Capsaicin inhibits benzo(a)pyrene-induced lung carcinogenesis in an in vivo mouse model

Anandakumar, Pandi; Kamaraj, Sattu; Jagan, Sundaram; Ramakrishnan, G.; Asokkumar, Selvamani; Naveenkumar, Chandrashekar; Subramanian, R.; Devaki, Thiruvengadam

doi:10.1007/s00011-012-0511-1

Cited by 69 publications

(36 citation statements)

References 30 publications

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“…The inhibition by capsaicin of microsomal mono-oxygenases involved in carcinogen activation implies its chemopreventive potential. The anti-tumor activity of capsaicin against benzo(α) pyrene-induced lung tumorigenesis has been reported in mice (Anandakumar et al, 2012).…”

Section: Chemopreventive Activity Of Capsaicinmentioning

confidence: 99%

Biological Activities of Red Pepper (Capsicum annuum) and Its Pungent Principle Capsaicin: A Review

Srinivasan

2015

Critical Reviews in Food Science and Nutrition

340

186

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Capsaicin, the pungent alkaloid of red pepper (Capsicum annuum) has been extensively studied for its biological effects which are of pharmacological relevance. These include: cardio protective influence, antilithogenic effect, antiinflammatory, and analgesia, thermogenic influence, and beneficial effects on gastrointestinal system. Therefore, capsaicinoids may have the potential clinical value for pain relief, cancer prevention and weight loss. It has been shown that capsaicinoids are potential agonists of capsaicin receptor (TRPV1). They could exert the effects not only through the receptor-dependent pathway but also through the receptor-independent one. The involvement of neuropeptide Substance P, serotonin, and somatostatin in the pharmacological actions of capsaicin has been extensively investigated. Topical application of capsaicin is proved to alleviate pain in arthritis, postoperative neuralgia, diabetic neuropathy, psoriasis, etc. Toxicological studies on capsaicin administered by different routes are documented. Capsaicin inhibits acid secretion, stimulates alkali and mucus secretion and particularly gastric mucosal blood flow which helps in prevention and healing of gastric ulcers. Antioxidant and antiinflammatory properties of capsaicin are established in a number of studies. Chemopreventive potential of capsaicin is evidenced in cell line studies. The health beneficial hypocholesterolemic influence of capsaicin besides being cardio protective has other implications, viz., prevention of cholesterol gallstones and protection of the structural integrity of erythrocytes under conditions of hypercholesterolemia. Beneficial influences of capsaicin on gastrointestinal system include digestive stimulant action and modulation of intestinal ultrastructure so as to enhance permeability to micronutrients.

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Section: Chemopreventive Activity Of Capsaicinmentioning

confidence: 99%

Biological Activities of Red Pepper (Capsicum annuum) and Its Pungent Principle Capsaicin: A Review

Srinivasan

2015

Critical Reviews in Food Science and Nutrition

340

186

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“…TNF-a is a key proinflammatory cytokine perform a significant function in the lung cancer development induced by B(a)P. 38 Cytokines release from the cell due to stimulation by oxidative stress. 39 In the present study, results give direct evidence that B(a)P treatment significantly increases lungs TNF-a level.…”

mentioning

confidence: 99%

Methanolic bark extract of Acacia catechu ameliorates benzo(a)pyrene induced lung toxicity by abrogation of oxidative stress, inflammation, and apoptosis in mice

Shahid

Rashid

Ali

et al. 2016

Environmental Toxicology

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Benzo(a)pyrene [B(a)P] is a well-known carcinogen present in the environment. In this study, we evaluated the protective potential of methanolic bark extract of Acacia catechu Willd. (MEBA) against the lung toxicity induced by B(a)P in Swiss albino mice. To determine the protective efficacy of MEBA, it was orally administered to the mice at two doses (200 and 400 mg/kg body weight) once daily for 7 days. Mice were also exposed (orally) to B(a)P at a dose of 125 mg/kg body weight on 7th day. Administration of B(a)P increased the activities of toxicity markers such as LDH, LPO, and XO with a subsequent decrease in the activities of tissue anti-oxidant armory (CAT, SOD, GST, GPx, GR, QR, and GSH). It also caused activation of the apoptotic and inflammatory pathway by upregulation of TNF-α, NF-kB, COX-2, p53, bax, caspase-3, and downregulating Bcl-2. Pretreatment with MEBA at two different doses (200 and 400 mg/kg body weight) significantly ameliorates B(a)P-induced increased toxicity markers and activities of detoxifying enzymes along with the levels of glutathione content. It also significantly attenuated expression of apoptotic and inflammatory markers in the lungs. Histological results further confirmed the protective role of MEBA against B(a)P-induced lung toxicity. The results indicate that MEBA may be beneficial in ameliorating the B(a)P-induced oxidative stress, inflammation, and apoptosis in the lungs of mice. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1566-1577, 2017.

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“…Also, there is increasing evidence that TNF-α is mainly produced by cancers and act as an endogenous tumor promoter (49). Studies have shown that B(a)P administration promotes the increase of TNF-α levels in pulmonary tumor bearing mice (50). At 10th week of Aq.Tc and AG treatment to cancer bearing animals significantly downregulated the levels of TNF-α to near normal values.…”

Section: Discussionmentioning

confidence: 99%

Anticancer potential of Tinospora cordifolia and arabinogalactan against benzo(a)pyrene induced pulmonary tumorigenesis: a study in relevance to various biomarkers

Mohan¹,

Koul²

2018

J Herbmed Pharmacol

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Tinospora cordifolia plant and its various bioactive components have wide range of pharmacological properties. Aqueous extract of Tinospora cordifolia stem and arabinogalactan (AG), its bioactive polysaccharide, act as anti-cancer agents and have the potential for preparation of new drugs against lung cancer. Please cite this paper as: Mohan V, Koul A. Anticancer potential of Tinospora cordifolia and arabinogalactan against benzo(a) pyrene induced pulmonary tumorigenesis: a study in relevance to various biomarkers.

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Capsaicin inhibits benzo(a)pyrene-induced lung carcinogenesis in an in vivo mouse model

Abstract: The results of the present study indicate the protective effect of capsaicin against benzo(a)pyrene-induced lung carcinogenesis in mice.

Cited by 69 publications

References 30 publications

Biological Activities of Red Pepper (Capsicum annuum) and Its Pungent Principle Capsaicin: A Review

Biological Activities of Red Pepper (Capsicum annuum) and Its Pungent Principle Capsaicin: A Review

Methanolic bark extract of Acacia catechu ameliorates benzo(a)pyrene induced lung toxicity by abrogation of oxidative stress, inflammation, and apoptosis in mice

Anticancer potential of Tinospora cordifolia and arabinogalactan against benzo(a)pyrene induced pulmonary tumorigenesis: a study in relevance to various biomarkers

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