“…Biocatalysts such as microorganisms or enzymes with high selectivity and catalytic efficiency have been extensively investigated for the construction of biofuel cells. Among them, laccase (Lac) as a well known multicopper oxidase, which can reduce oxygen into water in a fourelectron transfer step without intermediate formation of hydrogen peroxide, has been widely applied for the reduction of oxygen at the cathode of the enzyme-based biofuel cells [20][21][22][23][24][25][26][27][28][29]. Recently, enzyme-based biofuel cells have attracted considerable research attention because of their unique advantages such as corrosion-free electrolyte, low cost, good biocompatibility and more moderate temperature [29].…”