Canine multicentric lymphoma 2: Comparison of response to two chemothera‐peutic protocols

Abstract

This paper describes the chemotherapeutic response of 90 cases of canine multicentric lymphoma. All the dogs were treated with a combination protocol using cyclophosphamide, vincristine and prednisolone. Forty‐seven dogs received additional intravenous cytosine arabinoside on the first four days of treatment. Eighty‐eight per cent of all cases had shown either a complete or partial response to this treatment at six weeks from the start of treatment and the overall mean survival time was 37 weeks (SD = 35.8). There was no significant difference in response or survival rates between the two treatment groups. The age and sex of the patient, the clinical stage of the disease and previous treatment with corticosteroids were all analysed to determine whether these parameters were of prognostic significance. Those dogs in clinical stages 4 and 5 carried a worse prognosis than those in stages 1 to 3. Previous treatment with corticosteroids adversely affected both tumour response and patient survival rates.

Feline extranodal lymphoma: response to chemotherapy and survival in 110 cats

“…The influence of pretreatment with corticosteroids before chemotherapy is an accepted negative prognostic factor in dogs with lymphoma (Dobson and Gorman 1994). A single study in cats (Simon and others 2008) did not find a significant effect of glucocorticoid pretreatment on response to treatment or survival in cats with lymphoma treated with combination chemotherapy, but numbers were small.…”

Cytosine arabinoside in addition to VCAA‐based protocols for the treatment of canine lymphoma with bone marrow involvement: does it make the difference?

“…The prognosis of canine lymphosarcoma (LSA) with bone marrow (BM) involvement (stage V) is usually worse than that of LSA of different clinical stages, with shorter median survival times in the first case 1–6 . The marrow infiltration itself plays a major adverse prognostic role, because traditional chemotherapeutic regimens, such as Cytoxan‐Oncovin‐Adriamycine‐Prednisone (COAP)‐based protocols, have not usually proved effective in wiping out neoplastic cells infiltrating the BM.…”

“…Of concern is the fact that chemotherapy is frequently complicated by systemic toxicity and severe myelosuppression and these adverse effects are more pronounced in the presence of marrow failure, leading to treatment delays and to drug dosage reductions, thereby reducing dose intensity and possibly affecting clinical outcome 1,7 . Treatment of stage V canine LSA with conventional chemotherapy is usually frustrating and associated with low probability of response and short duration of remission 1–6 . Thereby, alternative and more efficacious protocols are needed to improve outcome.…”

Multicentric lymphoma with metastasis in the central nervous system in a dog

“…However, there is no consensus regarding the optimal treatment in terms of efficacy, patient survival and toxicity (Rosenthal, 1990;Rosenthal and MacEwen, 1990;Dobson and Gorman, 1994). In veterinary patients with multicentric lymphoma, it can be used a relatively simple and low-cost protocol, as COP for example (Dobson and Gorman, 1994;Vail et al, 2001). This is well tolerated by the animals and results in a 60% to 70% complete response rate with a median survival of six to seven months (Cotter and Goldstein, 1983).…”