Candidal carriage, isolation and species variation in patients undergoing radiotherapy and chemotherapy for head and neck tumours

Bakki, Shoba Rani; Kantheti, Lalith Prakash Chandra; Kuruba, Kiran Kumar; Poosarla, Chandrasekhar; Baddam, Venkat Ramana Reddy; Mulakaluri, Raja Rajeswari

doi:10.4103/2277-8632.128427

Cited by 5 publications

(3 citation statements)

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“…Regarding the prevalence of species, our findings corroborate studies that showed Candida albicans as the primary etiological agent of denture stomatitis [2, 21, 27, 36, 47–49]. …”

Section: Discussionsupporting

confidence: 89%

Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial

Pina

Lia

Berretta

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Our hypothesis tested the efficacy and safety of a mucoadhesive oral gel formulation of Brazilian propolis extract compared to miconazole oral gel for the treatment of denture stomatitis due to Candida spp. infection in older adults. Forty patients were randomly allocated in a noninferiority clinical trial into two groups. The control group (MIC) received 20 mg/g miconazole oral gel and the study group (PROP) received mucoadhesive formulation containing standardized extract of 2% (20 mg/g) propolis (EPP-AF®) during 14 days. Patients were examined on days 1, 7, and 14. The Newton's score was used to classify the severity of denture stomatitis. The colony forming unity count (CFU/mL) was quantified and identified (CHROMagar Candida®) before and after the treatment. Baseline characteristics did not differ between groups. Both treatments reduced Newton's score (P < 0.0001), indicating a clinical improvement of the symptoms of candidiasis with a clinical cure rate of 70%. The microbiological cure with significant reduction in fungal burden on T14 was 70% in the miconazole group and 25% in the EPP-AF group. The EPP-AF appears to be noninferior to miconazole considering the clinical cure rate and could be recommended as an alternative treatment in older patients.

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“…Regarding the prevalence of species, our findings corroborate studies that showed Candida albicans as the primary etiological agent of denture stomatitis [2, 21, 27, 36, 47–49]. …”

Section: Discussionsupporting

confidence: 89%

Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial

Pina

Lia

Berretta

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…Overall in swab samples taken after two weeks of radiation, 38% of fungal species were non-albicans, 44% albicans, and 20% were negative for any fungal growth. These results were in accordance with other similar studies as the radiotherapy progresses, there is an increase in the incidence of non-albicans species 16,17 .…”

Section: Discussionsupporting

confidence: 93%

Prevalence of different fungal species in Saliva and Swab samples of patients undergoing Radiotherapy for Oral Cancer

Putta¹,

Natarajan²,

Beeraka³

et al. 2021

J. Pure Appl. Microbiol.

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Oral cancer is one of the leading causes of morbidity and mortality globally. There is a lack of studies on the growth of different Candida species in swab pre and post-radiotherapy. Hence, this study aimed to determine different Candida species in the oral cavity of patients who undergo radiotherapy. The study included 50 patients with oral cancer scheduled to undergo radiotherapy. Both saliva and swab samples were collected from all the patients before and after two- and six weeks of starting the radiotherapy. Similar inoculation was performed using the salivary swabs and incubated aerobically at 37°C for 48h. After 48h, culture plates were removed from the incubator and observed for the growth of different fungal species based on the color of the colonies. The culture of samples from patients with oral cancer resulted in the growth of 68% of Candida species in saliva and 44% in swab before initiating radiation. Unlike baseline findings, Candida albicans were identified in a higher number in swab samples (44%) than saliva (24%) post two weeks of radiotherapy. All saliva samples were positive to candida species, in which Candida albicans shows high prevalence (24%). After six weeks of radiotherapy, in the swab, 30% of samples were positive for Candida albicans, and 18% of samples were positive for non-albicans species. Before radiotherapy, at two weeks and six weeks of radiotherapy, saliva samples showed a higher prevalence of Candidal species compared to swab samples. The combination of other Candida species was also higher in saliva samples compared to swab samples during radiotherapy.

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“…The occurrence of Candida sp. varied from 20 to 70% in cases undergoing RT, and some studies suggest that the prevalence of other species besides C. albicans is higher in irradiated patients 17,18 , while in our study we observed a significant decrease in C. non albicans in the RT group as compared to that in control.…”

Section: Discussioncontrasting

confidence: 56%

Effect of Chemo-radiotherapy on Salivary Flora of Oral Cancer Patients

Maurya¹,

Rastogi²,

Sen³

et al. 2021

J. Pure Appl. Microbiol.

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Management of cancers of oral cancers has remained a major challenge in India and globally. Radiotherapy and chemotherapy are mostly employed for treatment which inflicts changes in oral mucosa and makes it vulnerable for bacterial colonization and eventual infections. This study aims at evaluating the changes in oropharyngeal flora (bacteria and yeast) in oral cancer patients treated by a combination of chemo-radiotherapy with the control groups comprising of non-cancerous patients living in the same environment. This prospective evaluation included Seventy seven patients with oral squamous cell carcinomas in the study group. Whereas the control group comprised of twenty five non-cancerous patients. Saliva samples were collected from patients with oral carcinomas and those of the control group for bacteriological examination, and were transported within 2 hours to the laboratory and immediately inoculated and incubated. The oral microflora samples collected were evaluated for the presence of bacteria in saliva in both study and control group of patients. We evaluated the change in salivary oral flora during chemo-radiotherapy treatment. A statistically significant increase in growth of normal as well as abnormal oral flora was observed post-radiation. Escherichia coli showed a significant decrease in post-RT and also near to significant in control. Various changes in salivary oral flora were observed during the course of chemo-radiotherapy in study and controls groups. This shows that there are some sensitive spots in the oral cavity where the occurrence of oral cancer is more.

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Candidal carriage, isolation and species variation in patients undergoing radiotherapy and chemotherapy for head and neck tumours

Cited by 5 publications

References 0 publications

Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial

Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial

Prevalence of different fungal species in Saliva and Swab samples of patients undergoing Radiotherapy for Oral Cancer

Effect of Chemo-radiotherapy on Salivary Flora of Oral Cancer Patients

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