Cap Polyposis: Further Experience and Review

Ng, Kheng-Hong; Mathur, Pawan; Kumarasinghe, M. Priyanthi; Eu, Kong‐Weng; Seow‐Choen, Francis

doi:10.1007/s10350-004-0561-8

Cited by 53 publications

(41 citation statements)

References 18 publications

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“…Cap polyposis in humans is a rare disease characterized by the presence of polyps covered by a "cap" of granulation tissue [4,22,31]. Endoscopically, these polyps occur in multiples (1-100 polyps), and are small, reddish, and sessile.…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Study of Inflammatory Colorectal Polyps in Miniature Dachshunds

Ohmi

Tsukamoto

Ohno

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. Medical records of dogs with colorectal polyps were retrospectively reviewed, and clinical presentation of inflammatory colorectal polyps in miniature dachshunds was evaluated. Of 33 dogs found to have colorectal polyps, miniature dachshunds were markedly over-represented with 16 dogs (48%), of which 12 (75%) were found to have inflammatory polyps. Multiple polyps localized between the rectum and the descending colon was the most common finding in miniature dachshunds with inflammatory polyps. Twenty dogs (80%) out of 25 miniature dachshunds with inflammatory colorectal polyps responded to immunosuppressive therapy using prednisolone and cyclosporine. The results of this study indicate that miniature dachshunds are predisposed to develop inflammatory colorectal multiple polyps, for which immunosuppressive therapy may be a treatment option. Polyps are an abnormal growth of tissue arising from the mucosa, including neoplasms and inflammatory polyps. In dogs, colorectal polyps are relatively common in the gastrointestinal tract. These polyps can be single or multiple and are most often located in the distal rectum, causing the common clinical signs of hematochezia or tenesmus. In previous reports, many colorectal polyps in dogs were found to be derived from neoplasms, with adenomatous polyps and adenocarcinoma being most frequently represented [11,25,32,33]. Adenomatous polyps and adenocarcinoma are observed as solitary masses in the rectum, and most polyps appear as friable, lobulated, sessile, or pedunculated lesions on the mucosa. Surgical resection has been recommended in dogs as treatment for colorectal polyps [2,5,21]. Endoscopic treatment for adenomatous polyps [7,10] and piroxicam for tubulopapillary polyps [15] have been reported as alternative therapies for colorectal neoplasms. On the contrary, inflammatory colorectal polyps are rare, and few reports have described the clinical features of inflammatory colorectal polyps [33]. In humans, inflammatory colorectal polyps or polypoid lesions occur in association with inflammatory bowel disease (IBD) and other inflammatory diseases of the colon such as ischemic or infective colitis [3,17,24]. These masses form mainly due to extensive mucosal damage and healing processes, rather than infiltration of inflammatory cells. The polyps formed from infiltration of inflammatory cells, which could be termed "true" inflammatory polyps, seem to be relatively rare in humans.This study was conducted on the basis of two objectives. First, we retrospectively investigated dogs with colorectal polyps to characterize the prevalence and clinical features of the disease in Japan. Second, we reviewed the clinical presentation and treatment response of cases with inflammatory colorectal multiple polyps in miniature dachshunds, which were markedly over-represented in our study. MATERIALS AND METHODS Retrospective study of colorectal polyps in dogs:We reviewed the medical records of 33 dogs found to have colorectal polyps at the Veterinary Medical Center of the University of...

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Section: Discussionmentioning

confidence: 99%

A Retrospective Study of Inflammatory Colorectal Polyps in Miniature Dachshunds

Ohmi

Tsukamoto

Ohno

et al. 2012

The Journal of Veterinary Medical Science

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“…The avoidance of excessive straining during defecation has been reported as a successful treatment strategy in some cases (12). On the other hand, some authors reported that chronic straining or constipation was noted in only 7 out of the 11 patients (64%) (13). Also, the infant in our case report showed normal results in the anorectal motility study, no constipation, and no evidence of abnormal motility of the colon.…”

Section: Discussionmentioning

confidence: 99%

“…The author suggested that helper T-cell mediated inflammation is the mechanism for explaining the pharmacodynamic effectiveness of steroids or infliximab (14). However, there are many reports on the failure of steroids or infliximab (1315). Consequently, it is controversial whether steroids or infliximab should be administered uniformly.…”

Section: Discussionmentioning

confidence: 99%

A Case of Cap Polyposis with Epidermal Nevus in an Infant

et al. 2017

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Cap polyposis is extremely rare in children. We report a case of an 11-month-old male infant who visited our hospital because of rectal prolapse and small amount of hematochezia lasting several days. He also had an epidermal nevus in the sacral area. Colonoscopy showed erythematous, multilobulated, circumferential, polypoid lesions with mucoid discharge from the rectum. He was diagnosed with cap polyposis by endoscopy and histologic examination. He was treated with surgical resection, and was closely followed up. In the relevant literature, there is no report of cap polyposis in an infant. We report the first case of cap polyposis in the youngest infant.

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“…The common presentations are rectal bleeding, mucous diarrhea, or tenesmus. The number of polyps can vary from 1 to over 100 [32]. They are sessile or semipedunculated.…”

Section: Inflammatory Polyposismentioning

confidence: 99%

Cronkhite-Canada Syndrome: A Case Report and Literature Review of Gastrointestinal Polyposis Syndrome

Shen¹,

Husson²,

Lipshutz³

2014

CRCM

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Cronkhite-Canada syndrome (CCS) is a rare, non-inherited polyposis syndrome, characterized by diffuse gastrointestinal (GI) hamartomatous polyposis with unique dermatologic changes including alopecia, skin hyperpigmentation, and nail dystrophy. Patients can typically present with diarrhea, weight loss, protein-losing enteropathy, and nutritional deficiency. However, it can demonstrate diverse other clinical features, usually with poor prognosis. Currently, there are no specific diagnostic criteria established yet. The etiology of CCS is still obscure, but an autoimmune process has been suggested. Here we present an 81-year-old Caucasian female who had clinical presentations, physical exam, imaging, endoscopy and pathology findings that were all consistent with the diagnosis of CCS. We also include a detailed literature review of the other gastrointestinal polyposis syndromes (hamartomatous, adenomatous, hyperplastic and inflammatory polyposis). A high index of suspicion and recognition of the characteristic clinical, endoscopic as well as histopathological findings of CCS, as well as different gastrointestinal polyposis conditions, can help clinicians with more timely and correct diagnosis.

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Cap Polyposis: Further Experience and Review

Abstract: Cap polyposis is eminently treatable with good long-term prognosis and function. Patients with solitary cap polyp respond well to endoscopic polypectomy. However, patients with multiple polyps and concurrent anorectal pathology require surgical resection.

Cited by 53 publications

References 18 publications

A Retrospective Study of Inflammatory Colorectal Polyps in Miniature Dachshunds

A Retrospective Study of Inflammatory Colorectal Polyps in Miniature Dachshunds

A Case of Cap Polyposis with Epidermal Nevus in an Infant

Cronkhite-Canada Syndrome: A Case Report and Literature Review of Gastrointestinal Polyposis Syndrome

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