Carbohydrate antigens as potential biomarkers for the malignancy in patients with idiopathic deep venous thrombosis: A retrospective cohort study

Yu, Miao; Wang, Yunlong; Abdalla, Ahmed M; Liu, Wenqi; Mei, Fei; Wang, Jian; Ouyang, Chenxi; Li, Yiqing

doi:10.1007/s11596-014-1342-9

Cited by 3 publications

(4 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serum AFP has been used as a useful marker for recurrent hepatocellular carcinomas even before the clinical symptoms develop. High concentrations of serum AFP were reported in malignant tumours of the gastrointestinal tract, pancreas, lung, and kidney (41). In our study, CA 125, CA 19-9, CA 15-3, and AFP-3 concentrations were higher in sheep with OPA than in the control group and this increase was statistically significant.…”

Section: Discussionsupporting

confidence: 57%

“…CA 125 has been used as a tumour indicator for monitoring cancer patients and evaluating recurrence rates, especially for ovarian cancers. High serum CA 125 concentrations were reported in patients with ovarian cancers as well as in patients with liver disorders (3,41). In addition, CA 125 has been commonly used in diagnosis of malignant gynaecological pelvic tumours.…”

Section: Discussionmentioning

confidence: 99%

“…CA 19-9 is an antigen associated with gastrointestinal cancer types that increases in patients with gastrointestinal carcinomas, particularly where the pancreas is affected (41). CA 19-9 is stated to be a useful biomarker for diagnosing gastrointestinal tract tumours, especially pancreatic and colorectal cancer, adenocarcinomas of ovarian pulpa and serous and mucous adenocarcinomas of the ovarium (7).…”

Section: Discussionmentioning

confidence: 99%

“…CA 15-3 is another tumour biomarker with a large cellular surface mucin glycoprotein that is secreted from several glandular and ductal epithelial cells as well as certain haematopoietic cells (41). Serum AFP has been used as a useful marker for recurrent hepatocellular carcinomas even before the clinical symptoms develop.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Selected tumour biomarker levels in sheep with pulmonary adenomatosis

Özkan

Yıldırım

Huyut

et al. 2020

Journal of Veterinary Research

View full text Add to dashboard Cite

IntroductionSheep pulmonary adenomatosis (ovine pulmonary adenomatosis, OPA, Jaagsiekte) is a chronic contagious bronchoalveolar carcinoma caused by the Jaagsiekte sheep retrovirus. Since effective treatment and a vaccination procedure are not currently possible, control and eradication of the disease is difficult. It leads to serious economic losses around the world, therefore studies are currently underway in order to design control and eradication programmes. In this study, levels and changes in selected tumour markers (carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 125, CA 19-9, CA 15-3, and alphafetoprotein (AFP)-3) and their diagnostic significance were investigated.Material and MethodsA total of 30 sheep were used. Clinical examinations were performed and blood samples were obtained before slaughter from all animals with presumed OPA. Blood samples with positive OPA results by macroscopic and histopathological examination were included in the study as the experimental group and numbered 20. Sheep totalling 10 had negative OPA results and provided control samples.ResultsCEA levels were similar in both groups, and the differences were statistically insignificant (P > 0.05). CA 125, CA 19-9, CA 15-3, and AFP-3 levels were higher in the OPA group than the control group and with statistical significance (P < 0.05). In all OPA animals, CA 125 levels were higher than 1 U/mL.Conclusionserum CAs and AFP levels increase significantly in adenomatous sheep. These tumour markers are thought to facilitate the diagnosis of OPA.

show abstract

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Selected tumour biomarker levels in sheep with pulmonary adenomatosis

Özkan

Yıldırım

Huyut

et al. 2020

Journal of Veterinary Research

View full text Add to dashboard Cite

show abstract

Derivation and validation of a nomogram model for pulmonary thromboembolism in patients undergoing lung cancer surgery

Li¹,

Shen²,

Ding³

et al. 2021

Transl Lung Cancer Res

View full text Add to dashboard Cite

Background: A specific risk-stratification tool is needed to facilitate safe and cost-effective approaches to the prophylaxis of acute pulmonary thromboembolism (PTE) in lung cancer surgery patients. This study aimed to develop and validate a simple nomogram model for the prediction of PTE after lung cancer surgery using readily obtainable clinical characteristics. Methods: A total of 14,427 consecutive adult patients who underwent lung cancer surgery between January 2015 and July 2018 in our institution were retrospectively reviewed. Included in the cohort were 136 patients who developed PTE and 544 non-PTE patients. The patients were randomly divided into the derivation group (70%, 95 PTE patients and 380 non-PTE patients) and the validation group (30%, 41 PTE patients and 164 non-PTE patients). A nomogram model was developed based on the results of multivariate logistic analysis in the derivation group. The cut-off values were defined using Youden's index. The prognostic accuracy was measured by area under the curve (AUC) values. Results: In the derivation group, multivariate logistic analysis was carried out to evaluate the risk score. The risk assessment model contained five variables: age [95% confidence interval (CI): 1.008-1.083, P=0.016], body mass index (95% CI: 1.077-1.319, P=0.001), operation time (95% CI: 1.002-1.014, P=0.008), the serum level of cancer antigen 15-3 (CA15-3) before surgery (95% CI: 1.019-1.111, P=0.005), and the abnormal results of compression venous ultrasonography before surgery (95% CI: 2.819-18.838, P<0.001). All of them were independent risk factors of PTE. To simplify the risk assessment model, a nomogram model was established, which showed a good predictive performance in the derivation group (AUC 0.792, 95% CI: 0.734-0.853) and in the validation group (AUC 0.813, 95% CI: 0.737-0.890). Conclusions: A high-performance nomogram was established on the risk factors for PTE in patients undergoing lung cancer surgery. The nomogram could be used to provide an individual risk assessment and guide prophylaxis decisions for patients. Further external validation of the model is needed in lung cancer surgery patients in other clinical centers.

show abstract

Epidemiology of Cancer-Associated Thrombosis in Asia: A Systematic Review

Lee

Nagarajan

Tan

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

The epidemiology of cancer associated thrombosis (CAT) in Asia is less well-studied and differs from that in the western countries. Here, we systematically examine population based and hospital-based studies reported between 1995 and 2020 to understand the epidemiology of CAT in Asia. From population-based studies, the estimated incidence of VTE in cancer patients was 1.85–9.88 per 1,000 person-years. The incidence of CAT in Asia is significantly higher than non-cancer associated VTE in the general population and cancer is perhaps the most important risk factor for VTE. Hospital-based studies were heterogeneous in study designs and reveal a wide range of prevalence of VTE among cancer patients at 0.5–44.6% while the cancer prevalence rates among VTE patients ranged from 6.1 to 65.5%. The cancer sites most associated with VTE and risk factors were similar between Asian and Western studies. CAT has a major impact on the survival of patients with cancer in Asia, but thromboprophylaxis is not commonly practiced and validated risk assessment tools are lacking. This study highlights the urgent need for large multinational epidemiological studies in Asia to establish the true burden of CAT and to guide appropriate prevention strategies.

show abstract

Carbohydrate antigens as potential biomarkers for the malignancy in patients with idiopathic deep venous thrombosis: A retrospective cohort study

Cited by 3 publications

References 38 publications

Selected tumour biomarker levels in sheep with pulmonary adenomatosis

Selected tumour biomarker levels in sheep with pulmonary adenomatosis

Derivation and validation of a nomogram model for pulmonary thromboembolism in patients undergoing lung cancer surgery

Epidemiology of Cancer-Associated Thrombosis in Asia: A Systematic Review

Contact Info

Product

Resources

About