Carbon-Based Nanomaterials for Targeted Drug and Gene Delivery Systems

Makwikwi, Tendai; Kumar, Govindarajan Venkat; Manicum, Amanda-Lee E.; Sekaran, Saravanan; Katerere, David R.

doi:10.1007/978-3-031-12658-1_16

Cited by 3 publications

(1 citation statement)

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“…Their unique and inherent properties such as superior hardness and Young’s modulus, optical properties and fluorescence, resistance to harsh environments, high thermal conductivity, and electrical resistivity have attracted remarkable scientific attention for various applications [ 279 ]. NDs are also intrinsically biocompatible with low toxicity, stable fluorescence, high thermal conductivity, and large surface areas, which makes them suitable for biomedical applications such as drug/gene delivery [ 280 ], bio-imaging, and biosensors [ 281 ]. As delivery systems, NDs are capable of transferring a broad range of therapeutic materials such as proteins, small molecule inhibitors, peptides, and chemotherapy drugs.…”

Section: Carbon-based Nanostructuresmentioning

confidence: 99%

Carbon-Based Nanostructures as Emerging Materials for Gene Delivery Applications

Yazdani,

Mozaffarian,

Pazuki

et al. 2024

Pharmaceutics

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Gene therapeutics are promising for treating diseases at the genetic level, with some already validated for clinical use. Recently, nanostructures have emerged for the targeted delivery of genetic material. Nanomaterials, exhibiting advantageous properties such as a high surface-to-volume ratio, biocompatibility, facile functionalization, substantial loading capacity, and tunable physicochemical characteristics, are recognized as non-viral vectors in gene therapy applications. Despite progress, current non-viral vectors exhibit notably low gene delivery efficiency. Progress in nanotechnology is essential to overcome extracellular and intracellular barriers in gene delivery. Specific nanostructures such as carbon nanotubes (CNTs), carbon quantum dots (CQDs), nanodiamonds (NDs), and similar carbon-based structures can accommodate diverse genetic materials such as plasmid DNA (pDNA), messenger RNA (mRNA), small interference RNA (siRNA), micro RNA (miRNA), and antisense oligonucleotides (AONs). To address challenges such as high toxicity and low transfection efficiency, advancements in the features of carbon-based nanostructures (CBNs) are imperative. This overview delves into three types of CBNs employed as vectors in drug/gene delivery systems, encompassing their synthesis methods, properties, and biomedical applications. Ultimately, we present insights into the opportunities and challenges within the captivating realm of gene delivery using CBNs.

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Section: Carbon-based Nanostructuresmentioning

confidence: 99%