Capparis zeylanica mediated bio-synthesized ZnO nanoparticles as antimicrobial, photocatalytic and anti-cancer applications

Nilavukkarasi, M.; Vijayakumar, S.; Prathipkumar, S.

doi:10.1016/j.mset.2019.12.004

Cited by 63 publications

(24 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to our present results, previous studies have demonstrated a dose-dependent growth inhibition on E. faecalis using agar diffusion by gelatin-coated ZnO NPs and ZnO NPs, respectively ( Dowlatababdi et al, 2017 ; Divya et al, 2018 ; Sukri et al (2019) confirmed a higher antibacterial potential of green synthesized ZnO NPs on E. faecalis by reporting 22.09 μg/ml of ZnO NPs as the minimum inhibitory concentration inhibiting 50% growth for E. faecalis compared to 64.53 μg/ml for Gram-negative bacterium E. coli . A study by Nilavukkarasi et al (2020) demonstrated a more effective antibacterial action of ZnO NPs on Gram-positive bacterium S. epidermidis than S. paratyphi , which is a Gram-negative bacterium.…”

Section: Resultsmentioning

confidence: 99%

Remedial Aspect of Zinc Oxide Nanoparticles Against Serratia Marcescens and Enterococcus Faecalis

et al. 2022

View full text Add to dashboard Cite

Zinc oxide nanoparticles (ZnO NPs) have been widely used in biomedical applications due to their high biocompatibility and low toxicity to humans. The present work aimed to investigate the antibacterial effects of different concentrations of ZnO NPs on two opportunistic pathogens, Serratia marcescens and Enterococcus faecalis. The surface interaction between nanoparticles and bacterial cell wall, and the subsequent morphological alterations on the bacterial surface, were examined through Fourier transform infrared spectroscopy and scanning electron microscope. The energy dispersive X-ray analysis was used to confirm the elemental composition of ZnO NPs and the cellular accumulation of ZnO NPs in bacteria. The growth-inhibitory test demonstrated a dose-dependent growth inhibitory effect of ZnO NPs against both the test bacteria, as the higher concentration of nanoparticles caused the higher bacterial growth inhibition. The results showed that ZnO NPs caused a higher growth inhibition (63.50 ± 2.50%) on the Gram-positive bacterium E. faecalis compared to the Gram-negative bacterium S. marcescens (51.27 ± 4.56%). Fourier transform infrared spectrum revealed the possible involvement of hydroxyl, carboxyl, amides, methylene, and phosphate groups from the biomolecules of bacterial cell wall such as proteins, carbohydrates, lipids, and phospholipids in the interaction of ZnO NPs on bacterial cell surface. Energy dispersive X-ray analysis showed the higher accumulation of ZnO NPs in E. faecalis than S. marcescens analogous to the bacterial growth inhibition. Scanning electron microscopy images confirmed the antibacterial properties of ZnO NPs, showing the loss of integrity of cell membrane and distortion of bacterial cells. Hence, the potential of ZnO NP as an antibacterial agent against S. marcescens and E. faecalis has been confirmed.

show abstract

Section: Resultsmentioning

confidence: 99%

Remedial Aspect of Zinc Oxide Nanoparticles Against Serratia Marcescens and Enterococcus Faecalis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…This prevents the recombination of electrons (e − ) and holes (h + ), which in turn increases the formation of AOS, making the degradation process of the dye more efficacious. [44,45]. Scheme 1 shows the well-known basic mechanism of photocatalytic activity of ZnO NPs [42].…”

Section: Photocatalytic Degradation Of Dyesmentioning

confidence: 99%

Greener Synthesis of Zinc Oxide Nanoparticles: Characterization and Multifaceted Applications

et al. 2020

View full text Add to dashboard Cite

Nanoparticles (NPs) have unique properties compared to their bulk counterparts, and they have potentials for various applications in many fields of life science. Green-synthesized NPs have garnered considerable interest due to their inherent features such as rapidity, eco-friendliness and cost-effectiveness. Zinc oxide nanoparticles (ZnO NPs) were synthesized using an aqueous extract of Kalanchoe blossfeldiana as a reducing agent. The resulting nanoparticles were characterized via X-ray diffraction (XRD), dynamic light scattering (DLS), UV-Vis spectroscopy, photoluminescence (PL), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS). The antimicrobial potential of the synthesized ZnO NPs against bacterial and fungal strains was examined by the disk diffusion method, and they showed a promising antibacterial and antifungal potential. The catalytic activity of the synthesized ZnO NPs in reducing methylene blue (MB) and eosin was studied via UV-Vis spectroscopy. The decolorization percentages of the MB and Eosin Y dyes were 84% and 94%, respectively, which indicate an efficient degradation of the ZnO NPs. In addition, the cytotoxic activity of the ZnO NPs on the HeLa cell line was evaluated via in vitro assay. The MTT assay results demonstrate a potent cytotoxic effect of the ZnO NPs against the HeLa cancer cell line.

show abstract

“…Finally, the cytotoxicity study revealed the antiproliferative properties of ZnO nanoparticles against A549 cancer cell lines. [23] The toxic effects of nanoparticles on target cells may be attributable to two different actions: (i) chemical toxicity depending on the chemical structure, i. e. the surface chemistry of ZnO nanoparticles readily lends them to functionalization with targeting proteins or chemical groups, and may be a key to rendering them to be cancer targeting; and (ii) The ROS production resulting from oxidative stress are size-dependent, i. e., smaller NPs cause better ROS overproduction. [24,25] ZnO is a well-known multi-functional and direct band gap semiconductor with excellent size-dependent tunable optical properties that are of great interest in nanoparticle-based drug delivery, bio-imagery and biomedical research pharmaceuticals for human use.…”

Section: Introductionmentioning

confidence: 99%

Characterization Study of Cytotoxicity of Green Synthesized ZnO Nanoparticles Loaded with Anti‐Cancer Doxorubicin Drug

2021

View full text Add to dashboard Cite

The green synthesized zinc oxide nanoparticle (ZnO) was filled with a commercially available anti-cancer drug, Doxorubicin (DoX). The loading of the drug into ZnO was validated using UV-Visible and Raman spectroscopy. X-ray diffraction data showed the wurtzite structure of the nanoparticles of ZnO. Scanning electron microphotography images detected the encapsulation of DoX drugs into ZnO nanoparticles. Fourier transformer infrared spectrum of DoX loaded ZnO showed a single band at 478 cm À 1 attributed to the ZnO vibrational band and the carbonyl group peak at 1578 cm À 1 , suggesting the loading of DoX into ZnO. In addition, in vitro cytotoxicity of DoX, ZnO and ZnO-DoX against HeLa cells was studied using the MTT colorimetric cell viability assay, which showed 99.4 % inhibition of ZnO-DoX cells at a concentration of 100 μg/mL. The findings thus provide compelling evidence for green biosynthesized ZnO, which could serve as a promising nanodrug carrier for the targeted drug delivery system.

show abstract

Capparis zeylanica mediated bio-synthesized ZnO nanoparticles as antimicrobial, photocatalytic and anti-cancer applications

Cited by 63 publications

References 22 publications

Remedial Aspect of Zinc Oxide Nanoparticles Against Serratia Marcescens and Enterococcus Faecalis

Remedial Aspect of Zinc Oxide Nanoparticles Against Serratia Marcescens and Enterococcus Faecalis

Greener Synthesis of Zinc Oxide Nanoparticles: Characterization and Multifaceted Applications

Characterization Study of Cytotoxicity of Green Synthesized ZnO Nanoparticles Loaded with Anti‐Cancer Doxorubicin Drug

Contact Info

Product

Resources

About