Cancer of the tongue in young persons

Goyanes, Alfredo Die; Frazell, Edgar L.

doi:10.1002/jso.2930030408

Cited by 26 publications

(16 citation statements)

References 5 publications

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“…The male–female ratio in the total cases treated during the same period was 1.39:1. Some previous studies have suggested that there is a predominance of females in the younger age groups (7, 24), but most have reported a similar higher number of males (2, 3, 15, 16, 25, 26). Analysis by site showed that 54.3% of cancers arose on the tongue in young patients, compared with 30.9% in older patients, supporting previous studies suggesting that tongue may be more commonly affected in younger patients (reviewed in 15).…”

Section: Discussionmentioning

confidence: 95%

Clinico‐pathological features of squamous cell carcinoma of the oral cavity in patients <40 years of age

Sasaki

Moles

Imai

et al. 2005

J Oral Pathology Medicine

104

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Section: Discussionmentioning

confidence: 95%

Clinico‐pathological features of squamous cell carcinoma of the oral cavity in patients <40 years of age

Sasaki

Moles

Imai

et al. 2005

J Oral Pathology Medicine

104

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“…Eleven studies reported on 94 patients with SCC of the anterior tongue whose TNM stage, treatment, and disease-related outcome at 2 years minimum were known. [4][5][6][7][8][9][10][11][12][13][14] Table 1 provides an overview of the patients and the studies cited.…”

Section: Methodsmentioning

confidence: 99%

Cancer of the tongue in patients less than forty

et al. 2000

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Introduction It is the opinion of many surgeons that the biologic potential of cancer that develops in young people is different compared with older patients. Prior reports on small series of patients addressing this issue have inadequate statistical power to resolve the question. Methods By use of the techniques of meta‐analysis, patients less than 40 years old who had undergone treatment of squamous cell carcinoma (SCC) of the oral tongue were examined. Twenty‐eight patients who were encountered in the Department of Otolaryngology, University of Pittsburgh School of Medicine, and 94 patients were identified in the literature for a total of 122 patients <40 years old. A control group of 150 patients, aged 40 years and older treated for SCC of the oral tongue between 1982 and 1994 was identified. Results Three‐year disease‐free survival in the group of patients aged less than 40 was 53.3% compared with 3‐year disease free survivorship of 55.0% in the older cohort of patients. Conclusion These data strongly suggest that the outcomes of treatment for SCC of the oral tongue in young patients are similar compared with patients older than 40 with similar extent of disease. © 2000 John Wiley & Sons, Inc. Head Neck 22: 297–302, 2000.

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“…Prognosis varies from excellent to poor, reflecting the biases and difficulties in reporting small retrospective studies (Table 1). 5,[12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] In a summary of 14 studies published in the English-speaking literature between 1968 and 1993 involving oral tongue SCC in patients aged less than 40 years old, 152 patients were identified. 26 In 11 of these 14 studies, information regarding loco-regional failure was available, revealing that 57% failed above the clavicles and that 71 (47%) died from their disease.…”

Section: Discussionmentioning

confidence: 99%

Tongue cancer in younger patients

Veness

1999

Australasian Radiology

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Tongue cancer involving the anterior tongue often presents at an early stage. The aetiology is strongly associated with smoking and alcohol abuse similar to other squamous cell carcinomas (SCC) of the head and neck (HN). Surgery and radiotherapy, either alone or together, offer the prospect of cure in the majority of patients. However, there remains a group of younger patients less than 40 years old for whom outcome is often poor. Presented here is the case of a 24-year-old woman who developed SCC of the anterior tongue. Despite treatment, loco-regional relapse occurred resulting in death. The literature identifies a distinct subgroup of younger patients who develop HN SCC, particularly of the oral cavity. The aetiology remains unclear. Recent studies have looked at the prognostic significance of various new non-clinico-pathological markers in HN SCC (including p53 tumour suppressor gene, cyclin D1 protein, Ki 67 antigen and tumour angiogenesis). The majority of these studies, as expected, have involved the typical HN patient (male, aged > 60 years old). However, the relevance of these studies is of likely importance to all patients diagnosed with HN SCC. The recent use of these non-clinical-pathological markers in HN SCC, including reference to such studies in younger patients, is discussed. The English literature during the past 30 years is reviewed with reference to the diagnosis of tongue SCC in younger patients.

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Cancer of the tongue in young persons

Cited by 26 publications

References 5 publications

Clinico‐pathological features of squamous cell carcinoma of the oral cavity in patients <40 years of age

Clinico‐pathological features of squamous cell carcinoma of the oral cavity in patients <40 years of age

Cancer of the tongue in patients less than forty

Tongue cancer in younger patients

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