Carbohydrate polymer-based nanocomposites for breast cancer treatment

Moghaddam, Farnaz Dabbagh; Heidari, Golnaz; Zare, Ehsan Nazarzadeh; Djatoubai, Essossimna; Paiva‐Santos, Ana Cláudia; Bertani, Francesca Romana; Wu, Ai-Min

doi:10.1016/j.carbpol.2022.120510

Cited by 29 publications

(6 citation statements)

References 225 publications

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“…188 Fabrication of different carbohydrate polymers into nanosystems can be achieved via the in situ copolymerization technique, solvent casting method or by the electrospinning technique. 189 Glyco-AuNPs can be synthesized through a one, two or three step reaction (Fig. 15).…”

Section: Engineering Aunps With Saccharidesmentioning

confidence: 99%

Tackling breast cancer with gold nanoparticles: twinning synthesis and particle engineering with efficacy

Mal,

Chakraborty,

Mahapatra

et al. 2024

Nanoscale Adv.

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Section: Engineering Aunps With Saccharidesmentioning

confidence: 99%

Tackling breast cancer with gold nanoparticles: twinning synthesis and particle engineering with efficacy

Mal,

Chakraborty,

Mahapatra

et al. 2024

Nanoscale Adv.

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“…1 They are essential for many biological processes, e.g., for cell−cell recognition or the interaction of cells with other species, as well as for the folding and stability of proteins. 2,3 Due to their relevance in many biological processes, glycans and glycoconjugates find industrial applications in many fields: They are used in biomedical applications, for the development of drugs 2,4 or vaccines; 5,6 in nutrition, for the production of human milk oligosaccharides 7,8 or prebiotics; 9,10 and in cosmetics. 11,12 For the chemical synthesis of glycans, several steps of selective protection and deprotection are required due to the numerous glycoside hydroxyl groups found in saccharide structures.…”

Section: Introductionmentioning

confidence: 99%

“…They are the most abundant biopolymers on Earth . They are essential for many biological processes, e.g., for cell–cell recognition or the interaction of cells with other species, as well as for the folding and stability of proteins. , Due to their relevance in many biological processes, glycans and glycoconjugates find industrial applications in many fields: They are used in biomedical applications, for the development of drugs , or vaccines; , in nutrition, for the production of human milk oligosaccharides , or prebiotics; , and in cosmetics. , …”

Section: Introductionmentioning

confidence: 99%

Microgels with Immobilized Glycosyltransferases for Enzymatic Glycan Synthesis

Sommerfeld,

Palm,

Hussnaetter

et al. 2024

Biomacromolecules

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Glycans, composed of linked monosaccharides, play crucial roles in biology and find diverse applications. Enhancing their enzymatic synthesis can be achieved by immobilizing enzymes on materials such as microgels. Here, we present microgels with immobilized glycosyltransferases, synthesized through droplet microfluidics, immobilizing enzymes either via encapsulation or postattachment. SpyTag-SpyCatcher interaction was used for enzyme binding, among others. Fluorescamine and permeability assays confirmed enzyme immobilization and microgel porosity, while enzymatic activities were determined using HPLC. The potential application of microgels in cascade reactions involving multiple enzymes was demonstrated by combining β4GalT and α3GalT in an enzymatic reaction with high yields. Moreover, a cascade of β4GalT and β3GlcNAcT was successfully implemented. These results pave the way toward a modular membrane bioreactor for automated glycan synthesis containing the presented biocatalytic microgels.

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“…Although it is not common, men also may suffer from breast cancer and the most reported types are ILC and IDC. Every type of these breast tumors needs special prognosis and treatment, which vastly depend on cancer stage, grade, expression of receptors, age and sex of the patient, and overall health. − …”

Section: Introductionmentioning

confidence: 99%

Bioengineered Smart Nanocarriers for Breast Cancer Treatment: Adorned Carbon-Based Nanocomposites with Silver and Palladium Complexes for Efficient Drug Delivery

Safarkhani,

Moghaddam,

Taghavimandi

et al. 2023

ACS Omega

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Biocompatible and bioactive carbon-based nanocomposites are ingeniously designed and fabricated with the aim of enhancing drug delivery applicability in breast cancer treatment. Reduced graphene oxide (rGO) and multiwalled carbon nanotubes (MWCNTs) are utilized as nanocarriers for increasing penetrability into cells and the loading capacity. What sets our study apart is the strategic incorporation of the two different complexes of silver (AgL2) and palladium (PdL2) with the carboxamide-based ligand C9H7N3OS (L), which have been synthesized and decorated on nanocarriers alongside doxorubicin (DOX) for stabilizing DOX by π–π interactions and hydrogen bonding. Although DOX is a well-known cancer therapy agent, the efficacy of DOX is hindered owing to drug resistance, poor internalization, and limited site specificity. Aside from stabilizing DOX on nanocarriers, our carbon-based nanocarriers are tailored to act as a precision-guided missile, strategically by adorning with target-sensitive complexes. Based on the literature, carboxamide ligands can connect to overexpressed receptors on cancerous cells and inhibit them from proliferation signaling. Also, the complexes have an antibacterial activity that can control the infection caused by decreasing white blood cells and necrosis of cancerous cells. A high-concentration cytotoxicity assay revealed that decorating PdL2 on a DOX-containing nanocarrier not only increased cytotoxicity to breast cancerous cell lines (MDA-MB-231 and MCF-7) but also revealed higher cell viability on a normal cell line (MCF-10A). The drug release screening results showed that the presence of PdL2 led to 72 h correlate release behavior in acidic and physiological pH profiles, while the AgL2‑containing nanocomposite showed an analogue behavior for just 6 h and the release of DOX continued and after about 100 h hit the top.

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Carbohydrate polymer-based nanocomposites for breast cancer treatment

Cited by 29 publications

References 225 publications

Tackling breast cancer with gold nanoparticles: twinning synthesis and particle engineering with efficacy

Tackling breast cancer with gold nanoparticles: twinning synthesis and particle engineering with efficacy

Microgels with Immobilized Glycosyltransferases for Enzymatic Glycan Synthesis

Bioengineered Smart Nanocarriers for Breast Cancer Treatment: Adorned Carbon-Based Nanocomposites with Silver and Palladium Complexes for Efficient Drug Delivery

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