Cancer Chemoprevention by Carotenoids

Tanaka, Takuji; Shnimizu, Masahito; Moriwaki, Hisataka

doi:10.3390/molecules17033202

Cited by 501 publications

(307 citation statements)

References 234 publications

(304 reference statements)

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“…As antioxidants, carotenoids may reduce oxidative damage due to environmental exposures and by normal metabolic processes in the body. [9][10][11] Reactive oxygen species damage genetic material and cellular machinery, increasing the likelihood of abnormal cell growth and impaired communication. Carotenoids also have antiproliferative properties, inhibiting cell growth and angiogenesis and increasing cell differentiation and apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…Carotenoids absorb free radicals, protecting cells from oxidative damage, and may also inhibit cell growth and angiogenesis, increasing apoptosis and the immune response. 1,[9][10][11][12][13][14] To our knowledge, no previous prospective studies have assessed adolescent dietary carotenoid intake in relation to BBD risk in young women. We examined this association in the Growing Up Today Study (GUTS), a prospective cohort initiated in childhood.…”

mentioning

confidence: 99%

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Adolescent Carotenoid Intake and Benign Breast Disease

et al. 2014

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BACKGROUND: Carotenoids may reduce risk of benign breast disease (BBD), an independent risk factor for breast cancer, through antioxidative or antiproliferative mechanisms. Exposure to carotenoids may be most important during adolescence when breast tissue is still developing. We examined adolescent carotenoid intake in relation to BBD in young women. METHODS: In 6593 adolescent girls in the prospective Growing Up Today Study cohort, intakes of α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin, and lycopene were assessed by using the means from food-frequency questionnaires in 1996, 1997, and 1998. Girls reported biopsy-confirmed BBD on questionnaires in 2005, 2007, and 2010 (n = 122). We conducted logistic regression of energy-adjusted carotenoid intakes in relation to BBD, adjusted for age, family history of breast cancer or BBD, age at menarche, nulliparity, alcohol intake, BMI, and physical activity. RESULTS: Mean (SD) age at baseline was 12.0 (1.6) years. β-Carotene intake was inversely associated with BBD; comparing the highest to lowest quartile, the multivariate-adjusted odds ratio was 0.58 (95% confidence interval: 0.34–1.00; P-trend = .03). α-Carotene and lutein/zeaxanthin were also inversely associated with BBD, but the associations were not statistically significant. CONCLUSIONS: Adolescent carotenoid intake may be associated with lower BBD risk; these findings warrant further study.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Adolescent Carotenoid Intake and Benign Breast Disease

et al. 2014

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“…Thus, inhibiting this vicious cycle has the potential to delay, prevent the progression of and/or treat these diseases. However, the adverse effects of the current anti-inflammatory drugs [82,83] and the failure of exogenous antioxidant administration [29] should encourage scientists to develop new therapeutic alternatives.…”

Section: Chemopreventionmentioning

confidence: 99%

“…The biological basis for the concept of oral premalignancy has been established by carcinogenesis studies [7,[28][29][30].…”

Section: Leukoplakiamentioning

confidence: 99%

Preneoplasia and carcinogenesis of the oral cavity

Watanabe¹,

Ohkubo²,

Shimizu³

et al. 2015

Oncol Discov

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Oral cancer, ranking sixth in the cancer incidence worldwide, is one of the most common neoplasms. Preneoplastic or premalignant (precancerous) lesions are lesions that can potentially transform into malignancy in a variety of tissues, including the oral cavity. Such oral lesions may be caused by tobacco use, exposure to the human papillomavirus and chewing of the betel nut. These substances contain carcinogens and/or tumor promoters. The mucosa of the oral cavity is covered with squamous epithelium and is relatively resistant to injury. However, exposure to these substances can cause the mucosa to undergo changes. The changes are usually initiated by a leukoplakic patch. While some leukoplakic patches recover and resolve, others progress to squamous cell carcinoma with or without invasion. Other premalignant lesions include oral submucous fibrosis, which is a potentially malignant condition caused by the abuse of the betel nut. Understanding the histology, premalignant states and molecular mechanisms of oral carcinogenesis may facilitate the development of novel strategies for the prevention and treatment of oral cancer. In addition, early detection is of critical importance to improve the survival rates of patients with oral cancer. In this review, we will summarize these aspects of oral cancer development, beginning from the histology of the oral cavity.

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“…Preclinical studies have shown that some carotenoids have potent antitumor effects both in vitro and in vivo models. Since chemoprevention is one of the most important strategies in the control of cancer development, molecular mechanismbased cancer chemoprevention using carotenoids seems to be an attractive approach (Tanaka et al, 2012).…”

Section: Anticancer Mechanismmentioning

confidence: 99%

Anti-Cancer Mechanism and Possibility of Nano-Suspension Formulation for a Marine Algae Product Fucoxanthin

Srinivasan¹,

Francis²

2013

Asian Pacific Journal of Cancer Prevention

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Marine algae contain a wide variety of bioactive compounds; many of them have commercial applications in pharmaceutical, medical, cosmetic, nutraceutical, food and agricultural industries. Natural antioxidants, found in many algae play an important role against various diseases through protection of cells from oxidative AbstractRecently, use of natural products available from marine sources, and especially algae products, are receiving more attention. Scientific evidence for claimed nutraceutical and therapeutical effects of one such marine algae product, fucoxanthin, is discussed in this paper with a summary of the currently available literature regarding its antioxidant, anti-obesity and anticancer activities. It is safe for use in humans, but as it has poor solubility a nano-suspension mode of delivery may be adopted to improve efficacy of supplments. We conclude from ourliterature review that the marine algae product fucoxanthin has significant antioxidant, anti-obesity and anticancer activity with established mechanisms of action.

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Cancer Chemoprevention by Carotenoids

Cited by 501 publications

References 234 publications

Adolescent Carotenoid Intake and Benign Breast Disease

Adolescent Carotenoid Intake and Benign Breast Disease

Preneoplasia and carcinogenesis of the oral cavity

Anti-Cancer Mechanism and Possibility of Nano-Suspension Formulation for a Marine Algae Product Fucoxanthin

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