Capillary electrophoresis in clinical toxicology

Stereoselective screening for and confirmation of urinary enantiomers of amphetamine, methamphetamine, designer drugs, methadone and selected metabolites by capillary electrophoresis

“…In our previous investigations, urinary enantiomers of MDMA and two of its metabolites [14,26] as well as urinary enantiomers of MET and its major metabolite EDDP [29] were determined by chiral CE using an acidic KH 2 PO 4 buffer and OHP-b-CD. The same buffer was found to be suitable for the simultaneous separation of the enantiomers of A, MA, MDA, MDMA, MDE, EDDP and MET (in the order of detection; Figs.…”

“…Liquid chromatography [11,12] and capillary electrophoresis (CE) [13,14] with multiwavelength solute detection represent other confirmatory methods. Independent of the method used, the customary assays are typically not enantioselective.…”

Micellar electrokinetic capillary chromatography as a powerful tool for pharmacological investigations without sample pretreatment: A precise technique providing cost advantages and limits of detection to the low nanomolar range

“…In the above-mentioned earlier works, high mmolar levels have been determined with reproducibilities in the range of about 2±5% for repeatability (n & 10) and of about 4± 12% for interday precision, respectively ( [2,26], reviews in [11,30,31]; compare Table 13). Generally, CE suffers from a relatively low concentration sensitivity.…”

Les nouvelles technologies au service de la toxicologie clinique

“…Quelques études en EC présentent des méthodes spéci-fiques pour le screening de plusieurs classes de molé-cules après extraction dans les milieux biologiques (4,(16)(17)(18)(19) …”