Carbon coated magnetic nanoparticles for local drug delivery using magnetic implants

Abstract

Bioferrofluids obtained from carbon coated iron nanoparticles are promising candidates for magnetic drug delivery. The carbon cages render the particles biocompatible, and provide a good support for drug adsorption. We propose a method in which gold plated permanent magnets are implanted directly in the affected organ, close to the tumour, by endoscopic techniques. The bioferrofluid charged with the chemotherapeutic agent is injected and the particles attracted to the magnet, then desorption of the drug takes place at the tumoral region. This method seems to be more promising, costless and effective than that based on the application of external magnetic fields. Preliminary results of drug adsorption and a preclinical experimental animal model are described.

Synthesis and Characterization of Magnetic Metal-encapsulated Multi-walled Carbon Nanobeads

“…The saturation magnetization for Ni-encapsulated MWNB was 15 emu/g, whereas for Ni-encapsulated MWNT it was 22 emu/g due to the discontinuous capillary filling of Ni during the growth process. The saturation magnetization values of metal-encapsulated MWNB and MWNT obtained by the present single-step CVD method using alloy hydride catalyst are comparable with those of the carbon-coated nanoparticles [28] and metal-filled CNTs [6,7] obtained from the three-step process. The applications of these materials for energy and biological aspects are in progress.…”

Uniform Carbon-Coated ZnO Nanorods: Microwave-Assisted Preparation, Cytotoxicity, and Photocatalytic Activity

“…Instead, at particle concentrations of 100, 10, and 5 μg/mL, they were found to promote the growth of the cells. The reduced cytotoxicity in carbon-coated ZnO NRs was understandable because the carbon layer on the surface of ZnO NRs not only increases the biocompatibility of ZnO NRs but also slows the dissolution of ZnO in the culture medium. , However, we are not clear as to why low concentrations of carbon-coated ZnO NRs can promote the growth of the cells. Further investigations will be required to clarify it.…”

Nanoparticle penetration and transport in living pumpkin plants: in situsubcellular identification

“…Carbon-coated iron nanoparticles were produced by the discharge arc method [ 14 , 15 ] based on that previously designed by Krätschmer-Huffman [ 16 ]. The Krätschmer-Huffman method uses a cylindrical chamber, in which there are two graphite electrodes: a stationary anode containing 10 μm starting iron powders, and a moveable graphite cathode.…”