Carbon fiber reinforced polymers for implantable medical devices

Chua, Corrine Ying Xuan; Liu, Hsuan-Chen; Trani, Nicola Di; Susnjar, Antonia; Ho, Jeremy; Scorrano, Giovanni; Rhudy, Jessica; Sizovs, Antons; Lolli, G.; Hernandez, Nathanael; Nucci, M. C.; Cicalo, Roberto; Ferrari, Mauro; Grattoni, Alessandro

doi:10.1016/j.biomaterials.2021.120719

Cited by 62 publications

(24 citation statements)

References 53 publications

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“…For these reasons, efforts have already been made to either adapt the mechanical properties of the metallic implants to those of the bone by investigating other alloys [ 12 , 13 , 14 ] or, for example, by foaming the material [ 15 ]. Efforts are also underway to replace the metallic materials entirely with other materials, such as polymeric composites [ 16 ] or carbon-fiber-reinforced composites [ 17 , 18 ]. Thus, the search for biodegradable material has the greatest relevance, so that a second surgical intervention can be avoided and the material will degrade in the body after a certain time [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of 3D Printing Parameters on the Mechanical Stability of PCL Scaffolds and the Proliferation Behavior of Bone Cells

et al. 2022

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Introduction The use of scaffolds in tissue engineering is becoming increasingly important as solutions need to be found for the problem of preserving human tissue, such as bone or cartilage. In this work, scaffolds were printed from the biomaterial known as polycaprolactone (PCL) on a 3D Bioplotter. Both the external and internal geometry were varied to investigate their influence on mechanical stability and biocompatibility. Materials and Methods: An Envisiontec 3D Bioplotter was used to fabricate the scaffolds. First, square scaffolds were printed with variations in the strand width and strand spacing. Then, the filling structure was varied: either lines, waves, and honeycombs were used. This was followed by variation in the outer shape, produced as either a square, hexagon, octagon, or circle. Finally, the internal and external geometry was varied. To improve interaction with the cells, the printed PCL scaffolds were coated with type-I collagen. MG-63 cells were then cultured on the scaffolds and various tests were performed to investigate the biocompatibility of the scaffolds. Results: With increasing strand thickness and strand spacing, the compressive strengths decreased from 86.18 + 2.34 MPa (200 µm) to 46.38 + 0.52 MPa (600 µm). The circle was the outer shape with the highest compressive strength of 76.07 + 1.49 MPa, compared to the octagon, which had the lowest value of 52.96 ± 0.98 MPa. Varying the external shape (toward roundness) geometry, as well as the filling configuration, resulted in the highest values of compressive strength for the round specimens with honeycomb filling, which had a value of 91.4 + 1.4 MPa. In the biocompatibility tests, the round specimens with honeycomb filling also showed the highest cell count per mm², with 1591 ± 239 live cells/mm2 after 10 days and the highest value in cell proliferation, but with minimal cytotoxic effects (9.19 ± 2.47% after 3 days).

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Section: Introductionmentioning

confidence: 99%

Influence of 3D Printing Parameters on the Mechanical Stability of PCL Scaffolds and the Proliferation Behavior of Bone Cells

et al. 2022

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“…Metals and ceramics have the advantages of excellent corrosion resistance and mechanical properties, 27 but they also suffer from the obviously mechanical disparities between host organs and implant materials 28 . However, polymers are ideal implant materials benefit from the light weight and high strength‐to‐weight ratio 29 . Therefore, in this work, polyurethane (PU) was chosen as a model material for surface modification.…”

Section: Introductionmentioning

confidence: 99%

Construction of antifouling and antibacterial polyhexamethylguanidine/chondroitin sulfate coating on polyurethane surface based on polydopamine rapid deposition

Zhu

Yuan

Zhang

et al. 2022

J of Applied Polymer Sci

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Implanted medical devices are widely used in clinic for disease treatment, but they generally suffer from the bio‐fouling problem which leads to the reduction of service life and loss of therapeutic effects. Herein, an eco‐friendly method based on polydopamine (PDA) fast deposition is developed to construct anti‐fouling and antibacterial surface on polyurethane (PU). The self‐adhesive layer of PDA contributes to the formation of a platform with active sites for further antibacterial and hydrophilic modification. Polyhexamethylguanidine (PHMG) as antibacterial ingredient and chondroitin sulfate (CS) as hydrophilic component covalently bind on PDA platform, which successively helps to form PU‐PDA/PHMG/CS. The resultant surface demonstrates the excellent property of anti‐protein adsorption (96.8%), anti‐bacterial ability (99.9%), and cell compatibility (95.0%), which would have great potential for medical application.

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“…As high-performance structural materials, CFRP not only has the characteristics of typical carbon materials, such as high-temperature resistance, friction resistance, and corrosion resistance, but also has the characteristics of high specific strength, high specific modulus, and high fatigue resistance. Therefore, it has been well applied in different fields such as aerospace [4][5][6], military industry [7], automobile and sports [8,9], and medical treatment [10].…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic Testing of Carbon Fiber-Reinforced Polymer Composites

Wang

Kang

et al. 2022

Journal of Sensors

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Composite materials have been extensively used in different fields due to their excellent properties, among which carbon fiber-reinforced polymer (CFRP) is the representative. Especially in high-precision fields, such as aerospace, CFRP has become the main structural material for some core components instead of metal. The particularity of such materials and their components in terms of structure, material properties, and required detection conditions puts forward more stringent and targeted detection requirements for detection technology. Ultrasonic testing technology as one of the important means of composite defect detection, which is derived from advanced nondestructive testing (NDT), has also been a rapid development. The propagation behavior and variation of ultrasonic waves in CFRP composites can reveal defects and damages in CFRP composites. Moreover, by constructing reasonable defect identification technology and detection technology, not only the qualitative and quantitative positioning analysis of defects and damages in CFRP composites can be realized but also the automatic, visual and intelligent NDT, and evaluation of CFRP composites can be realized. This paper mainly reviews the innovative nondestructive ultrasonic testing technology for CFRP composites and briefly introduces the research progress and application of this technology in CFRP defect detection. Finally, advanced nondestructive ultrasonic testing technology is summarized, and the problems and development direction of this kind of testing technology are put forward.

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Carbon fiber reinforced polymers for implantable medical devices

Cited by 62 publications

References 53 publications

Influence of 3D Printing Parameters on the Mechanical Stability of PCL Scaffolds and the Proliferation Behavior of Bone Cells

Influence of 3D Printing Parameters on the Mechanical Stability of PCL Scaffolds and the Proliferation Behavior of Bone Cells

Construction of antifouling and antibacterial polyhexamethylguanidine/chondroitin sulfate coating on polyurethane surface based on polydopamine rapid deposition

Ultrasonic Testing of Carbon Fiber-Reinforced Polymer Composites

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