus eliciting the infiltration of whole tumor antigens specific cytotoxic T lymphocytes, significantly triggering antitumor immunity. The tumor regression in the Panc02 mice confirms the therapeutic potential of EnS@PDA@CL in clinical personalized immunotherapy.

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Cancer cell membrane-coated C-TiO2 hollow nanoshells for combined sonodynamic and hypoxia-activated chemotherapy

Cited by 67 publications

References 64 publications

Mapping knowledge landscapes and emerging trends of sonodynamic therapy: A bibliometric and visualized study

Mapping knowledge landscapes and emerging trends of sonodynamic therapy: A bibliometric and visualized study

Dual pH-/Thermoresponsive Shell-Cross-Linked Magnetic Mesoporous Nanospheres for Doxorubicin Delivery and In Vitro/In Vivo Cancer Treatment

Personalized Bacteria Loaded with Autoantigens for the Enhancement of Tumor Immunotherapy

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