Canine circoviral hemorrhagic enteritis in a dog in Connecticut

Kruiningen, Herbert J. Van; Heishima, Mizuki; Kerr, Kirklyn M.; Garmendia, Antonio E.; Helal, Zeinab H.; Smyth, Joan A.

doi:10.1177/1040638719863102

Cited by 14 publications

(20 citation statements)

References 13 publications

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“…The relationship between ElkCV and the lesions in this case remains unclear. In dogs, there has been a proposed association between hemorrhagic gastroenteritis with vasculitis and canine circovirus 36 ; however, a case-control study also identified the virus in healthy control dogs, suggesting that infection is widespread 37 . Similarly, PCV1 is not known to cause disease in pigs and many pigs infected with PCV2 do not develop severe lesions.…”

Section: Resultsmentioning

confidence: 99%

Discovery and comparative genomic analysis of elk circovirus (ElkCV), a novel circovirus species and the first reported from a cervid host

Fisher¹,

Harrison²,

Nebroski³

et al. 2020

Sci Rep

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The complete genome sequence of a novel circovirus (elk circovirus (ElkCV) Banff/2019) was determined via high throughput sequencing of liver tissue from a euthanized Rocky Mountain elk (Cervus canadensis nelsoni) from Alberta, Canada. The genome is circular and 1,787 nucleotides long, with two major ORFs encoding predicted proteins. Comparative genomic analysis to 4,164 publicly available complete and near complete circovirus genomes showed that ElkCV shares approximately 65% pairwise genome-wide nucleotide identity with the most closely related circovirus species, porcine circoviruses (PCV) 1 and 2 and bat-associated circovirus (BatACV) 11. ElkCV features a stem-loop within the origin of replication region characteristic of circoviruses. However, it differs from those found in PCV1, PCV2 and BatACV11 since it has a longer stem and contains hexamer repeats that overlap the stem in opposing orientations. Interestingly, stem-loop structures of similar length featuring repeats in a similar position and orientation are also seen in some avian circoviruses. Based on the demarcation threshold established by the International Committee on Taxonomy of Viruses (ICTV) for members of Circoviridae (80% pairwise genome-wide nucleotide identity), ElkCV represents a novel species and is the first complete circovirus genome reported from a cervid host.

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Section: Resultsmentioning

confidence: 99%

Discovery and comparative genomic analysis of elk circovirus (ElkCV), a novel circovirus species and the first reported from a cervid host

Fisher¹,

Harrison²,

Nebroski³

et al. 2020

Sci Rep

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“…Subsequently, CanineCV was identified in Italy and was thought to be the causative agent of canine necrotizing vasculitis and lymph node granuloma, which can cause vomiting and hemorrhagic diarrhea in dogs [ 2 , 3 ]. To date, CanineCV has been reported in several countries, indicating that the virus has spread worldwide [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. The genome of CanineCV is approximately 2063–2064 nt in size and primarily contains three open reading frames (ORFs).…”

Section: Introductionmentioning

confidence: 99%

Canine Circovirus Suppresses the Type I Interferon Response and Protein Expression but Promotes CPV-2 Replication

Hao

Chen

et al. 2022

IJMS

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Canine circovirus (CanineCV) is an emerging virus in canines. Since the first strain of CanineCV was reported in 2012, CanineCV infection has shown a trend toward becoming a global epidemic. CanineCV infection often occurs with coinfection with other pathogens that may aggravate the symptoms of disease in affected dogs. Currently, CanineCV has not been successfully isolated by laboratories, resulting in a lack of clarity regarding its physicochemical properties, replication process, and pathogenic characteristics. To address this knowledge gap, the following results were obtained in this study. First, a CanineCV strain was rescued in F81 cells using infectious clone plasmids. Second, the Rep protein produced by the viral packaging rescue process was found to be associated with cytopathic effects. Additionally, the Rep protein and CanineCV inhibited the activation of the type I interferon (IFN-I) promoter, blocking subsequent expression of interferon-stimulated genes (ISGs). Furthermore, Rep was found to broadly inhibit host protein expression. We speculate that in CanineCV and canine parvovirus type 2 (CPV-2) coinfection cases, CanineCV promotes CPV-2 replication by inducing immunosuppression, which may increase the severity of clinical symptoms.

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“…Some reports suggest that CanineCV might cause haemorrhagic diarrhoea in dogs. By PCR, CanineCV has been detected in the feces from 14 of 204 healthy dogs (6.9%) and 19 of 168 dogs with diarrhea (11.3%) 2 , and also, this agent has been detected in sporadic cases of dogs with vasculitis, histiocytic inflammation, or a combination 11 , 12 . On the other hand, the virus has been already reported in different wildlife carnivorous from Europe, mainly in Wolves ( Canis lupus ), red foxes ( Vulpes vulpes ) and virus from those wild animals share a genome identity up to 80%, suggesting that wildlife and dogs can interchange related circoviruses and that CanineCV could possibly be transmitted from dogs to wild canids, or vice versa 13 – 16 .…”

Section: Introductionmentioning

confidence: 99%

First detection and full genomic analysis of Canine Circovirus in CPV-2 infected dogs in Colombia, South America

Giraldo-Ramirez

Rendón-Marín

Vargas-Bermúdez

et al. 2020

Sci Rep

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Canine Circovirus (CanineCV) is an emerging virus which since its first report in USA in 2012, it has been described worldwide. It was the second mammalian circovirus species identified in dogs and its role in canine enteritis is still being uncertain as much as its association in disease with the Canine Parvovirus-2 (CPV-2). Here, we aim to confirm for the first time the presence of CanineCV in Colombia and to develop phylogenetic evolutive analyses of CanineCV in CPV-2 positive animals. DNA from samples were extracted and PCR, full genome sequencing and phylogenetic analysis was performed to detect and characterize CanineCV. From a total of 30 CPV-2 positive samples, 16.6% (n = 5) were positives for CanineCV. Sequencing analysis of Colombian CanineCV wild-type strains displayed high identity to each other (99.5–99.7% nt; 99.7% aa). The full genome phylogenetic analysis confirmed that worldwide reported CanineCV strains were separated into four distinct genotypes in addition to a European origin of the South American CanineCV strains. This study demonstrated the importance of continue surveillance of emerging viruses in canine populations and confirm for the first time the circulation and origin of CanineCV in Colombia.

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Canine circoviral hemorrhagic enteritis in a dog in Connecticut

Cited by 14 publications

References 13 publications

Discovery and comparative genomic analysis of elk circovirus (ElkCV), a novel circovirus species and the first reported from a cervid host

Discovery and comparative genomic analysis of elk circovirus (ElkCV), a novel circovirus species and the first reported from a cervid host

Canine Circovirus Suppresses the Type I Interferon Response and Protein Expression but Promotes CPV-2 Replication

First detection and full genomic analysis of Canine Circovirus in CPV-2 infected dogs in Colombia, South America

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