Capillin, a major constituent of Artemisia capillaris Thunb. flower essential oil, induces apoptosis through the mitochondrial pathway in human leukemia HL-60 cells

Masuda, Yutaka; Asada, Keisuke; Satoh, Rei; Takada, Kohei; Kitajima, Junichi

doi:10.1016/j.phymed.2015.03.008

Cited by 22 publications

(9 citation statements)

References 32 publications

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“…37,41) A. capillaris has been widely used to treat various hepatic disorders in traditional Oriental medicine. 42,43) Some species are used to stabilize sand in desert or semidesert areas or as herbage for feeding livestock.…”

Section: Discussionmentioning

confidence: 99%

DNA Barcode for Identifying Folium Artemisiae Argyi from Counterfeits

Quanxi

Chen

et al. 2016

Biological & Pharmaceutical Bulletin

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Folium Artemisiae Argyi is an important herb in traditional Chinese medicine. It is commonly used in moxibustion, medicine, etc. However, identifying Artemisia argyi is difficult because this herb exhibits similar morphological characteristics to closely related species and counterfeits. To verify the applicability of DNA barcoding, ITS2 and psbA-trnH were used to identify A. argyi from 15 closely related species and counterfeits. Results indicated that total DNA was easily extracted from all the samples and that both ITS2 and psbA-trnH fragments can be easily amplified. ITS2 was a more ideal barcode than psbA-trnH and ITS2 psbA-trnH to identify A. argyi from closely related species and counterfeits on the basis of sequence character, genetic distance, and tree methods. The sequence length was 225 bp for the 56 ITS2 sequences of A. argyi, and no variable site was detected. For the ITS2 sequences, A. capillaris, A. anomala, A. annua, A. igniaria, A. maximowicziana, A. princeps, Dendranthema vestitum, and D. indicum had single nucleotide polymorphisms (SNPs). The intraspecific Kimura 2-Parameter distance was zero, which is lower than the minimum interspecific distance (0.005). A. argyi, the closely related species, and counterfeits, except for Artemisia maximowicziana and Artemisia sieversiana, were separated into pairs of divergent clusters by using the neighbor joining, maximum parsimony, and maximum likelihood tree methods. Thus, the ITS2 sequence was an ideal barcode to identify A. argyi from closely related species and counterfeits to ensure the safe use of this plant. Key words Folium Artemisiae Argyi; DNA barcoding; ITS2; psbA-trnHFolium Artemisiae Argyi, the dried leaves of Artemisia argyi Levl. et Van, is an important herb in traditional Chinese medicine and is commonly used in moxibustion, medicine, food, or medicinal bath.1-4) A. argyi is widely distributed in Korea, Mongolia, Japan, and the Russia Far East.1,5,6) Folium Artemisiae Argyi was first recorded in "Shi Jing" near 1100 BC and in many clinical and medicine literature, such as "Wu Shi Er Bing Fang," "Ben Cao Gang Mu," and "Jin Gui Yao Lve." 3,7) In traditional Chinese medicine, Folium Artemisiae Argyi was considered to have bitter, pungent, and warm properties and associated with the liver, spleen, and kidney meridians.8) Folium Artemisiae Argyi prevents and cures gynecological, respiratory, and dermatological diseases, such as menstruation-related symptoms, infertility, dysmenorrhea, inflammation, hemostasis, tuberculosis, asthma, and eczema. 9-11)Folium Artemisiae Argyi contains complex ingredients, including essential oil, polysaccharide, flavonoid, tannin, sterols, and triterpenes. [12][13][14][15][16] Unfortunately, identifying A. argyi is difficult because this plant exhibits similar morphological characteristics to closely related species and counterfeits, including congeneric plants Artemisia lavandulifolia, Artemisia anomala, Artemisia princeps, Artemisia indica, Artemisia stolonifera, Dendranthema vestitum, and Dendranthema indicum.1-...

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Section: Discussionmentioning

confidence: 99%

DNA Barcode for Identifying Folium Artemisiae Argyi from Counterfeits

Quanxi

Chen

et al. 2016

Biological & Pharmaceutical Bulletin

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“…flower led to chromatin condensation and nuclear fragmentation. Additionally, the elevation of ERK1/2, JNK and cytochrome c release was observed in Capillin treated HL-60 cells [50]. Carnosic acid, separated from Rosmarinus officinalis polyphenol, induced apoptosis of HL-60 cells by regulating PTEN-Akt signaling pathways.…”

Section: Natural Compounds and Acute Myeloid Leukemiamentioning

confidence: 99%

Natural Products and Acute Myeloid Leukemia: A Review Highlighting Mechanisms of Action

et al. 2019

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Recent findings have shown great potential of alternative interventions such as immunotherapy and natural products for acute myeloid leukemia (AML). This study aims to review the anti-AML effect of various natural compounds. Natural compounds were classified into five groups: alkaloids, carotenoids, nitrogen-containing compounds, organosulfur compounds or phenolics based on each compound’s chemical properties. Fifty-eight studies were collected and reviewed in this article. Phenolics are the most abundant group to have an apoptotic effect over AML cells, while other groups have also shown significant apoptotic effects. Some compounds induced apoptosis by regulating unique mechanism like human telomerase reverse transcriptase (hTERT) or laminin receptor (67LR), while others modified caspases, poly (adp-ribose) polymerase (PARP) and p53. Further study is required to identify side-effects of potent compounds and the synergistic effects of combination of two or more natural compounds or existing conventional anti-AML drugs to treat this dreadful disease.

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“…These results are opposed to the inhibition of TGF- β 1 induced apoptosis [ 52 ], but A. capillaris prevented apoptotic morphological changes of normal hepatocytes, not tumor cells in this study. Moreover, A. capillaris was also found to promote the apoptotic process in cancer cells like the human leukemia HL-60 cells or nasopharyngeal carcinoma cells (CNE-2 cells), even though they are not related to the liver [ 28 , 53 ]. In view of these results, intensive studies are required to expand the possible application of the antitumor effects of A. capillaris to other forms of cancer.…”

Section: Therapeutic Effects Of a Capillarismentioning

confidence: 99%

“…Capillin, the most active and major substance found in A. capillaris , upregulated the apoptotic processes and thereby induced antitumor effects in human leukemia HL-60 cells by splitting DNA and activating the JNK/stress-activated protein kinases (SAPK) pathway. IC 50 value for tumor-suppressive activity of capillin was 6.5 ± 2.9 μ M, which was 7.6- to 30-fold lower than those of capillin (134.9 ± 16.4 μ M), capillarisin (49.3 ± 12.2 μ M), and 6,7-dimethylesculetin (197.4 ± 17.5 μ M), indicating its strong growth-inhibitory activity [ 28 ]. Capillin (1–10 μ M) from Artemisia monosperma also had cytotoxic and proapoptotic effects on four human tumor cells including colon, pancreatic, lung, and larynx carcinomas [ 59 ].…”

Section: Medicinal Effects Of Various Constituents Of Amentioning

confidence: 99%

A Survey of Therapeutic Effects ofArtemisia capillarisin Liver Diseases

Jang

Kim

Lee

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Artemisia capillaris has been recognized as an herb with therapeutic efficacy in liver diseases and widely used as an alternative therapy in Asia. Numerous studies have reported the antisteatotic, antioxidant, anti-inflammatory, choleretic, antiviral, antifibrotic, and antitumor activities of A. capillaris. These reports support its therapeutic potential in various liver diseases such as chronic hepatitis B virus (HBV) infection, cirrhosis, and hepatocellular carcinoma. In addition, several properties of its various constituents, which provide clues to the underlying mechanisms of its therapeutic effects, have been studied. This review describes the scientific evidence supporting the therapeutic potential of A. capillaris and its constituents in various liver diseases.

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Capillin, a major constituent of Artemisia capillaris Thunb. flower essential oil, induces apoptosis through the mitochondrial pathway in human leukemia HL-60 cells

Cited by 22 publications

References 32 publications

DNA Barcode for Identifying Folium Artemisiae Argyi from Counterfeits

DNA Barcode for Identifying Folium Artemisiae Argyi from Counterfeits

Natural Products and Acute Myeloid Leukemia: A Review Highlighting Mechanisms of Action

A Survey of Therapeutic Effects ofArtemisia capillarisin Liver Diseases

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