Carbon nanotubes: A review of novel strategies for cancer diagnosis and treatment

Sheikhpour, Mojgan; Golbabaie, A.; Kasaeian, Alibakhsh

doi:10.1016/j.msec.2017.02.132

Cited by 80 publications

(34 citation statements)

References 88 publications

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“…Today, according to the new approaches in the field of biomimetics in drug delivery and treatment, these natural metabolites can be used with excellent efficiency, but without noticeable side effects [29,30]. Also, they can be used in the design and manufacture of new anticancer nano-bio hybrid drugs [31]. It was demonstrated that ectoine and hydroxyectoine, dose-dependently reduced the viability of QU-DB cell line, the human lung cancer cell.…”

Section: Discussionmentioning

confidence: 99%

Anticancer and Apoptotic Effects of Ectoine and Hydroxyectoine on Non-Small Cell Lung Cancer cells: An in-vitro Investigation

Shaikhpour

2019

Multidiscip Cancer Investig

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Introduction: Streptomyces manage the osmotic stress by collecting compatible solutes or osmolytes. Ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid, and 5-hydroxyectoine are among the most common osmolytes of this bacteria and have an active role in protecting the genetic material of this microorganism as well as providing resistance to environmental pressures. In this research, the antiproliferative and apoptotic effects of ectoine and 5hydroxyectoine on human non-small cell lung cancer (NSCLC) cell line (QU-DB) are investigated. Methods: QU-DB cells were treated by five doses of ectoine and hydroxyectoine for 12, 24 and 48 hours, and the cytotoxic properties were evaluated by MTT assay. Then, the DAPI fluorescent staining was carried out for monitoring of the cells' nuclear morphology. Recognition and quantification of the apoptosis were done; using the Annexin-V-Fluos technique. Results: It has been verified that both ectoine and hydroxyectoine persuaded apoptosis on QU-DB cells in a dose-dependently manner. Also, no cytotoxicity effects of these compatible solutes were observed on normal cells (HFLF-PI5). Conclusions: Ectoine and hydroxyectoine are two natural metabolites which induce apoptosis in lung cancer cells. They don't have any toxic effect on normal cells and can be used as auxiliary drugs or even as a medicine for the treatment of lung cancer after further optimization of the formulations.

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Section: Discussionmentioning

confidence: 99%

Anticancer and Apoptotic Effects of Ectoine and Hydroxyectoine on Non-Small Cell Lung Cancer cells: An in-vitro Investigation

Shaikhpour

2019

Multidiscip Cancer Investig

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“…[83,84] CNTs have also found applications in the biomedical field for cancer diagnosis and treatment. [85] Carbon nanotubes may be envisioned as tube-shaped materials of nanometer dimensions. [86] CNTs are simply classified depending on the number of their layers: single-walled CNTs (SWCNTs), double-walled CNTs (DWCNTs), and multi-walled CNTs (MWCNTs).…”

Section: Polybenzoxazine/carbon Nanotube Compositesmentioning

confidence: 99%

“…Carbon nanotubes (CNTs) display the form of carbon molecules arranged as a cylindrical tube and exhibit remarkable properties which recommend them for countless applications, especially in fields such as microelectronics, energy storage, water treatment, and catalysts . CNTs have also found applications in the biomedical field for cancer diagnosis and treatment …”

Section: Polybenzoxazine/carbon Materials Compositesmentioning

confidence: 99%

Developing Polybenzoxazine Composites Based on Various Carbon Structures

Bîru

Gârea

Iovu

2019

Macro Chemistry & Physics

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The synthesis of composite materials based on various carbon structures and polybenzoxazines (PBZs) gives products with noticeable thermal, electrical, and mechanical properties. The role of different carbon materials is emphasized in terms of the main advantages in both structure and properties. On the other hand, the PBZ features are significant considering the high glass transition temperatures, low flammability, high char yields, and good thermal stability. This review article describes the synthesis, structure, and properties of polybenzoxazine composites based on carbon fibers, carbon nanotubes, graphene, graphene oxide, and other carbonaceous materials. Particular attention is given to the interactions possible to occur between the polybenzoxazine matrix and carbon component.

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“…Size, type, the chemistry of functionalization, charge and hydrophobic nature of nanotubes plays a major role in cellular uptake. [104] The f-CNTs having lengths around 100 nm are able to fit in Clathrin and caveolae vehicle, while CNTs with lengths more than 500 nm may probably be uptaken by the macropinocytosis process. Well, individualised MWCNTs with length around 300 to 400 nm can be easily cross the cell membrane and rapidly entered into the cells and freely traffic in cytoplasm within hr of post internalisation.…”

Section: Drug Loading Mechanism and Cellular Uptake Of Cnt'smentioning

confidence: 99%

The Role of Carbon Nanotubes in Nanobiomedicines

Gulbake

Jain

Gulbake

2017

Int J Pharm Pharm Sci

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CNTs is a fullerene molecule, described in 1991 by the Japanese Scientist ‘‘Sumio Iijima’’ as tube-shaped of graphitic carbon, can be obtained either single or multi-walled nanotube, having a diameter measuring on the nanometer scale, and generally known as buckytubes. Carbon nanotubes (CNTs) have established much recent interest as new entities for experimental disease diagnosis and treatment because of their unique electronic, mechanical, thermal, spectroscopic, metallic, semiconducting and superconducting electron transport properties. Carbon nanotubes can be acquired in numerous ways, the general techniques are Arc discharge, Laser ablation, and Chemical vapour deposition (CVD). Carbon nanotubes are discussed in this review in terms of characters, history, structures, properties, synthesis, purification, characterization methods, toxicity and applications. Purification of nanotubes includes many techniques: Acid treatment, oxidation, annealing, ultrasonication, cutting, magnetic purification, chromatography techniques. Further functionalization enhanced the water solubility of CNT's and completely transformed their biocompatibility profile. Carbon nanotubes, due to their large surface areas, unique surface properties, and needle-like shape, can deliver a lot of therapeutic agents, including DNA, siRNAs and proteins to the target disease sites. CNTs can be readily excreted through the renal route by means of degradation through myeloperoxidase (MOP) enzyme. As CNTs have attracted the fancy of many scientists worldwide, the work beyond our expectations and their simple mechanism with long lasting life makes it more reliable to use. The unique and unusual properties of these structures make them a unique material with a whole range of promising applications.

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Carbon nanotubes: A review of novel strategies for cancer diagnosis and treatment

Cited by 80 publications

References 88 publications

Anticancer and Apoptotic Effects of Ectoine and Hydroxyectoine on Non-Small Cell Lung Cancer cells: An in-vitro Investigation

Anticancer and Apoptotic Effects of Ectoine and Hydroxyectoine on Non-Small Cell Lung Cancer cells: An in-vitro Investigation

Developing Polybenzoxazine Composites Based on Various Carbon Structures

The Role of Carbon Nanotubes in Nanobiomedicines

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