Carbapenemase and virulence factors of Enterobacteriaceae in North Lebanon between 2008 and 2012: evolution via endemic spread of OXA-48

Abstract

Horizontal transfer of related plasmids has facilitated the spread of the bla(OXA-48) gene into several Enterobacteriaceae species, including virulent E. coli. Their clonal diversity and the presence of faecal carriers in the community suggest an endemic spread of OXA-48.

Carriage of carbapenemase‐ and extended‐spectrum cephalosporinase‐producing Escherichia coli and Klebsiella pneumoniae in humans and livestock in rural Cambodia; gender and age differences and detection of blaOXA‐48 in humans

“…pneumoniae in rural Cambodia in 2011 was still low, 1% in humans and not detected in livestock. Community carriage of bla OXA‐48 harbouring Enterobacteriaceae is rare, but has been reported from humans in Lebanon (Beyrouthy et al, ) and Switzerland (Zurfluh et al, ). Bla OXA‐48 harbouring isolates expressed a non‐wild‐type phenotype to meropenem, ciprofloxacin, sulfamethoxazole/trimethoprim, piperacillin/tazobactam, tetracycline and chloramphenicol but colistin resistance genes were not detected.…”

Detection of Escherichia coli O157:H7 and O104:H4 in patients with diarrhea in Northern Lebanon and characterization of fecal E.coli producing ESBL and carbapenemase genes

“…A Jordanian study reported recently that MDR E.coli isolates from feces of infants accounted for 30.6%, and all were ESBL producers. [32]. In China, the prevalence of carbapenems-resistant among Enterobacteriaceae in the fecal flora of hospitalized patients was 6.6% (20/303 patients), of which 8 isolates were carried bla KPC-2 , bla IMP-4 and bla NDM-1 and typed as carbapenemase producers [33].…”

Prolonged Carriage and Potential Onward Transmission of Carbapenemase-Producing Enterobacteriaceae in Dutch Travelers

“…and [38][39][40][41]. More recently, the OXA-48-like variant OXA-244 was also identified in an ST38 E. coli isolated from a hospitalized patient in France without any travel history [42].…”